IPI-549

Product Name: IPI-549
CAS No.: 1693758-51-8
Chemical Name: IPI-549
Synonyms: Eganelisib;IPI-549;CS-2414;IPI-549(IPI549);IPI549 (Eganelisib);Eganelisib (IPI-549);IPI-549; IPI 549; IPI549.;IPI-549, 98%, a potent and selective PI3Kγ Inhibitor;(S)-2-amino-N-(1-(8-((1-methyl-1H-pyrazol-4-yl)ethynyl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-Amino-N-[(1S)-1-[1,2-dihydro-8-[2-(1-methyl-1H-pyrazol-4-yl)ethynyl]-1-oxo-2-phenyl-3-isoquinolinyl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
CBNumber: CB13147769
Molecular Formula: C30H24N8O2
Formula Weight: 528.56
MOL File: 1693758-51-8.mol

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IPI-549 Property

Density: 1.37±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (up to at least 25 mg/ml)
form: solid
pka: 10.81±0.46(Predicted)
color: Pale yellow
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
CAS DataBase Reference: 1693758-51-8

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 26416
Product name: IPI-549
Packaging: 5mg
Price: $120
Updated: 2024/03/01

Cayman Chemical

Product number: 26416
Product name: IPI-549
Packaging: 25mg
Price: $384
Updated: 2024/03/01

Cayman Chemical

Product number: 26416
Product name: IPI-549
Packaging: 1mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 26416
Product name: IPI-549
Packaging: 10mg
Price: $223
Updated: 2024/03/01

TRC

Product number: I739410
Product name: IPI549
Packaging: 5mg
Price: $95
Updated: 2021/12/16

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IPI-549 Chemical Properties,Usage,Production

Description

IPI-549 (1693758-51-8) is a potent and highly selective inhibitor of PI3K-γ in both biochemical (IC50?= 16 nM) and cellular (IC50?= 12.2 nM) assays.1?Macrophage PI3K-γ has been found to be a critical switch between immune stimulation and suppression.2?IPI-549 has been used to reshape tumor immune microenvironments and promote cytotoxic T-cell-mediated tumor regression. Resistance to immune checkpoint blockade in 4T1 and B16-GMCSF tumors was overcome when anti-PD-1 or anti-CTLA4 therapies were combined with PI3K-γ inhibition via IPI-549.3?IPI-549 mono-treatment also resulted in tumor growth inhibition in several cancer cell lines.3?IPI-549 has also been shown to modulate P-glycoprotein-mediated multidrug resistance.4

Uses

IPI-549 is a selective phosphoinositide-3-kinase (PI3Kγ) Inhibitor. PI3Kγ inhibitors can be used to develop potential treatment for inflammatory and autoimmune diseases.

References

1) Evans?et al.?(2016)?Discovery of a Selective Phosphoinositide-3-Kinase (PI3K)-gamma Inhibitor (IPI-549) as an Immuno-Oncology Clinical Candidate; ACS Med. Chem. Lett.?7?862 2) Kaneda?et al.?(2016)?PI3Kγ is a molecular switch that controls immune suppression; Nature?539?437 3) De Henau?et al.?(2016);?Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells; Nature?539?443 4) De Vera?et al. (2019);?Immuno-oncology agent IPI-549 is a modulator of P-glycoprotein (P-gp, MDR1, ABCB1)-mediated multidrug resistance (MDR) in cancer: In vitro and in vivo; Cancer Letters?442?91

IPI-549 Preparation Products And Raw materials

Raw materials

Preparation Products

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IPI-549 Suppliers

China 94 United States 11 Global 105

Shanghai YuanQi Biotechnology Co., Ltd.

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WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

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Chembest Research Laboratories Limited

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Nanjing Chemlin Chemical Co., Ltd

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DKMbiochem.Co. Ltd

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Finetech Industry Limited

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1693758-51-8, IPI-549Related Search:

S-Trityl-L-cysteine ZM 336372 LFM-A13 CL 82198 HYDROCHLORIDE

IPI-549

(S)-2-amino-N-(1-(8-((1-methyl-1H-pyrazol-4-yl)ethynyl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

IPI-549(IPI549)

IPI-549, 98%, a potent and selective PI3Kγ Inhibitor

CS-2414

IPI-549; IPI 549; IPI549.

Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[(1S)-1-[1,2-dihydro-8-[2-(1-methyl-1H-pyrazol-4-yl)ethynyl]-1-oxo-2-phenyl-3-isoquinolinyl]ethyl]-

IPI549 (Eganelisib)

Eganelisib

Eganelisib (IPI-549)

2-Amino-N-[(1S)-1-[1,2-dihydro-8-[2-(1-methyl-1H-pyrazol-4-yl)ethynyl]-1-oxo-2-phenyl-3-isoquinolinyl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide

1693758-51-8

API

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