Goserelin acetate

ChemicalBook > CAS DataBase List > Goserelin acetate

Product Name: Goserelin acetate
CAS No.: 145781-92-6
Chemical Name: Goserelin acetate
Synonyms: Fertilan;Goserelin HCl;Goserelin acetate;Gosorelin Acetate;Goserelin Acteate;Goserilyn acetate;ICI-118630 acetate;Goserelin acetate/Fertilan;Goserelin?Acetate impurity;Goserelin Acetate(acetate)
CBNumber: CB1281026
Molecular Formula: C61H88N18O16
Formula Weight: 1329.49
MOL File: 145781-92-6.mol

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Goserelin acetate Property

Melting point:: >190°C (dec.)
storage temp.: -20°C
solubility: H₂O: 20 mg/mL, clear, colorless
form: white powder
color: White to Off-White
Stability:: Hygroscopic
InChIKey: IKDXDQDKCZPQSZ-JHYYTBFNSA-N

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
RTECS: OK6369800
HS Code: 2937190000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: G4919
Product name: Goserelin acetate
Purity: ≥99% (HPLC), white powder
Packaging: 5mg
Price: $110.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1297205
Product name: Goserelin acetate
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 100mg
Price: $1450
Updated: 2024/03/01

Cayman Chemical

Product number: 24071
Product name: Goserelin (acetate)
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 24071
Product name: Goserelin (acetate)
Purity: ≥98%
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Sigma-Aldrich

Product number: Y0001473
Product name: Goserelin for NMR identification
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0001473
Price: $223
Updated: 2024/03/01

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Goserelin acetate Chemical Properties,Usage,Production

Description

Goserelin acetate, like leuprolide acetate, is a synthetic superagonist nonapeptide analogue of GnRH that possesses greater potency than the natural hormone. Note that it contains D-Ser(But) and NH-NHCONH2 in place of Gly6 and Gly10-NH2, respectively. That is, the C terminal modification simply has an NH substituting for the CH2 of Gly, and like the C-terminal change in leuprolide acetate, this inhibits enzymatic degradation of the peptide by the postproline carboxyamide peptidase.
Goserelin acetate is available in the form of a small, solid pellet that is administered as an SC implant for the palliative treatment of advanced, metastatic breast cancer in pre- and perimenopausal women or, similarly, as a palliative in advanced prostatic cancer. The rationale for this drug's use is, as described above, its ability as a superagonist to bring the levels of estradiol or testosterone to near castrate levels, thus slowing the progression of breast or prostate carcinoma, respectively. Additionally, goserelin acetate is approved for use in treating endometriosis for up to 6 months.

Description

Goserelin is a synthetic gonadotropin-releasing hormone (GNRH) agonist that binds to the GNRH receptor (GNRHR; K_i = 1.6 nM, in CHO cells expressing the human receptor). It binds to mouse pituitary αT3-1 cells and human placenta (K_ds = 2 and 580 nM, respectively) and increases intracellular calcium in αT3-1 cells. Goserelin induces testosterone production in vitro within 4 h in rat Leydig cells (ED₅₀ = 83 nM) but decreases testosterone plasma level in vivo in rats over a period of 2 to 24 weeks. It inhibits tumor growth in a DU145 human prostate carcinoma mouse xenograft model when administered at a dose of 100 μg per day. Formulations containing goserelin have been used in the treatment of hormone-dependent breast and prostate cancers, as well as endometriosis and uterine fibroids.

Chemical Properties

White Solid

Uses

Anticancer

Uses

injectable gonadotropin releasing hormone superagonist (GnRH agonist) or luteinizing hormone antiproliferative activity in breast, prostate and endometrial cancers

Uses

Synthetic peptide agonist analog of LH-RH. Antineoplastic (hormonal).

General Description

Goserelin acetate is a synthetic decapaptide, which is a potent analog of LHRH (luteinizing hormone releasing hormone).

Biochem/physiol Actions

Goserelin acetate peptide results in significant inhibition of gonadotropin release and suppresses steroidogenesis in ovaries and testis. Thus, it leads to a reduction of testosterone to castration levels and estrogen to postmenopausal levels. Therefore, this peptide is used for reducing testosterone levels in patients with locally advanced prostate cancer.

