2-Amino-3-cyano-4,5-dimethylpyrrole
- Product Name
- 2-Amino-3-cyano-4,5-dimethylpyrrole
- CAS No.
- 21392-51-8
- Chemical Name
- 2-Amino-3-cyano-4,5-dimethylpyrrole
- Synonyms
- AT-51109;2-AMino-3-cyano-4,5-;2-amino-4,5-dimethyl-1H-pyrrol;2-AMINO-3-CYANO-4,5-DIMETHYLPYRROLE;2-AMINO-3-CYANO-4,5-DIMETHYL-1H-PYRROLE;2-Amino-4,5-dimethylpyrrole-3-carbonitrile;2-AMINO-4,5-DIMETHYL-1H-PYRROLE-3-CARBONITRILE;1H-Pyrrole-3-carbonitrile, 2-amino-4,5-dimethyl-
- CBNumber
- CB1278693
- Molecular Formula
- C7H9N3
- Formula Weight
- 135.17
- MOL File
- 21392-51-8.mol
2-Amino-3-cyano-4,5-dimethylpyrrole Property
- Melting point:
- 178-181°C
- Boiling point:
- 366.2±42.0 °C(Predicted)
- Density
- 1.17±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 18.46±0.50(Predicted)
- Appearance
- Brown to reddish brown Solid
- CAS DataBase Reference
- 21392-51-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 20/21/22-41-37/38-22
- Safety Statements
- 26-36/37/39-39
- RIDADR
- 3439
- HazardClass
- IRRITANT
- HS Code
- 2933998090
N-Bromosuccinimide Price
- Product number
- A634695
- Product name
- 2-Amino-4,5-dimethyl-1H-pyrrole-3-carbonitrile
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 3H37-1-P8
- Product name
- 2-Amino-4,5-dimethyl-1H-pyrrole-3-carbonitrile
- Packaging
- 1g
- Price
- $16
- Updated
- 2021/12/16
- Product number
- 3H37-1-P8
- Product name
- 2-Amino-4,5-dimethyl-1H-pyrrole-3-carbonitrile
- Packaging
- 5G
- Price
- $31
- Updated
- 2021/12/16
- Product number
- FA140292
- Product name
- 2-Amino-4,5-dimethyl-1H-pyrrole-3-carbonitrile
- Packaging
- 10g
- Price
- $68.8
- Updated
- 2021/12/16
- Product number
- 043941
- Product name
- 2-Amino-4,5-dimethyl-1H-pyrrole-3-carbonitrile
- Purity
- >95%
- Packaging
- 500mg
- Price
- $118
- Updated
- 2021/12/16
2-Amino-3-cyano-4,5-dimethylpyrrole Chemical Properties,Usage,Production
Synthesis
6628-81-5
109-77-3
21392-51-8
A mixture of acetic anhydride (16.9 g, 165 mmol), acetic acid (2.26 g, 37.6 mmol), triethylamine (19 g, 188 mmol), and 4-(dimethylamino)pyridine (0.1 g, 0.75 mmol) was added to a reaction flask and heated to 50 °C. Racemic alanine (6.79 g, 76.2 mmol) was added in small batches over a period of 4 h under stirring while maintaining the reaction temperature in the range of 45-55 °C. The reaction was carried out at a constant temperature in the range of 45-55 °C. The reaction temperature was kept at a constant temperature in the range of 45-55 °C. After the alanine addition was completed, the red mixture was continued to be stirred at 50 °C for 8 hours. Subsequently, acetic anhydride, acetic acid and triethylamine were removed by vacuum distillation (15-20 mbar) and the temperature of the system was gradually raised to a maximum of 100 °C. The residue of the resulting acylamino ketone intermediate (246) was cooled to room temperature and water (40 mL) was added. Next, malononitrile (4.71 g, 71.3 mmol) was added and the reaction mixture was slowly poured into 30% aqueous sodium hydroxide solution (25 mL), ensuring that the reaction temperature did not exceed 60 °C. The resulting mixture was cooled to 0 °C, filtered, washed with water (45 mL), and dried under vacuum to give 6.65 g of pyrrole derivative (7) in beige solid form in 66% yield; the melting point was 163-165 °C (literature value) [24].
References
[1] Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1990, vol. 29, # 1, p. 47 - 52
[2] Bioorganic Chemistry, 2018, vol. 81, p. 612 - 629
[3] Pharmazie, 1989, vol. 44, # 12, p. 814 - 816
[4] Chimia, 2004, vol. 58, # 9, p. 640 - 648
[5] Organic Process Research and Development, 2001, vol. 5, # 6, p. 581 - 586
2-Amino-3-cyano-4,5-dimethylpyrrole Preparation Products And Raw materials
Raw materials
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View Lastest Price from 2-Amino-3-cyano-4,5-dimethylpyrrole manufacturers
- Product
- 2-Amino-3-cyano-4,5-dimethylpyrrole 21392-51-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- 2-Amino-3-cyano-4,5-dimethylpyrrole 21392-51-8
- Price
- US $1.00/IU
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500kg
- Release date
- 2019-12-31