ChemicalBook > CAS DataBase List > CK-636

CK-636

Description In vitro

Product Name: CK-636
CAS No.: 442632-72-6
Chemical Name: CK-636
Synonyms: CK-636;CS-1421;CK-0944636;CK-636, >=98%;CK-636 USP/EP/BP;CK-636(CK-0944636;CK-636;CK636; CK 636;CK-636, 10 mM in DMSO;CK-636,CK-0944636, >98%;CK636; CK 636; CK-0944636; CK0944636; CK 0944636
CBNumber: CB12685323
Molecular Formula: C16H16N2OS
Formula Weight: 284.38
MOL File: 442632-72-6.mol

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CK-636 Property

storage temp.: Keep in dark place,Sealed in dry,2-8°C
solubility: DMSO: ≥20mg/mL
form: powder
color: peach to light tan
InChIKey: ACAKNPKRLPMONU-UHFFFAOYSA-N
CAS DataBase Reference: 442632-72-6

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C7374
Product name: CK-636
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $92.7
Updated: 2025/07/31

Sigma-Aldrich

Product number: C7374
Product name: CK-636
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $397
Updated: 2023/01/07

Cayman Chemical

Product number: 16243
Product name: CK-636
Purity: ≥98%
Packaging: 5mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 16243
Product name: CK-636
Purity: ≥98%
Packaging: 10mg
Price: $115
Updated: 2024/03/01

Cayman Chemical

Product number: 16243
Product name: CK-636
Purity: ≥98%
Packaging: 25mg
Price: $270
Updated: 2024/03/01

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CK-636 Chemical Properties,Usage,Production

Description

CK-636 is an Arp2/3 complex inhibitor with IC50 of 4 μM, 24 μM and 32 μM for inhibition of actin polymerization induced by human, fission yeast and bovine Arp2/3 complex, respectively.

In vitro

CK-636 inhibits actin polymerization mediated by Arp2/3 complex in live cells, and reduces the formation of actin filament comet tails by Listeria in infected SKOV3 cells. CK-636 inhibits lamellipodia formation at the leading edges of migrating T cells, and causes reduced velocity. In addition, a substantial fraction of CK-636-treated T cells on zigzag patterns with an acute turning angle are trapped near the interfaces formed by the turning points of zigzag patterns.

Uses

CK-636 is a small molecule that inhibits Actin-related protein 2/3 (Arp2/3) (1). Arp2/3 is a 7 subunits protein complex that regulates actin cytoskeleton (2). CK-636 interacts with Arp2/3 and prevents actin polymerization.

Biological Activity

CK-636 binds between Arp2 and Arp3, where it appears to block movement of Arp2 and Arp3 into their active conformation. CK-636 inserts into the hydrophobic core of Arp3 and alters its conformation. Both classes of compounds inhibit formation of actin filament comet tails by Listeria and podosomes by monocytes.

CK-636 Preparation Products And Raw materials

Raw materials

Preparation Products

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CK-636 Suppliers

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View Lastest Price from CK-636 manufacturers

Career Henan Chemical Co

Product: CK-636 442632-72-6
Price: US $5.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2019-09-03

442632-72-6, CK-636Related Search:

LY 294002 Hydrochloride CK-0157869 E 7010 Saracatinib Paclitaxel NSC 23766 (hydrochloride) 2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride

CK-636

N-(2-(2-METHYL-1H-INDOL-3-YL)ETHYL)THIOPHENE-2-CARBOXAMIDE

N-[2-(2-Methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide

CK-636, >=98%

CK-0944636

CK-636 N-[2-(2-Methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide

N-[2-(2-Methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide CK636

CK-636;CK636; CK 636

CK-636(CK-0944636

CS-1421

CK636; CK 636; CK-0944636; CK0944636; CK 0944636

CK-636,CK-0944636, >98%

2-Thiophenecarboxamide, N-[2-(2-methyl-1H-indol-3-yl)ethyl]-

CK-636 USP/EP/BP

CK 0944636,CK-636,Inhibitor,Actin-related protein 2/3 complex,CK0944636,CK636,Arp2/3 Complex,inhibit

CK-636, 10 mM in DMSO

442632-72-6

Inhibitors