2-CHLORO-3-(TRIFLUOROMETHYL)BENZALDEHYDE
Uses- Product Name
- 2-CHLORO-3-(TRIFLUOROMETHYL)BENZALDEHYDE
- CAS No.
- 93118-03-7
- Chemical Name
- 2-CHLORO-3-(TRIFLUOROMETHYL)BENZALDEHYDE
- Synonyms
- 2-Fluoro-4-hydroxybenzonitrile;TIMTEC-BB SBB003469;3-Chloro-6-fluoroacetophenone;2-Choro-3-(trifluoroMethyl)benzaldehyde;2-CHLORO-3-(TRIFLUOROMETHYL)BENZALDEHYDE;Benzaldehyde, 2-chloro-3-(trifluoromethyl)-;2-Chloro-3-(trifluoromethyl)benzaldehyde98%;2-Chloro-3-(trifluoromethyl)benzaldehyde 98%;2-CHLORO-3-(TRIFLUOROMETHYL)BENZALDEHYDE ISO 9001：2015 REACH
- CBNumber
- CB1314368
- Molecular Formula
- C8H4ClF3O
- Formula Weight
- 208.57
- MOL File
- 93118-03-7.mol
2-CHLORO-3-(TRIFLUOROMETHYL)BENZALDEHYDE Property
- Melting point:
- 37-43 °C (lit.)
- Boiling point:
- 216.6±35.0 °C(Predicted)
- Density
- 1.423±0.06 g/cm3(Predicted)
- Flash point:
- >230 °F
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- Crystals or Powder
- color
- White to off-white
- Sensitive
- Air Sensitive
- BRN
- 3543607
- CAS DataBase Reference
- 93118-03-7(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 481912
- Product name
- 2-Chloro-3-(trifluoromethyl)benzaldehyde
- Purity
- 96%
- Packaging
- 1g
- Price
- $33
- Updated
- 2023/01/07
- Product number
- C596550
- Product name
- 2-Chloro-3-(trifluoromethyl)benzaldehyde
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FC105432
- Product name
- 2-chloro-3-(trifluoromethyl)benzaldehyde
- Packaging
- 1g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- FC105432
- Product name
- 2-chloro-3-(trifluoromethyl)benzaldehyde
- Packaging
- 2g
- Price
- $140
- Updated
- 2021/12/16
- Product number
- 007804
- Product name
- 2-Chloro-3-(trifluoromethyl)benzaldehyde
- Packaging
- 5g
- Price
- $66
- Updated
- 2021/12/16
2-CHLORO-3-(TRIFLUOROMETHYL)BENZALDEHYDE Chemical Properties,Usage,Production
Uses
2-Chloro-3-(trifluoromethyl)benzaldehyde can be used as an organic synthesis intermediate, which can be prepared by reacting 2-trifluoromethyl-chlorobenzene with n-butyllithium. It can be used to prepare the pharmaceutical intermediate (2-chloro-3-trifluoromethylbenzyl)cyclopropylamine.
General Description
4-Chloro-3-(trifluoromethyl)benzaldehyde is a substituted benzaldehyde.
Synthesis
68-12-2
93118-03-7
The general procedure for the synthesis of 2-chloro-3-(trifluoromethyl)benzaldehyde from N,N-dimethylformamide was as follows: n-butyllithium (1.6 M hexane solution, 173 mL, 277 mmol) was added dropwise to the reaction system at -70 °C. Subsequently, a tetrahydrofuran (500 mL) solution of 2-trifluoromethylchlorobenzene (50.0 g, 277 mmol) was slowly added. The reaction temperature was maintained at -70°C and the reaction mixture was stirred for 2 hours. Then, a tetrahydrofuran (100 mL) solution of N,N-dimethylformamide (21.3 mL, 277 mmol) was added. The reaction mixture was gradually warmed to room temperature and stirred overnight. Upon completion of the reaction, the reaction was quenched by the addition of water (200 mL) and the mixture was extracted with ether (2 x 200 mL). The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to remove the solvent. The residue was purified by fast column chromatography (eluent: heptane/ethyl acetate=20:1) to afford the target product 2-chloro-3-(trifluoromethyl)benzaldehyde (37.4 g, 65% yield). Analyzed by liquid chromatography-mass spectrometry: retention time t R = 0.96 min.
References
[1] Patent: WO2006/21402, 2006, A1. Location in patent: Page/Page column 42
2-CHLORO-3-(TRIFLUOROMETHYL)BENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-CHLORO-3-(TRIFLUOROMETHYL)BENZALDEHYDE manufacturers
- Product
- 2-CHLORO-3-(TRIFLUOROMETHYL)BENZALDEHYDE 93118-03-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-12-04
- Product
- 2-CHLORO-3-(TRIFLUOROMETHYL)BENZALDEHYDE 93118-03-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- 2-CHLORO-3-(TRIFLUOROMETHYL)BENZALDEHYDE 93118-03-7
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2018-12-17