ChemicalBook > CAS DataBase List > 2-Amino-3-cyano-4,5-dimethylpyrrole

2-Amino-3-cyano-4,5-dimethylpyrrole

Product Name: 2-Amino-3-cyano-4,5-dimethylpyrrole
CAS No.: 21392-51-8
Chemical Name: 2-Amino-3-cyano-4,5-dimethylpyrrole
Synonyms: AT-51109;2-AMino-3-cyano-4,5-;2-amino-4,5-dimethyl-1H-pyrrol;2-AMINO-3-CYANO-4,5-DIMETHYLPYRROLE;2-AMINO-3-CYANO-4,5-DIMETHYL-1H-PYRROLE;2-Amino-4,5-dimethylpyrrole-3-carbonitrile;2-AMINO-4,5-DIMETHYL-1H-PYRROLE-3-CARBONITRILE;1H-Pyrrole-3-carbonitrile, 2-amino-4,5-dimethyl-
CBNumber: CB1278693
Molecular Formula: C7H9N3
Formula Weight: 135.17
MOL File: 21392-51-8.mol

Less

2-Amino-3-cyano-4,5-dimethylpyrrole Property

Melting point:: 178-181°C
Boiling point:: 366.2±42.0 °C(Predicted)
Density: 1.17±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 18.46±0.50(Predicted)
Appearance: Brown to reddish brown Solid
CAS DataBase Reference: 21392-51-8(CAS DataBase Reference)

Less

Safety

Hazard Codes: Xi,Xn
Risk Statements: 20/21/22-41-37/38-22
Safety Statements: 26-36/37/39-39
RIDADR: 3439
HazardClass: IRRITANT
HS Code: 2933998090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

Less

N-Bromosuccinimide Price

TRC

Product number: A634695
Product name: 2-Amino-4,5-dimethyl-1H-pyrrole-3-carbonitrile
Packaging: 500mg
Price: $75
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H37-1-P8
Product name: 2-Amino-4,5-dimethyl-1H-pyrrole-3-carbonitrile
Packaging: 1g
Price: $16
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H37-1-P8
Product name: 2-Amino-4,5-dimethyl-1H-pyrrole-3-carbonitrile
Packaging: 5G
Price: $31
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA140292
Product name: 2-Amino-4,5-dimethyl-1H-pyrrole-3-carbonitrile
Packaging: 10g
Price: $68.8
Updated: 2021/12/16

Matrix Scientific

Product number: 043941
Product name: 2-Amino-4,5-dimethyl-1H-pyrrole-3-carbonitrile
Purity: >95%
Packaging: 500mg
Price: $118
Updated: 2021/12/16

Less

2-Amino-3-cyano-4,5-dimethylpyrrole Chemical Properties,Usage,Production

Synthesis

6628-81-5

109-77-3

21392-51-8

A mixture of acetic anhydride (16.9 g, 165 mmol), acetic acid (2.26 g, 37.6 mmol), triethylamine (19 g, 188 mmol), and 4-(dimethylamino)pyridine (0.1 g, 0.75 mmol) was added to a reaction flask and heated to 50 °C. Racemic alanine (6.79 g, 76.2 mmol) was added in small batches over a period of 4 h under stirring while maintaining the reaction temperature in the range of 45-55 °C. The reaction was carried out at a constant temperature in the range of 45-55 °C. The reaction temperature was kept at a constant temperature in the range of 45-55 °C. After the alanine addition was completed, the red mixture was continued to be stirred at 50 °C for 8 hours. Subsequently, acetic anhydride, acetic acid and triethylamine were removed by vacuum distillation (15-20 mbar) and the temperature of the system was gradually raised to a maximum of 100 °C. The residue of the resulting acylamino ketone intermediate (246) was cooled to room temperature and water (40 mL) was added. Next, malononitrile (4.71 g, 71.3 mmol) was added and the reaction mixture was slowly poured into 30% aqueous sodium hydroxide solution (25 mL), ensuring that the reaction temperature did not exceed 60 °C. The resulting mixture was cooled to 0 °C, filtered, washed with water (45 mL), and dried under vacuum to give 6.65 g of pyrrole derivative (7) in beige solid form in 66% yield; the melting point was 163-165 °C (literature value) [24].

