Mal-PEG2-acid

ChemicalBook > CAS DataBase List > Mal-PEG2-acid

Product Name: Mal-PEG2-acid
CAS No.: 1374666-32-6
Chemical Name: Mal-PEG2-acid
Synonyms: Mal-PEG2-acid;Mal-PEG2-C2-COOH;Mal-NH-PEG2-acid;Mal-PEG2-CH2CH2COOH;Maleimide-PEG2-CH2CH2COOH;α-Maleimidyl-ω-propionyloxy poly(ethylene glycol);3-[2-[2-(2,5-dioxopyrrol-1-yl)ethoxy]ethoxy]propanoic acid;3-[2-[2-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]propanoic acid;3-[2-[2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethoxy]propanoic Acid;Propanoic acid, 3-[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]-
CBNumber: CB13062529
Molecular Formula: C11H15NO6
Formula Weight: 257.24
MOL File: 1374666-32-6.mol

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Mal-PEG2-acid Property

Boiling point:: 455.7±35.0 °C(Predicted)
Density: 1.329±0.06 g/cm3(Predicted)
pka: 4.27±0.10(Predicted)
form: powder to crystal
color: White to Light yellow
CAS DataBase Reference: 1374666-32-6

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Safety

HS Code: 2942000090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M3203
Product name: Mal-PEG2-acid
Packaging: 250MG
Price: $93
Updated: 2024/03/01

TCI Chemical

Product number: M3203
Product name: Mal-PEG2-acid
Packaging: 1G
Price: $294
Updated: 2024/03/01

TRC

Product number: M158208
Product name: Mal-PEG2-acid
Packaging: 5mg
Price: $65
Updated: 2021/12/16

TRC

Product number: M158208
Product name: Mal-PEG2-acid
Packaging: 10mg
Price: $90
Updated: 2021/12/16

TRC

Product number: M158208
Product name: Mal-PEG2-acid
Packaging: 50mg
Price: $330
Updated: 2021/12/16

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Mal-PEG2-acid Chemical Properties,Usage,Production

Description

Mal-PEG2-acid is a PEG linker containing a maleimide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Biological Activity

Mal-PEG2-acid is a non-cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs). It can bind to Tubulysin (HY-128914) and its cytotoxic derivatives activity. It can also be used as a PROTAC linker for PROTAC synthesis.

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Non-cleavable

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PEGs

Mal-PEG2-acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Mal-PEG2-acid manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Mal-PEG2-acid 1374666-32-6
Price: US $0.00/g
Min. Order: 5g
Purity: >98.00%
Supply Ability: 5g
Release date: 2024-03-27

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Mal-PEG2-acid

Maleimide-PEG2-CH2CH2COOH

Mal-PEG2-CH2CH2COOH

Mal-NH-PEG2-acid

3-[2-[2-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]propanoic acid

α-Maleimidyl-ω-propionyloxy poly(ethylene glycol)

Propanoic acid, 3-[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]-

3-[2-[2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethoxy]propanoic Acid

Mal-PEG2-CH2CH2COOH/Propanoic acid, 3-[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]-

Mal-PEG2-C2-COOH

3-[2-[2-(2,5-dioxopyrrol-1-yl)ethoxy]ethoxy]propanoic acid

1374666-32-6

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