ChemicalBook > CAS DataBase List > Mal-PEG2-acid

Mal-PEG2-acid

Product Name
Mal-PEG2-acid
CAS No.
1374666-32-6
Chemical Name
Mal-PEG2-acid
Synonyms
Mal-PEG2-acid;Mal-PEG2-C2-COOH;Mal-NH-PEG2-acid;Mal-PEG2-CH2CH2COOH;Maleimide-PEG2-CH2CH2COOH;α-Maleimidyl-ω-propionyloxy poly(ethylene glycol);3-[2-[2-(2,5-dioxopyrrol-1-yl)ethoxy]ethoxy]propanoic acid;3-[2-[2-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]propanoic acid;3-[2-[2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethoxy]propanoic Acid;Propanoic acid, 3-[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]-
CBNumber
CB13062529
Molecular Formula
C11H15NO6
Formula Weight
257.24
MOL File
1374666-32-6.mol
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Mal-PEG2-acid Property

Boiling point:
455.7±35.0 °C(Predicted)
Density 
1.329±0.06 g/cm3(Predicted)
pka
4.27±0.10(Predicted)
form 
powder to crystal
color 
White to Light yellow
CAS DataBase Reference
1374666-32-6
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Safety

HS Code 
2942000090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
M3203
Product name
Mal-PEG2-acid
Packaging
250MG
Price
$93
Updated
2024/03/01
TCI Chemical
Product number
M3203
Product name
Mal-PEG2-acid
Packaging
1G
Price
$294
Updated
2024/03/01
TRC
Product number
M158208
Product name
Mal-PEG2-acid
Packaging
5mg
Price
$65
Updated
2021/12/16
TRC
Product number
M158208
Product name
Mal-PEG2-acid
Packaging
10mg
Price
$90
Updated
2021/12/16
TRC
Product number
M158208
Product name
Mal-PEG2-acid
Packaging
50mg
Price
$330
Updated
2021/12/16
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Mal-PEG2-acid Chemical Properties,Usage,Production

Description

Mal-PEG2-acid is a PEG linker containing a maleimide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Biological Activity

Mal-PEG2-acid is a non-cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs). It can bind to Tubulysin (HY-128914) and its cytotoxic derivatives activity. It can also be used as a PROTAC linker for PROTAC synthesis.

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Non-cleavable

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PEGs

Mal-PEG2-acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Mal-PEG2-acid Suppliers

Americas 1 China 66 Europe 1 India 1 Japan 1 United Kingdom 1 United States 8 Global 79
Biomatrik (Jiaxing) Inc.
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View Lastest Price from Mal-PEG2-acid manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
Mal-PEG2-acid 1374666-32-6
Price
US $0.00/g
Min. Order
5g
Purity
>98.00%
Supply Ability
5g
Release date
2024-03-27

1374666-32-6, Mal-PEG2-acidRelated Search:

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  • Mal-PEG2-acid
  • Maleimide-PEG2-CH2CH2COOH
  • Mal-PEG2-CH2CH2COOH
  • Mal-NH-PEG2-acid
  • 3-[2-[2-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]propanoic acid
  • α-Maleimidyl-ω-propionyloxy poly(ethylene glycol)
  • Propanoic acid, 3-[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]-
  • 3-[2-[2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethoxy]propanoic Acid
  • Mal-PEG2-CH2CH2COOH/Propanoic acid, 3-[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]-
  • Mal-PEG2-C2-COOH
  • 3-[2-[2-(2,5-dioxopyrrol-1-yl)ethoxy]ethoxy]propanoic acid
  • 1374666-32-6
  • peg