CCF-642
- Product Name
- CCF-642
- CAS No.
- 346640-08-2
- Chemical Name
- CCF-642
- Synonyms
- CCF-642;AC1LYELL;CCF 642, ≥98%;CCF 642;CCF-642;CCF642 >=98% (HPLC);CCF 642;CCF-642;AC1LYELL;3-(4-Methoxyphenyl)-5-[(5-nitro-2-thienyl)methylene]-2-thioxo-4-thiazolidinone;4-Thiazolidinone, 3-(4-methoxyphenyl)-5-[(5-nitro-2-thienyl)methylene]-2-thioxo-;3-(4-Methoxyphenyl)-5-((5-nitrothiophen-2-yl)methylene)-2-thioxothiazolidin-4-one;calcium,Inhibitor,PDI,CCF642,apoptosis,isomerases,disulfide,myeloma,CCF-642,protein,multiple,release,stress,inhibit,anti-multiple,CCF 642
- CBNumber
- CB13133223
- Molecular Formula
- C15H10N2O4S3
- Formula Weight
- 378.45
- MOL File
- 346640-08-2.mol
CCF-642 Property
- Boiling point:
- 567.3±60.0 °C(Predicted)
- Density
- 1.60±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO:14.4(Max Conc. mg/mL);38.05(Max Conc. mM)
- form
- powder
- pka
- -0.70±0.20(Predicted)
- color
- yellow to orange
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML1827
- Product name
- CCF642
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $114
- Updated
- 2024/03/01
- Product number
- SML1827
- Product name
- CCF642
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $464
- Updated
- 2024/03/01
- Product number
- 27054
- Product name
- CCF-642
- Packaging
- 5mg
- Price
- $100
- Updated
- 2024/03/01
- Product number
- 27054
- Product name
- CCF-642
- Packaging
- 25mg
- Price
- $343
- Updated
- 2024/03/01
- Product number
- 27054
- Product name
- CCF-642
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
CCF-642 Chemical Properties,Usage,Production
Uses
CCF642 has been used as a protein disulfide isomerase (PDI) inhibitor to study its ability to reduce the expression of endoplasmic reticulum (ER) stress markers and neuroinflammation in the hippocampus of experimental autoimmune encephalomyelitis (EAE) mice.
Biochem/physiol Actions
CCF642 is a cell-permeable protein disulfide isomerase (PDI) inhibitor that exhibits 100-fold higher potency than PACMA 31 (by di-E-GSSG assay) via an alternative mode of action that most likely involves PDI active-site CGHCK motifs instead of cysteine known to be targeted by PACMA 31. CCF642 displays anti-multiple myeloma (MM) activity both in cultures in vitro (IC50 <1 μM against murine 5TGM1 and nine human MM lines) and in mice in vivo (10 mg/kg, 3X i.p. per wk) without apparent adverse effects to the animals or being cytotoxic to normal bone marrow (NLBM) cells even at concentrations as high as 6.75 μM. Consistent with PDI′s role in ER protein folding process, CCF642 treatment causes acute ER stress accompanied by apoptosis-inducing calcium release in MM cells.
CCF-642 Preparation Products And Raw materials
Raw materials
Preparation Products
CCF-642 Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77