Mal-PEG2-acid
- Product Name
- Mal-PEG2-acid
- CAS No.
- 1374666-32-6
- Chemical Name
- Mal-PEG2-acid
- Synonyms
- Mal-PEG2-acid;Mal-PEG2-C2-COOH;Mal-NH-PEG2-acid;Mal-PEG2-CH2CH2COOH;Maleimide-PEG2-CH2CH2COOH;α-Maleimidyl-ω-propionyloxy poly(ethylene glycol);3-[2-[2-(2,5-dioxopyrrol-1-yl)ethoxy]ethoxy]propanoic acid;3-[2-[2-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]propanoic acid;3-[2-[2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethoxy]propanoic Acid;Propanoic acid, 3-[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]-
- CBNumber
- CB13062529
- Molecular Formula
- C11H15NO6
- Formula Weight
- 257.24
- MOL File
- 1374666-32-6.mol
Mal-PEG2-acid Property
- Boiling point:
- 455.7±35.0 °C(Predicted)
- Density
- 1.329±0.06 g/cm3(Predicted)
- pka
- 4.27±0.10(Predicted)
- form
- powder to crystal
- color
- White to Light yellow
- CAS DataBase Reference
- 1374666-32-6
Safety
- HS Code
- 2942000090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- M3203
- Product name
- Mal-PEG2-acid
- Packaging
- 250MG
- Price
- $93
- Updated
- 2024/03/01
- Product number
- M3203
- Product name
- Mal-PEG2-acid
- Packaging
- 1G
- Price
- $294
- Updated
- 2024/03/01
- Product number
- M158208
- Product name
- Mal-PEG2-acid
- Packaging
- 5mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- M158208
- Product name
- Mal-PEG2-acid
- Packaging
- 10mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- M158208
- Product name
- Mal-PEG2-acid
- Packaging
- 50mg
- Price
- $330
- Updated
- 2021/12/16
Mal-PEG2-acid Chemical Properties,Usage,Production
Description
Mal-PEG2-acid is a PEG linker containing a maleimide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Biological Activity
Mal-PEG2-acid is a non-cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs). It can bind to Tubulysin (HY-128914) and its cytotoxic derivatives activity. It can also be used as a PROTAC linker for PROTAC synthesis.
in vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| Non-cleavable < span> | PEGs
|
Mal-PEG2-acid Preparation Products And Raw materials
Raw materials
Preparation Products
Mal-PEG2-acid Suppliers
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
- Country
- Europe
- ProdList
- 23680
- Advantage
- 75
View Lastest Price from Mal-PEG2-acid manufacturers
- Product
- Mal-PEG2-acid 1374666-32-6
- Price
- US $0.00/g
- Min. Order
- 5g
- Purity
- >98.00%
- Supply Ability
- 5g
- Release date
- 2024-03-27