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Rbin-1

Product Name
Rbin-1
CAS No.
328023-11-6
Chemical Name
Rbin-1
Synonyms
Rbin-1;CS-2565;Ribozinoindole1;Ribozinoindole-1;Ribozinoindole 1;Rbin-1 - Ribozinoindole-1;3-((2-Methylallyl)thio)-5H-[1,2,4]triazino[5,6-b]indole;3-(2-methylprop-2-enylsulfanyl)-5H-[1,2,4]triazino[5,6-b]indole;5H-1,2,4-Triazino[5,6-b]indole, 3-[(2-methyl-2-propen-1-yl)thio]-;RBIN 1;RIBOZINOINDOLE 1;RBIN1;RIBOZINOINDOLE-1;RBIN-1;RIBOZINOINDOLE1
CBNumber
CB13147547
Molecular Formula
C13H12N4S
Formula Weight
256.33
MOL File
328023-11-6.mol
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Rbin-1 Property

Boiling point:
479.6±47.0 °C(Predicted)
Density 
1.34±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
Soluble in DMSO (up to at least 25 mg/ml)
pka
10.34±0.50(Predicted)
form 
solid
color 
Pale yellow
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
20745
Product name
Rbin-1
Purity
≥98%
Packaging
1mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
20745
Product name
Rbin-1
Purity
≥98%
Packaging
5mg
Price
$388
Updated
2024/03/01
TRC
Product number
R128300
Product name
3-[(2-Methyl-2-propen-1-yl)thio]-5H-1,2,4-triazino[5,6-b]indole
Packaging
1mg
Price
$105
Updated
2021/12/16
ChemScene
Product number
CS-6068
Product name
Rbin-1
Purity
99.91%
Packaging
1mg
Price
$110
Updated
2021/12/16
Axon Medchem
Product number
Axon2663
Product name
Rbin-1-Ribozinoindole-1
Purity
99%
Packaging
10mg
Price
$137.5
Updated
2021/12/16
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Rbin-1 Chemical Properties,Usage,Production

Description

Rbin-1 is a triazinoindole inhibitor of midasin (mdn1), an essential protein for eukaryotic ribosome biogenesis. It inhibits the growth of fission yeast strains in vitro (GI50 = 136 nM) and inhibits mdn1 ATPase activity by approximately 40% when used at a concentration of 1 μM. Rbin-1 inhibits pre-rRNA processing and nuclear export of the pre-60S ribosome subunit in mdn1-ts, but not mdn1-F1093L mutant, S. pombe cells. It also decreases ribosome assembly protein 4 (Rsa4) levels in Rix1 particles, a ribosome assembly intermediate, Rix1-bound Ytm1 levels, and Rix7 and Ppp1 levels in the nucleolar pre-60S particle Nsa1 in mdn1-ts fission yeast cells.

Uses

3-[(2-Methyl-2-propen-1-yl)thio]-5H-1,2,4-triazino[5,6-b]indole is a triazinoindole derivative that inhibits eukaryotic ribosome biogenesis (1). It is also an ATPase inhibitor (1).

Definition

ChEBI: Ribozinoindole-1 is a triazinoindole that is 5H-[1,2,4]triazino[5,6-b]indole which is substituted at position 3 by a (2-methylprop-2-en-1-yl)thio group. A potent inhibitor of midasin which is an essential protein for eukaryotic ribosome biogenesis. It is a triazinoindole and an organic sulfide.

References

1) Kawashime?et al.?(2016),?Potent, Reversible, and Specific Chemical Inhibitors of Eukaryotic Ribosome Biogenesis; Cell?167?512

Rbin-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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Rbin-1 Suppliers

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328023-11-6, Rbin-1Related Search:

Tris(2-carboxyethyl)phosphine hydrochloride SGC707 BAFILOMYCIN A1 CTPB

  • Rbin-1
  • 3-(2-methylprop-2-enylsulfanyl)-5H-[1,2,4]triazino[5,6-b]indole
  • Rbin-1 - Ribozinoindole-1
  • RBIN 1;RIBOZINOINDOLE 1;RBIN1;RIBOZINOINDOLE-1;RBIN-1;RIBOZINOINDOLE1
  • Ribozinoindole 1
  • Ribozinoindole1
  • Ribozinoindole-1
  • CS-2565
  • 5H-1,2,4-Triazino[5,6-b]indole, 3-[(2-methyl-2-propen-1-yl)thio]-
  • 3-((2-Methylallyl)thio)-5H-[1,2,4]triazino[5,6-b]indole
  • Phosphatase,inhibit,Rbin-1,Rbin1,Inhibitor,Ribozinoindole 1,Ribozinoindole1,Rbin 1
  • 328023-11-6