Rbin-1
- Product Name
- Rbin-1
- CAS No.
- 328023-11-6
- Chemical Name
- Rbin-1
- Synonyms
- Rbin-1;CS-2565;Ribozinoindole1;Ribozinoindole-1;Ribozinoindole 1;Rbin-1 - Ribozinoindole-1;3-((2-Methylallyl)thio)-5H-[1,2,4]triazino[5,6-b]indole;3-(2-methylprop-2-enylsulfanyl)-5H-[1,2,4]triazino[5,6-b]indole;5H-1,2,4-Triazino[5,6-b]indole, 3-[(2-methyl-2-propen-1-yl)thio]-;RBIN 1;RIBOZINOINDOLE 1;RBIN1;RIBOZINOINDOLE-1;RBIN-1;RIBOZINOINDOLE1
- CBNumber
- CB13147547
- Molecular Formula
- C13H12N4S
- Formula Weight
- 256.33
- MOL File
- 328023-11-6.mol
Rbin-1 Property
- Boiling point:
- 479.6±47.0 °C(Predicted)
- Density
- 1.34±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- Soluble in DMSO (up to at least 25 mg/ml)
- pka
- 10.34±0.50(Predicted)
- form
- solid
- color
- Pale yellow
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 20745
- Product name
- Rbin-1
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 20745
- Product name
- Rbin-1
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $388
- Updated
- 2024/03/01
- Product number
- R128300
- Product name
- 3-[(2-Methyl-2-propen-1-yl)thio]-5H-1,2,4-triazino[5,6-b]indole
- Packaging
- 1mg
- Price
- $105
- Updated
- 2021/12/16
- Product number
- CS-6068
- Product name
- Rbin-1
- Purity
- 99.91%
- Packaging
- 1mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- Axon2663
- Product name
- Rbin-1-Ribozinoindole-1
- Purity
- 99%
- Packaging
- 10mg
- Price
- $137.5
- Updated
- 2021/12/16
Rbin-1 Chemical Properties,Usage,Production
Description
Rbin-1 is a triazinoindole inhibitor of midasin (mdn1), an essential protein for eukaryotic ribosome biogenesis. It inhibits the growth of fission yeast strains in vitro (GI50 = 136 nM) and inhibits mdn1 ATPase activity by approximately 40% when used at a concentration of 1 μM. Rbin-1 inhibits pre-rRNA processing and nuclear export of the pre-60S ribosome subunit in mdn1-ts, but not mdn1-F1093L mutant, S. pombe cells. It also decreases ribosome assembly protein 4 (Rsa4) levels in Rix1 particles, a ribosome assembly intermediate, Rix1-bound Ytm1 levels, and Rix7 and Ppp1 levels in the nucleolar pre-60S particle Nsa1 in mdn1-ts fission yeast cells.
Uses
3-[(2-Methyl-2-propen-1-yl)thio]-5H-1,2,4-triazino[5,6-b]indole is a triazinoindole derivative that inhibits eukaryotic ribosome biogenesis (1). It is also an ATPase inhibitor (1).
Definition
ChEBI: Ribozinoindole-1 is a triazinoindole that is 5H-[1,2,4]triazino[5,6-b]indole which is substituted at position 3 by a (2-methylprop-2-en-1-yl)thio group. A potent inhibitor of midasin which is an essential protein for eukaryotic ribosome biogenesis. It is a triazinoindole and an organic sulfide.
References
1) Kawashime?et al.?(2016),?Potent, Reversible, and Specific Chemical Inhibitors of Eukaryotic Ribosome Biogenesis; Cell?167?512