References

[1] Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1990, vol. 29, # 1, p. 47 - 52
[2] Bioorganic Chemistry, 2018, vol. 81, p. 612 - 629
[3] Pharmazie, 1989, vol. 44, # 12, p. 814 - 816
[4] Chimia, 2004, vol. 58, # 9, p. 640 - 648
[5] Organic Process Research and Development, 2001, vol. 5, # 6, p. 581 - 586

2-Amino-3-cyano-4,5-dimethylpyrrole Preparation Products And Raw materials

Raw materials

Preparation Products

Less

2-Amino-3-cyano-4,5-dimethylpyrrole Suppliers

Canada 1 China 65 France 1 Germany 1 India 1 Russia 1 United Kingdom 8 United States 14 Global 92

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

Tel: +86-21-54098501
Fax: +86-21-54096319
Email: sales@sinch.com.cn
Country: China
ProdList: 11598
Advantage: 64

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 18270980682
Fax: 021 51613951
Email: mlcheng@sunwaypharm.cn
Country: China
ProdList: 8669
Advantage: 57

Suzhou Sibian Chemical Technology Co.,Ltd.

Tel: 0512-65617459 18915409046
Fax: 0512-65617459
Email: sales@sibian-chem.com
Country: China
ProdList: 1922
Advantage: 55

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
Advantage: 58

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 18209
Advantage: 56

Cantotech Chemicals, Ltd.

Tel: 86-0755-86635001
Fax: 86-0755-22642228
Email: cantotech@126.com
Country: China
ProdList: 4566
Advantage: 55

Shanghai Witofly Chemical Co.,Ltd

Tel
Email: sales@witofly.com
Country: China
ProdList: 2864
Advantage: 52

Chimica Laboratories Co., Ltd

Tel: 0086-573-82585213
Fax: 0086-573-82585233
Email: bai@chimicalabs.com
Country: China
ProdList: 861
Advantage: 64

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Shanghai Xingui Biotechnology Co., Ltd.

Tel: 15121041756
Email: xingui2022@126.com
Country: China
ProdList: 9979
Advantage: 58

Tianjing Geneston Bio-tech Co.,Ltd.

Tel: 022-60131465 18920720807
Fax: 022-58558581
Email: zishan_1986@163.com
Country: China
ProdList: 743
Advantage: 58

Chengdu J&B Technology Co., Ltd.

Tel: 028-61186694 15608078506
Fax: 028-61186694
Email: 609128801@qq.com
Country: China
ProdList: 837
Advantage: 55

Jiaxing Rich Biological Technology Co., Ltd.

Tel: 0573-11111111-1111 18969316891
Fax: -
Email: richmol@163.com
Country: China
ProdList: 449
Advantage: 50

Wonder Scientific Co., Ltd.

Tel: 86-027-59601310
Fax: +86 (27) 8740-1357
Country: China
ProdList: 41
Advantage: 58

Wuhan Chemwish Technology Co.， Ltd

Tel: 027-67849912
Fax: 027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 9148
Advantage: 60

Nanjing Vital Chemical Co., Ltd.

Tel: 025-87193546 18652950785
Fax: 025-87193546
Email: chemweiao@163.com
Country: China
ProdList: 9021
Advantage: 60

Henan CoreyChem Co., Ltd

Tel: 0371-86658258
Fax: 0371-60996044
Email: info@coreychem.com
Country: China
ProdList: 10453
Advantage: 58

Nanjing XiLang Chemical Products Co., Ltd.

Tel: 18936048580
Email: chemxilang@163.com
Country: China
ProdList: 3909
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Beijing Hechemist Technology CO.,LTD

Tel: 18511709189
Fax: 010-58043593
Email: sales@hechemist.com
Country: China
ProdList: 2835
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Hangzhou Molcore Biopharmatech Co.,Ltd

Tel: 400-711-5280 86-571-81025280
Fax: 86-571-85806285
Email: sales@molcore.com
Country: China
ProdList: 9967
Advantage: 58

Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718; +8613336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
ProdList: 29735
Advantage: 60

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: 02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 16027
Advantage: 58

Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.

