EPZ020411

Product Name: EPZ020411
CAS No.: 1700663-41-7
Chemical Name: EPZ020411
Synonyms: CS-2262;EPZ020411;EPZ020411 2HCl;EPZ020411 HCl;EPZ 020411;EPZ-020411;N1,N2-dimethyl-N1-((3-(4-((1r,3r)-3-(2-(tetrahydro-2H-pyran-4-yl)ethoxy)cyclobutoxy)phenyl)-1H-pyrazol-4-yl)methyl)ethane-1,2-diamine;1,2-Ethanediamine, N1,N2-dimethyl-N1-[[3-[4-[[trans-3-[2-(tetrahydro-2H-pyran-4-yl)ethoxy]cyclobutyl]oxy]phenyl]-1H-pyrazol-4-yl]methyl]-
CBNumber: CB13048651
Molecular Formula: C25H38N4O3
Formula Weight: 442.59
MOL File: 1700663-41-7.mol

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EPZ020411 Property

Boiling point:: 619.2±55.0 °C(Predicted)
Density: 1.16±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: crystalline solid
pka: 14.53±0.50(Predicted)
color: Off-white to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19160
Product name: EPZ020411
Purity: ≥98%
Packaging: 1mg
Price: $47
Updated: 2024/03/01

Cayman Chemical

Product number: 19160
Product name: EPZ020411
Purity: ≥98%
Packaging: 5mg
Price: $206
Updated: 2024/03/01

Cayman Chemical

Product number: 19160
Product name: EPZ020411
Purity: ≥98%
Packaging: 10mg
Price: $360
Updated: 2024/03/01

Cayman Chemical

Product number: 19160
Product name: EPZ020411
Purity: ≥98%
Packaging: 25mg
Price: $788
Updated: 2024/03/01

ApexBio Technology

Product number: B6088
Product name: EPZ020411
Packaging: 50mg
Price: $2048
Updated: 2021/12/16

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EPZ020411 Chemical Properties,Usage,Production

Biological Activity

epz020411 is an inhibitor of prmt6.prmt6, a member of the protein arginine methyltransferasefamily, comprises 45 enzymes. the post-translational modifications of prmt6 are important regulators of rna processing, transcriptional regulation, and signal transduction.

in vitro

in biochemical assays, epz020411 was found to be over 100-fold selective for prmt6/8/1 compared to other histone methyltransferases, such as prmt3, prmt4, prmt5 and prmt7. in addition, epz020411 treatment led to a dose-dependent decrease in h3r2 methylation, while treatment with its prmt6-inactive analog did not generate an ic50 at concentrations up to 20 μm [1].

in vivo

animal study found that male sd rats i.v. administered a single dose of epz020411 at 1 mg/kg showed a moderate clearance of 19.7 ml/min/kg, with a volume of distribution at steady state of 11.1 l/kg, and a mean terminal half-life of 8.54 h. following 5 mg/kg s.c. dosing, a good bioavailability of 65.6 was observed, resulting in epz020411 unbound concentration remaining over the prmt6 ic50 for more than 12 h [1].

IC 50

10 nm

References

[1] mitchell lh, et al. aryl pyrazoles as potent inhibitors of arginine methyltransferases: identification of the first prmt6 toolcompound. acs med chem lett. 2015 apr 6;6(6):655-659.

EPZ020411 Preparation Products And Raw materials

Raw materials

Preparation Products

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EPZ020411 Suppliers

China 56 United States 7 Global 63

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
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InvivoChem

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Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
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Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
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TargetMol Chemicals Inc.

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Email: support@targetmol.com
Country: United States
ProdList: 38631
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Aladdin Scientific

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Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
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ApexBio Technology

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Country: United States
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Cayman Chemical Company

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Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
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1700663-41-7, EPZ020411Related Search:

Trimethylamine hydrochloride Pyridine hydrochloride Dimethylamine hydrochloride Cysteamine hydrochloride

EPZ020411

N1,N2-dimethyl-N1-((3-(4-((1r,3r)-3-(2-(tetrahydro-2H-pyran-4-yl)ethoxy)cyclobutoxy)phenyl)-1H-pyrazol-4-yl)methyl)ethane-1,2-diamine

EPZ020411 HCl

EPZ020411 2HCl

EPZ 020411;EPZ-020411

CS-2262

1,2-Ethanediamine, N1,N2-dimethyl-N1-[[3-[4-[[trans-3-[2-(tetrahydro-2H-pyran-4-yl)ethoxy]cyclobutyl]oxy]phenyl]-1H-pyrazol-4-yl]methyl]-

1700663-41-7