ChemicalBook > CAS DataBase List > 1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride
1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride
- Product Name
- 1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride
- CAS No.
- 1628047-87-9
- Chemical Name
- 1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride
- Synonyms
- abt199 int 1;5-dimethyl-3;1-((4-chloro-5;ABT199 intermediate1;ABT-199 Intermeidate1;Venetoclax Intermediate 2;Venetoclax Impurity 23 DiHCl;Venetoclax Impurity 31(Hydrochloride);1-biphenyl]-2-yl)methyl)piperazine dihydrochloride;1-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]piperazine diHCL
- CBNumber
- CB12742389
- Molecular Formula
- C19H28Cl2N2
- Formula Weight
- 355.35
- MOL File
- 1628047-87-9.mol
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1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride Property
- storage temp.
- Inert atmosphere,Room Temperature
- CAS DataBase Reference
- 1628047-87-9
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
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N-Bromosuccinimide Price
TRC
- Product number
- C371385
- Product name
- 1-{[2-(4-Chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazineDihydrochloride
- Packaging
- 2.5g
- Price
- $470
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 132846
- Product name
- 1-((4'-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazinedihydrochloride
- Purity
- 97%
- Packaging
- 1g
- Price
- $1224
- Updated
- 2021/12/16
AK Scientific
- Product number
- J11760
- Product name
- VenetoclaxIntermediate
- Packaging
- 100g
- Price
- $425
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 132846
- Product name
- 1-((4'-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazinedihydrochloride
- Purity
- 97%
- Packaging
- 250mg
- Price
- $432
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- HCH0419415
- Product name
- 1-([2-(4-CHLOROPHENYL)-4,4-DIMETHYLCYCLOHEX-1-EN-1-YL]METHYL)PIPERAZINE DIHYDROCHLORIDE SALT
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $457.89
- Updated
- 2021/12/16
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1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride Chemical Properties,Usage,Production
Uses
1-{[2-(4-Chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazine Dihydrochloride is an intermediate used in the preparation of Venetoclax (A112430), which is a potent and selective BCL-2 inhibitor with potent antitumour activity while sparing platelets. Venetoclax is used to treat chronic lymphocytic leukaemic cells and estrogen receptor-positive breast cancer.
Synthesis
To a solution of tert-butyl 4-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1 -enyl)methyl)piperazine-1 - carboxylate 6 (30 g, 0.072 mol) in MeOH (20 mL) was added conc.HCI (50 mL). The reaction was stirred for 24 hours and then concentrated under reduced pressure. A saturated solution of NazCCh was added to adjust the pH to 8-9, and the mixture was extracted with dichloromethane (2x200 mL). The combined extracts were washed with brine, dried (NazSC ), filtered, and concentrated under reduced pressure. The oil product was treated with MeOH/HCI (g) (3.0 M, 500 mL) and stirred for 1 hour, then concentrated under reduced pressure to get the product 1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride (23 g, 83%).
1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride manufacturers
ShenZhen H&D Pharmaceutical Technology Co., LTD
- Product
- Venetoclax Impurity 31(Hydrochloride) 1628047-87-9
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 0.98
- Supply Ability
- 10g
- Release date
- 2024-04-28
Hangzhou ICH Biofarm Co., Ltd
- Product
- 1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine 1628047-87-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2023-06-30
Hebei Mingeng Biotechnology Co., Ltd
- Product
- 1-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]piperazine dihydrochloride 1628047-87-9
- Price
- US $150.00/ASSAYS
- Min. Order
- 10g
- Purity
- >99%
- Supply Ability
- 500kg/month
- Release date
- 2021-11-24
1628047-87-9, 1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochlorideRelated Search:
INTERMEDIATES
1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine
FETAL BOVINE SERUM USA ORIGIN GAMMA
1-Piperazinecarboxylic acid, 4-[3-fluoro-4-(methoxycarbonyl)phenyl]-, 1,1-dimethylethyl ester
(2-(4-chlorophenyl)-4,4-diMethylcyclohex-1-enyl)Methanol
5-AMINO-3-(TRIFLUOROMETHYL)PICOLINONITRILE
Apalutamide
N/A
5-isothiocyanato-3-(trifluoromethyl)picolinonitrile
methyl 2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-4-(piperazin-1-yl)benzoate
tert-butyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-bromobenzoate
ABT-199
4-(1-CYANOCYCLOBUTYLAMINO)-2-FLUORO-N-METHYLBENZAMIDE
Methyl 4-Fluoro-2-{1H-pyrrolo[2,3-b]pyridin-5-yloxy}benzoate
3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide
4-Bromo-2-fluoro-N-methylbenzamide