1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride

Product Name: 1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride
CAS No.: 1628047-87-9
Chemical Name: 1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride
Synonyms: abt199 int 1;5-dimethyl-3;1-((4-chloro-5;ABT199 intermediate1;ABT-199 Intermeidate1;Venetoclax Intermediate 2;Venetoclax Impurity 23 DiHCl;Venetoclax Impurity 31(Hydrochloride);1-biphenyl]-2-yl)methyl)piperazine dihydrochloride;1-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]piperazine diHCL
CBNumber: CB12742389
Molecular Formula: C19H28Cl2N2
Formula Weight: 355.35
MOL File: 1628047-87-9.mol

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1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride Property

storage temp.: Inert atmosphere,Room Temperature
CAS DataBase Reference: 1628047-87-9

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC

Product number: C371385
Product name: 1-{[2-(4-Chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazineDihydrochloride
Packaging: 2.5g
Price: $470
Updated: 2021/12/16

Matrix Scientific

Product number: 132846
Product name: 1-((4'-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazinedihydrochloride
Purity: 97%
Packaging: 1g
Price: $1224
Updated: 2021/12/16

AK Scientific

Product number: J11760
Product name: VenetoclaxIntermediate
Packaging: 100g
Price: $425
Updated: 2021/12/16

Matrix Scientific

Product number: 132846
Product name: 1-((4'-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazinedihydrochloride
Purity: 97%
Packaging: 250mg
Price: $432
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0419415
Product name: 1-([2-(4-CHLOROPHENYL)-4,4-DIMETHYLCYCLOHEX-1-EN-1-YL]METHYL)PIPERAZINE DIHYDROCHLORIDE SALT
Purity: 95.00%
Packaging: 5MG
Price: $457.89
Updated: 2021/12/16

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1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride Chemical Properties,Usage,Production

Uses

1-{[2-(4-Chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazine Dihydrochloride is an intermediate used in the preparation of Venetoclax (A112430), which is a potent and selective BCL-2 inhibitor with potent antitumour activity while sparing platelets. Venetoclax is used to treat chronic lymphocytic leukaemic cells and estrogen receptor-positive breast cancer.

Synthesis

To a solution of tert-butyl 4-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1 -enyl)methyl)piperazine-1 - carboxylate 6 (30 g, 0.072 mol) in MeOH (20 mL) was added conc.HCI (50 mL). The reaction was stirred for 24 hours and then concentrated under reduced pressure. A saturated solution of NazCCh was added to adjust the pH to 8-9, and the mixture was extracted with dichloromethane (2x200 mL). The combined extracts were washed with brine, dried (NazSC ), filtered, and concentrated under reduced pressure. The oil product was treated with MeOH/HCI (g) (3.0 M, 500 mL) and stirred for 1 hour, then concentrated under reduced pressure to get the product 1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride (23 g, 83%).

1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride Suppliers

China 167 India 5 United States 5 Global 177

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View Lastest Price from 1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Venetoclax Impurity 31(Hydrochloride) 1628047-87-9
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 10g
Release date: 2024-04-28

Hangzhou ICH Biofarm Co., Ltd

Product: 1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine 1628047-87-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 200kg
Release date: 2023-06-30

Hebei Mingeng Biotechnology Co., Ltd

Product: 1-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]piperazine dihydrochloride 1628047-87-9
Price: US $150.00/ASSAYS
Min. Order: 10g
Purity: >99%
Supply Ability: 500kg/month
Release date: 2021-11-24

1628047-87-9, 1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochlorideRelated Search:

INTERMEDIATES 1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine FETAL BOVINE SERUM USA ORIGIN GAMMA 1-Piperazinecarboxylic acid, 4-[3-fluoro-4-(methoxycarbonyl)phenyl]-, 1,1-dimethylethyl ester (2-(4-chlorophenyl)-4,4-diMethylcyclohex-1-enyl)Methanol 5-AMINO-3-(TRIFLUOROMETHYL)PICOLINONITRILE Apalutamide N/A 5-isothiocyanato-3-(trifluoromethyl)picolinonitrile methyl 2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-4-(piperazin-1-yl)benzoate tert-butyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-bromobenzoate ABT-199 4-(1-CYANOCYCLOBUTYLAMINO)-2-FLUORO-N-METHYLBENZAMIDE Methyl 4-Fluoro-2-{1H-pyrrolo[2,3-b]pyridin-5-yloxy}benzoate 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide 4-Bromo-2-fluoro-N-methylbenzamide

1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride

ABT199 intermediate1

abt199 int 1

1-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl)methyl)piperazine dihydrochloride

1-((4'-chloro-5,5-demethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl-2yl]methyl)piperazine dihydrochloride

1-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazine dihydrochloride

Piperazine, 1-[[2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-, hydrochloride (1:2)

1-((4'-Chloro-5,5-dimethyl-3,4,5,6-tetrah ydro-[1,1'-biphenyl]-2-yl)methy)piperazine dihydrochloride

1-{[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl}piperazine dihydrochloride

1-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]piperazine diHCL

ABT-199 Intermeidate1

1-[[2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl] methyl]-Piperazine, hydrochloride (1:2)

1-((4-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine 2HCl

Piperazine, 1-[[2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]- (Dihydrochloride)

Venetoclax Intermediate 2

1-((4'-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydroch

1-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl)methyl)piperazine hydrochloride

1-[[2-(4-chlorophenyl)-4,4-dimethyl-cyclohexen-1-yl]methyl]piperazine dihydrochloride

1-((4-chloro-5

1-biphenyl]-2-yl)methyl)piperazine dihydrochloride

5-dimethyl-3

1 - ((4 '- chloro-5,5-dimethyl-3,4,5,6-tetrahydro - [1,1' - diphenyl] - 2-yl) methyl) piperazine dihydrochloride

Venetoclax Impurity 31(Hydrochloride)

Venetoclax Impurity 23 DiHCl

1-((2-chlorophelyl)-4,4-diemethylcyclohex-1-en-1-yl)methyl)piperazine dihydrochloride

1-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen- yl]methyl]-piperazine,dihydrochlorid

1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride

1-((4'-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methy)piperazine dihydrochloride

1628047-87-9

C19H27ClN22ClH

C19H27ClN22HCl

C19H29Cl3N2