scutellarin Methylester

Effect Mechanism of action

Product Name: scutellarin Methylester
CAS No.: 119262-68-9
Chemical Name: scutellarin Methylester
Synonyms: Scutellarin Methlester;scutellarin Methylester;Breviscapine methyl ester;Scutellarin methyl ester, 10 mM in DMSO;β-D-Glucopyranosiduronic acid, 5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl, methyl ester;5,6-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl beta-D-glucopyranosiduronic acid methyl ester;(2S,3S,4S,5R,6S)-Methyl 6-((5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylate
CBNumber: CB12672945
Molecular Formula: C22H20O12
Formula Weight: 476.39
MOL File: 119262-68-9.mol

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scutellarin Methylester Property

Boiling point:: 804.0±65.0 °C(Predicted)
Density: 1.697±0.06 g/cm3(Predicted)
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: powder
pka: 5.92±0.40(Predicted)
color: Yellow
InChIKey: LNIVUWPCHRNJLG-BPZKQFRZNA-N
SMILES: O(C1=C(O)C(O)=C2C(=C1)OC(C1=CC=C(O)C=C1)=CC2=O)[C@@H]1O[C@H](C(OC)=O)[C@@H](O)[C@H](O)[C@H]1O |&1:21,23,28,30,32,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Usbiological

Product number: 300947
Product name: Scutellarin methyl ester
Packaging: 10mg
Price: $446
Updated: 2021/12/16

ChemScene

Product number: CS-0027792
Product name: Scutellarinmethylester
Packaging: 10mg
Price: $457
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FS74250
Product name: Scutellarin methylester
Packaging: 250mg
Price: $462.5
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb259491
Product name: Scutellarin methyl ester
Purity: 98%
Packaging: 10mg
Price: $472.6
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb259491
Product name: Scutellarin methyl ester
Purity: 98%
Packaging: 20mg
Price: $591.6
Updated: 2021/12/16

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scutellarin Methylester Chemical Properties,Usage,Production

Effect

The improvement effect of scutellarin methylester on ischemic brain tissue showed that scutellarin methylester can effectively improve the local cerebral blood flow of ischemia-reperfusion in rats, and significantly reduce the degree of ischemic damage to brain tissue. The mechanism may be In order to inhibit cerebral vasospasm caused by protein kinase activation, increase local cerebral blood flow, improve cerebral microcirculation, and reduce inflammatory cell adhesion and infiltration, thereby reducing brain damage.

Mechanism of action

Scutellarin methylester mainly inhibits the formation of thrombus in vitro through three steps, reducing platelet count, inhibiting platelet aggregation function, inhibiting coagulation function in vivo, and promoting fibrinolytic activity, of which the latter two have stronger effects.

Uses

Scutellarin methyl ester is a constituent of Breviscapine which is a crude extract of several flavonoids of Erigeron breviscapus[1][2].

Definition

ChEBI: Scutellarin methyl ester is a glucosiduronic acid and a member of flavonoids.

Synthesis

67-56-1

27740-01-8

119262-68-9

GENERAL STEPS: Two 100 ml bottles of methanol were taken and cooled to 0°C under nitrogen protection and acetyl chloride (2.8 ml, 30 mmol) was added slowly. After keeping the reaction at 0°C for 30 min, a DMF solution (15 mL) of (2S,3S,4S,5R,6S)-6-((5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-benzopyran-7-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid (Compound 1, 4.62 g, 10 mmol) was added and stirred for 15 min. Slowly return to room temperature and gradually a white solid precipitated. The reaction mixture was heated to 40°C to continue the reaction for 4 hours, followed by cooling to -10°C for 1 hour. The reaction mixture was filtered and the filter cake was washed with water and dried under vacuum. A yellow solid (2S,3S,4S,5R,6S)-6-((5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-benzopyran-7-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid methyl ester was obtained (target product, 3.65 g) in 77% yield.

References

[1] Zhao M, et al. Structural identification of related substances in Breviscapine by UPLC-QTOF-MS. Zhongguo Zhong Yao Za Zhi. 2018 Jul;43(14):2872-2877. DOI:10.19540/j.cnki.cjcmm.2018.0089
[2] Gao J, et al. Therapeutic Effects of Breviscapine in Cardiovascular Diseases: A Review. Front Pharmacol. 2017 May 23;8:289. DOI:10.3389/fphar.2017.00289

scutellarin Methylester Preparation Products And Raw materials

Raw materials

Preparation Products

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scutellarin Methylester Suppliers

China 133 India 1 United Kingdom 1 United States 8 Global 143

Shanghai Fuorain BioTech Co., Ltd

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Shanghai Yongye Biotechnology Co., Ltd.

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Wuhan ChemFaces Biochemical Co., Ltd.

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View Lastest Price from scutellarin Methylester manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Scutellarin methylester 119262-68-9
Price: US $0.00/mg
Min. Order: 20mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-03-11

Career Henan Chemical Co

Product: Scutellarin methyl ester 119262-68-9
Price: US $9.80/KG
Min. Order: 1g
Purity: ＞98%
Supply Ability: 20 tons
Release date: 2020-02-10

119262-68-9, scutellarin MethylesterRelated Search:

MOSLOFLAVONE Naringenin 4',5-DIHYDROXY-7-METHOXYFLAVONE hydroxygenkwanin MEDICAGOL PONCIRIN Quercetin-7-O-β-D-glucopyranoside Methyl dihydrojasmonate Metaclazepam SCUTELLAREIN Methylparaben Methyl acrylate Methyl salicylate Dimethyl sulfate POLY(METHYL METHACRYLATE) Dimethyl carbonate Methyl methacrylate Scutellarin

5,6-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl beta-D-glucopyranosiduronic acid methyl ester

Breviscapine methyl ester

Scutellarin Methlester

scutellarin Methylester

β-D-Glucopyranosiduronic acid, 5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl, methyl ester

(2S,3S,4S,5R,6S)-Methyl 6-((5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylate

Scutellarin methyl ester, 10 mM in DMSO

119262-68-9

reagent

standard substance

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract