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Tetracosactide acetate

Product Name
Tetracosactide acetate
CAS No.
16960-16-0
Chemical Name
Tetracosactide acetate
Synonyms
TETRACOSACTIDE;synacthen;cortrosyn;tetracosactrin;Tetracosactide CRS;Tetracosactide acetate;SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-GLY-LYS-LYS-ARG-ARG-PRO-VAL-LYS-VAL-TYR-PRO;acth-z;C06926;ba30920
CBNumber
CB1325409
Molecular Formula
C136H210N40O31S
Formula Weight
2933.44
MOL File
16960-16-0.mol
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Tetracosactide acetate Property

Density 
1.47±0.1 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
Sparingly soluble in water.
form 
Solid
color 
White to off-white
Water Solubility 
Soluble in water
Sequence
H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH
Stability:
Hygroscopic
InChI
InChI=1S/C136H210N40O31S/c1-75(2)109(127(200)154-71-106(181)156-88(31-13-17-52-137)114(187)158-89(32-14-18-53-138)115(188)159-91(35-21-56-149-134(142)143)116(189)164-96(37-23-58-151-136(146)147)131(204)175-60-25-39-104(175)126(199)173-111(77(5)6)128(201)163-90(33-15-19-54-139)120(193)171-110(76(3)4)129(202)169-101(65-80-43-47-84(180)48-44-80)132(205)176-61-26-40-105(176)133(206)207)172-125(198)103-38-24-59-174(103)130(203)95(34-16-20-55-140)157-107(182)70-153-113(186)99(66-81-68-152-87-30-12-11-29-85(81)87)167-117(190)92(36-22-57-150-135(144)145)160-121(194)98(63-78-27-9-8-10-28-78)166-123(196)100(67-82-69-148-74-155-82)168-118(191)93(49-50-108(183)184)161-119(192)94(51-62-208-7)162-124(197)102(73-178)170-122(195)97(165-112(185)86(141)72-177)64-79-41-45-83(179)46-42-79/h8-12,27-30,41-48,68-69,74-77,86,88-105,109-111,152,177-180H,13-26,31-40,49-67,70-73,137-141H2,1-7H3,(H,148,155)(H,153,186)(H,154,200)(H,156,181)(H,157,182)(H,158,187)(H,159,188)(H,160,194)(H,161,192)(H,162,197)(H,163,201)(H,164,189)(H,165,185)(H,166,196)(H,167,190)(H,168,191)(H,169,202)(H,170,195)(H,171,193)(H,172,198)(H,173,199)(H,183,184)(H,206,207)(H4,142,143,149)(H4,144,145,150)(H4,146,147,151)/t86-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,109-,110-,111-/m0/s1
InChIKey
ZOEFCCMDUURGSE-SQKVDDBVSA-N
SMILES
C(N[C@@H](CC1C=CC(O)=CC=1)C(N[C@@H](CO)C(N[C@@H](CCSC)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC1N=CNC=1)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1C2C(=CC=CC=2)NC=1)C(NCC(N[C@@H](CCCCN)C(N1CCC[C@H]1C(N[C@@H](C(C)C)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N1CCC[C@H]1C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](CC1C=CC(O)=CC=1)C(N1CCC[C@H]1C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)([C@H](CO)N)=O
CAS DataBase Reference
16960-16-0(CAS DataBase Reference)
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Safety

WGK Germany 
3
RTECS 
GM7915000
HS Code 
2937220000
Hazardous Substances Data
16960-16-0(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H317May cause an allergic skin reaction

H332Harmful if inhaled

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P285In case of inadequate ventilation wear respiratory protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A0298
Product name
Adrenocorticotropic Hormone Fragment 1-24 human, rat
Purity
≥97% (HPLC)
Packaging
250μg
Price
$101
Updated
2024/03/01
Sigma-Aldrich
Product number
A0298
Product name
Adrenocorticotropic Hormone Fragment 1-24 human, rat
Purity
≥97% (HPLC)
Packaging
1mg
Price
$292
Updated
2024/03/01
Sigma-Aldrich
Product number
1150115
Product name
Cosyntropin acetate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
1.72MG
Price
$612
Updated
2024/03/01
Sigma-Aldrich
Product number
1150115
Product name
Adrenocorticotropic Hormone Fragment 1-24 human, rat
Packaging
1.69mg
Price
$574
Updated
2022/05/15
Alfa Aesar
Product number
J66365
Product name
Adrenocorticotropic Hormone (1-24), human
Packaging
1mg
Price
$153
Updated
2023/06/20
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Tetracosactide acetate Chemical Properties,Usage,Production

Description

Cosyntropin (Tetracosactide acetate) is a synthetic polypeptide that consists of amino acid residues 1 through 24 of human ACTH, but that has the full biological activity of its parent. Because it is of synthetic origin, it is less allergenic than ACTH of natural origin. Cosyntropin is used as a diagnostic agent in the screening of patients suspected of having adrenocortical insufficiency. Normally, parenteral administration of cosyntropin acts rapidly on the adrenal cortex to effect release of plasma hydrocortisone; when performing the test, the hydrocortisone levels are compared to a control blood sample taken earlier.

Chemical Properties

White or yellow, amorphous powder.

Uses

Adrenocorticotropic Hormone (1-24), human is used in the treatment of West syndrome. It activates G proteins. It stimulates secretion of glucocorticoid steroid hormones from adrenal cortex cells. It also enhances transcription of mitochondrial genes.

Uses

Adrenocorticotropic Hormone Fragment 1-24 human, rat, has been used in corticosterone enzyme immunoassay and to induce color change in frogs.

Indications

Cosyntropin (Cortrosyn) is a polypeptide that consists solely of the first 24 amino acids of corticotropin. It appears to offer an advantage over the naturally occurring hormone in that it has a longer duration of action and lacks the antigenic portion of corticotropin. Although the short cosyntropin test is recognized as a valid screening test to assess adrenocortical insufficiency, the overnight metyrapone test or insulin hypoglycemia test may prove more sensitive.

Definition

ChEBI: A synthetic peptide that is identical to the 24-amino acid segment at the N-terminal of adrenocorticotropic hormone (corticotropin). A segment similar in all species, it contains the biological activity that stimulates production of cort costeroids in the adrenal cortex. It is used diagnostically to investigate adrenocortical insufficiency.

brand name

Cortrosyn (Amphastar).

General Description

Cosyntropin (Cortrosyn) is a syntheticpeptide containing the first 24 amino acids of natural corticotropin.Cosyntropin is used as a diagnostic agent to testfor adrenal cortical deficiency. Plasma hydrocortisone concentrationis determined before and 30 minutes after theadministration of 250 g of cosyntropin. Most normal responses result in an approximate doubling of the basalhydrocortisone concentration in 30 to 60 minutes. If the responseis not normal, adrenal insufficiency is indicated.Such adrenal insufficiency could be a result of either adrenalor pituitary malfunction, and further testing is requiredto distinguish between the two. Cosyntropin (250 μg infusedwithin 4–8 hours) or corticotropin (80–120 U/day for3–4 days) is administered. Patients with functional adrenaltissue should respond to this dosage. Patients who respondaccordingly are suspected of hypopituitarism, and the diagnosiscan be confirmed by other tests for pituitary function.Patients who have Addison disease, however, show little orno response.

Biological Activity

Tetracosactide Acetate (SR-TA) stimulates the release of corticosteroids such as cortisol from the adrenal gland. It is absorbed into a zinc phosphate complex, which ensures the sustained release of the active substance from the intramuscular injection site. SR-TA is currently used to manage ulcerative colitis, Crohn's disease, juvenile/adult rheumatoid arthritis, and osteoarthrosis[1].

Biochem/physiol Actions

Activates G proteins.

Side effects

Common side effects of Tetracosactide acetate may include: an allergic reaction (hives; difficult breathing; swelling of your face, lips, tongue, or throat); fast or slow heartbeats; increased blood pressure; rash; swelling in your hands or feet.

Veterinary Drugs and Treatments

Cosyntropin is used primarily as an alternative to ACTH to test for adrenocortical insufficiency (Addison’s), or hyperadrenocorticism, particularly in animals who have reacted immunologically to corticotropin in the past or if ACTH gel is unavailable.

References

[1] F. Iuliano, M. Rossi, Eleonora Iuliano. “Adding Slow Release Tetracosactide Acetate to Eltrombopag Improves Haematological Response in ITP Patients with Platelet-Count Fluctuation.” Blood (2018).

Tetracosactide acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Tetracosactide acetate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Tetracosactide Acetate 16960-16-0
Price
US $0.00/g
Min. Order
1g
Purity
98%min
Supply Ability
1000g
Release date
2023-01-12
hebei hongtan Biotechnology Co., Ltd
Product
Cosyntropin 16960-16-0
Price
US $30.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000kg
Release date
2024-03-20
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Tetracosactide acetate 16960-16-0
Price
US $500.00-300.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-23

16960-16-0, Tetracosactide acetateRelated Search:

Corticotropin Cortisone acetate BPP 9A Tolvaptan LHRH Ipamorelin Deslorelin Abarelix Teduglutide Semaglutide Teriparatide acetate Terlipressin acetate Teriparatideacetate Adrenocorticotropic hormone MET-GLU-HIS-PHE-ARG-TRP-GLY H-SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-NH2 PHE-PRO AC-LYS-PRO-VAL-NH2

  • L-SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-GLY-LYS-LYS-ARG-ARG-PRO-VAL-LYS-VAL-TYR-PRO
  • cosyntropin
  • H-SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-GLY-LYS-LYS-ARG-ARG PRO-VAL-LYS-VAL-TYR-PRO-OH TETRACOSACTIDE (HUMAN, BOVINE, MOUSE, OVINE, PORCINE, RABBIT, RAT)
  • H-SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-GLY-LYS-LYS-ARG-ARG-PRO-VAL-LYS-VAL-TYR-PRO-OH
  • SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-GLY-LYS-LYS-ARG-ARG-PRO-VAL-LYS-VAL-TYR-PRO HUMAN
  • SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-GLY-LYS-LYS-ARG-ARG-PRO-VAL-LYS-VAL-TYR-PRO
  • TETRACOSACTIDE
  • TETRACOSACTIDE (HUMAN)
  • SYSMEHFRWGKPVGKKRRPVKVYP
  • acth-alpha(1-24)
  • acthalpha(1-24)
  • actholain
  • acth-z
  • adrenocorticotropichormone1-24
  • adrenocorticotropin(1-24)
  • alpha(1-24)acth
  • alpha(1-24)-acth
  • alpha(1-24)-corticotropin
  • alpha(sup1-24)-corticotropin
  • ba30920
  • ba36716
  • beta(1-24)acth
  • beta(1-24)-acth
  • beta(1-24)-corticotropin
  • beta(1-24)-tetracosactide
  • beta(sup1-24)-corticotropin
  • beta-corticotrophin-(1-24)-tetracosapeptide
  • corticotropin-(1-24)
  • cortrophins
  • cortrosinta
  • cortrosyn
  • enylalanyl-l-arginyl-l-tryptophylglycyl-l-l///
  • l-proline,l-seryl-l-tyrosyl-l-seryl-l-methionyl-l-glutamyl-l-alpha-histidyl-ph
  • Tetracosactide, Cosyntropin, Tetracosactrin
  • Adrenocorticotropic hormone fragment 1-24 human (ACTH)
  • nuvacthendepot
  • porcineacth(1-24)
  • synacthen
  • synecthen
  • tetracosactid
  • tetracosactrin
  • tetracosapeptide
  • Fam-ACTH (1-24), human
  • α1-24-Adrenocorticotropic-d4 Hormone
  • α1-24-Adrenocorticotropic Hormone
  • Cosyntropin Acetate
  • 1-icosyl-8-methyl-8-azabicyclo[3.2.1]octan-3-ol
  • Tetracosactide(1-24)/ACTH (1-24) Acetate
  • Tetracosactide, Tetracosactida, Tetracosactidum
  • Adrenocorticotropic Hormone (ACTH) (1-24), human
  • Tetracosactide Acetae
  • Adrenocorticotropic hormone fragment 1-24 human (ACTH), ≥97% (HPLC)
  • ACTH(1-24)/Cosyntropin
  • Tetrocosactide(ACTH)
  • ADRENOCORTICOTROPIC HORMONE FRAGMENT1-24 HUMAN
  • adrenocorticotropic hormone fragment 1-24 human, rat
  • Tetracosactide acetate
  • ACTH (1-24), HUMAN