Tel: 027-51831887 15337167856
Fax: 027-51837635 QQ1165326703
Email: hubeixinyuanshun@163.com
Country: China
ProdList: 10295
Advantage: 58

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-037163312495,13303845143 13303845143
Fax: QQ3001379618
Email: 3001379618@qq.com
Country: China
ProdList: 10267
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418671 +8618949823763
Fax: 0551-65418697
Email: sales@tnjchem.com
Country: China
ProdList: 34563
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: +86-0571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52846
Advantage: 58

Henan Weituxi Chemical Technology Co., Ltd.

Tel: 0371-63284658 18135795563
Fax: QQ:2885349392
Email: 2885349392@qq.com
Country: China
ProdList: 9992
Advantage: 58

Chemwill Asia Co.,Ltd.

Tel: 86-21-51086038
Fax: 86-21-51861608
Email: chemwill_asia@126.com
Country: CHINA
ProdList: 23912
Advantage: 58

Wuhan Chemwish Technology Co., Ltd

Tel: 027-67849912
Email: sales@chemwish.com
Country: CHINA
ProdList: 10821
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49975
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29798
Advantage: 58

Zhenjiang Borun Bio-Technology Pharmaceutical Co., Ltd.

Tel: 15862994627
Fax: QQ:2570984291
Email: 2570984291@qq.com
Country: China
ProdList: 972
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 40000
Advantage: 58

THchemica Co.,Ltd.

Tel: 0573-82835115 18969301519
Email: tly1019@126.com
Country: China
ProdList: 276
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-6005915
Email: sales@picasso-e.com
Country: China
ProdList: 39665
Advantage: 58

Wuhan Brin Technology Co., Ltd.

Tel: 3456065315 13260619011
Email: 3456065315@qq.com
Country: China
ProdList: 2199
Advantage: 58

Jiaxing Deyi Chemical Co., Ltd

Tel: 0573-85866609 13588473046
Email: 824930988@qq.com
Country: China
ProdList: 7865
Advantage: 58

Xuchang Fengfei New Materials Technology Co., Ltd

Tel: 19713077352
Email: 1038096457@qq.com
Country: China
ProdList: 2640
Advantage: 58

Shaanxi Didu New Material Co., Ltd

Tel: 029-81145920 17391631969
Email: 1046@dideu.com
Country: China
ProdList: 9996
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 17801761073
Email: Gsiyu@solarbio.com
Country: China
ProdList: 50464
Advantage: 58

Shanghai Jieshikai Biotechnology Co. , Ltd.

Tel: 021-57520305 13795461237
Email: zhuruyan@jskchem.com
Country: China
ProdList: 49234
Advantage: 58

Less

View Lastest Price from 2-Amino-3-cyano-4,5-dimethylpyrrole manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-Amino-3-cyano-4,5-dimethylpyrrole 21392-51-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: 2-Amino-3-cyano-4,5-dimethylpyrrole 21392-51-8
Price: US $1.00/IU
Min. Order: 1KG
Purity: 99%
Supply Ability: 500kg
Release date: 2019-12-31

21392-51-8, 2-Amino-3-cyano-4,5-dimethylpyrroleRelated Search:

Dimethyl sulfate Dimethyl phthalate Dimethyl fumarate Dimethyl ether Dimethyl carbonate 3-Aminophenol Polyvinylpyrrolidone ETHANE Pyrrole N-Methyl-2-pyrrolidone N,N-Dimethylformamide ALTRENOGEST 2,5-Dimethyl-1H-pyrrole 2,5-Dimethylpyrrolidine Povidone iodine Dacthal N-Vinyl-2-pyrrolidone Tris(hydroxymethyl)aminomethane

2-AMINO-3-CYANO-4,5-DIMETHYL-1H-PYRROLE

2-AMINO-3-CYANO-4,5-DIMETHYLPYRROLE

AT-51109

2-AMINO-4,5-DIMETHYL-1H-PYRROLE-3-CARBONITRILE

2-amino-4,5-dimethyl-1H-pyrrol

1H-Pyrrole-3-carbonitrile, 2-amino-4,5-dimethyl-

2-AMino-3-cyano-4,5-

2-Amino-4,5-dimethylpyrrole-3-carbonitrile

21392-51-8

C7H9N3

Pyrroles & Indoles

Non-Chiral heterocyclic compounds

Benzenes

Amines

Pyrroles & Indoles

API intermediates

Heterocycle intermediates