Clinical Use

Goserelin acetate also is used in combination with the antiandrogen flutamide for shrinking prostate carcinoma before radiation therapy. This maximal androgen blockade combination is used when the prostate carcinoma has been staged as locally confined to the prostate gland, with one or both lobes as well as the seminal vesicles involved. The treatment should start 8 weeks before radiation treatment begins and be continued throughout the radiation therapy.
Furthermore, women who are to undergo hysterectomy for menorrhagia can benefit from previous treatment with goserelin acetate, because it is able to induce endometrial thinning. This thinning of the endometrium improves the operating environment by causing less intrauterine bleeding, increased postoperative amenorrhea, and decreased dysmenorrhea following surgery, which is why goserelin acetate is approved for inducing endometrial thinning prior to a patient undergoing a hysterectomy for heavy menstrual bleeding.

Goserelin acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Goserelin acetate manufacturers

Sinoway Industrial co., ltd.

Product: Goserelin acetate 145781-92-6
Price: US $0.00/kg
Min. Order: 2kg
Purity: 98% up by HPLC, EP
Supply Ability: 20tons
Release date: 2024-02-29

WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD

Product: Goserelin acetate 145781-92-6
Price: US $0.00/KG
Min. Order: 100g
Purity: 98%+
Supply Ability: 100kg
Release date: 2020-10-14

Nantong Guangyuan Chemicl Co,Ltd

Product: Goserelin Acetate 145781-92-6
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2023-11-15

145781-92-6, Goserelin acetateRelated Search:

1-Methoxy-2-propyl acetate Acetic acid Butyl acetate Tocopheryl acetate Ethyl acetate Methyl acetate Vinyl acetate Calcium acetate Potassium Acetate Sodium acetate trihydrate Glatiramer acetate Sodium acetate Cetrorelix acetate Pralmorelin Abarelix Argipressine acetate DESMOPRESSIN Fertirelin acetate

PYR-HIS-TRP-SER-TYR-D-SER(TBU)-LEU-ARG-PRO-AZAGLY-NH2

[(T-BU)DSER6, (AZA)GLY10]-LH-RH

[(T-BU)DSER6, (AZA)GLY10]-LUTEINIZING HORMONE-RELEASING HORMONE

ICI-118630 acetate

GOSERELIN HCL[PYR-HIS-TRP-SER-TYR-D-SER(T-BU)-LEU-ARG-PRO-AZAGLY-NH2]

1-9-Luteinizing hormone-releasing factor (swine), 6-(o-(1,1-dimethylethyl)-D-serine)-, 2-(aminocarbonyl)hydrazide, acetate (salt)

Fertilan

GLP-HIS-TRP-SER-TYR-D-SER(TBU)-LEU-ARG-PRO-AZA-GLY-NH2

(D-SER(TBU)6,AZAGLY10)-LHRH

(D-Ser(tBu)<sup>6</sup>,Azagly<sup>10</sup>)-LHRH acetate salt

Goserelin HCl

Goserelin Acetate (100 mg) (COLD SHIPMENT REQUIRED)

(2S)-1-[(2R)-2-[(2R)-2-[(2R)-3-(tert-butoxy)-2-[(2R)-2-[(2R)-3-hydroxy-2-[(2S)-2-[(2S)-3-(1H-iMidazol-5-yl)-2-{[(2R)-5-oxopyrrolidin-2-yl]forMaMido}propanaMido]-3-(1H-indol-3-yl)propanaMido]propanaMido]-3-(4-hydroxyphenyl)propanaMido]propanaMido]-4-Methyl

Goserelin acetate

Gosorelin Acetate

Goserelin Acteate

Goserelin for NMR identification

Goserelin acetate (ICI-118630 acetate)

Goserelin acetate/Fertilan

Goserelin?Acetate impurity

Goserilyn acetate

Goserelin acetate USP/EP/BP

Goserelin Acetate(acetate)

(D-Ser(tBu)?,Azagly??)-LHRH acetate salt

145781-92-6

C61H88N18O16

C59H84N18O14C2H4O2

C59H84N18O14xC2H4O2

C59H84N18O14xH2O

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