CK-636
Description In vitro- Product Name
- CK-636
- CAS No.
- 442632-72-6
- Chemical Name
- CK-636
- Synonyms
- CK-636;CS-1421;CK-0944636;CK-636, >=98%;CK-636 USP/EP/BP;CK-636(CK-0944636;CK-636;CK636; CK 636;CK-636,CK-0944636, >98%;CK636; CK 636; CK-0944636; CK0944636; CK 0944636;N-[2-(2-Methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide
- CBNumber
- CB12685323
- Molecular Formula
- C16H16N2OS
- Formula Weight
- 284.38
- MOL File
- 442632-72-6.mol
CK-636 Property
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- solubility
- DMSO: ≥20mg/mL
- form
- powder
- color
- peach to light tan
- InChIKey
- ACAKNPKRLPMONU-UHFFFAOYSA-N
- CAS DataBase Reference
- 442632-72-6
N-Bromosuccinimide Price
- Product number
- C7374
- Product name
- CK-636
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $106
- Updated
- 2024/03/01
- Product number
- C7374
- Product name
- CK-636
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $397
- Updated
- 2023/01/07
- Product number
- 16243
- Product name
- CK-636
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 16243
- Product name
- CK-636
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $115
- Updated
- 2024/03/01
- Product number
- 16243
- Product name
- CK-636
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $270
- Updated
- 2024/03/01
CK-636 Chemical Properties,Usage,Production
Description
CK-636 is an Arp2/3 complex inhibitor with IC50 of 4 μM, 24 μM and 32 μM for inhibition of actin polymerization induced by human, fission yeast and bovine Arp2/3 complex, respectively.
In vitro
CK-636 inhibits actin polymerization mediated by Arp2/3 complex in live cells, and reduces the formation of actin filament comet tails by Listeria in infected SKOV3 cells. CK-636 inhibits lamellipodia formation at the leading edges of migrating T cells, and causes reduced velocity. In addition, a substantial fraction of CK-636-treated T cells on zigzag patterns with an acute turning angle are trapped near the interfaces formed by the turning points of zigzag patterns.
Uses
CK-636 is a small molecule that inhibits Actin-related protein 2/3 (Arp2/3) (1). Arp2/3 is a 7 subunits protein complex that regulates actin cytoskeleton (2). CK-636 interacts with Arp2/3 and prevents actin polymerization.
CK-636 Preparation Products And Raw materials
Raw materials
Preparation Products
CK-636 Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from CK-636 manufacturers
- Product
- CK-636 442632-72-6
- Price
- US $5.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2019-09-03