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Adenine hydrochloride

Product Name
Adenine hydrochloride
CAS No.
2922-28-3
Chemical Name
Adenine hydrochloride
Synonyms
ADENINE HCL;6-AMINOPURINE HCL;ADENINIUM CHLORIDE;TIMTEC-BB SBB003841;Adenine hydrocloride;ADENINE HYDROCHLORIDE;7H-adenine hydrochloride;ADENINE MONOHYDROCHLORIDE;Adenine hydrochloride ,98%;6-AMINOPURINE HYDROCHLORIDE
CBNumber
CB1334849
Molecular Formula
C5H6ClN5
Formula Weight
171.59
MOL File
2922-28-3.mol
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Adenine hydrochloride Property

Melting point:
~285 °C (dec.)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
H2O: 50 mg/mL
form 
powder
color 
White to Off-White
Merck 
14,152
BRN 
4009585
CAS DataBase Reference
2922-28-3(CAS DataBase Reference)
EPA Substance Registry System
1H-Purin-6-amine, monohydrochloride (2922-28-3)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
26-36-36/37/39-24/25
WGK Germany 
3
3-8
TSCA 
Yes
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P321Specific treatment (see … on this label).

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A8751
Product name
Adenine hydrochloride hydrate
Purity
≥99%
Packaging
1g
Price
$40.08
Updated
2024/03/01
Sigma-Aldrich
Product number
01840
Product name
Adenine monohydrochloride
Purity
≥99.0% (HPLC)
Packaging
25g
Price
$51
Updated
2024/03/01
TCI Chemical
Product number
A0150
Product name
Adenine Hydrochloride Hemihydrate
Purity
>98.0%(T)
Packaging
5g
Price
$27
Updated
2022/04/27
TCI Chemical
Product number
A0150
Product name
Adenine Hydrochloride Hemihydrate
Purity
>98.0%(T)
Packaging
25g
Price
$79
Updated
2022/04/27
Alfa Aesar
Product number
A17622
Product name
Adenine hydrochloride, 98+%, cont. up to ca 5% water
Packaging
5g
Price
$24.65
Updated
2024/03/01
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Adenine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

Adenine hydrochloride hydrate has been used:

  • As a component of FAD cell culture media
  • In maintaining organotypic cultures for recreating stratified epithelium from primary cell cultures
  • In limbal-corneal epithelial culturing and keratinocytes

Uses

Adenine is a purine nucleobase with a wide range of chemical and biochemical roles in vivo and in vitro. It is a regulatory molecule and a component of DNA, RNA, cofactors (NAD, FAD) and signaling molecules (cAMP).

Biological Activity

adenine hcl, a purine derivative and a nucleobase, plays crucial roles in substantial biochemistry processes in vivo, including cellular respiration, formation of the energy-rich adenosine triphosphate (atp), the cofactors nicotinamide adenine dinucleotide (nad) and flavin adenine dinucleotide (fad) as well as protein synthesis. in addition, adenine hcl also serves as a chemical component of dna and rna. adenosine triphosphate is used in cellular metabolism as one of the basic methods of transferring chemical energy between chemical reactions. [1]

in vitro

the cyto-protective effect of adenosine was measured using an in vitro model of acute tubular necrosis in rat kidney tubular cells. the finding suggested that adenosine at the concentration of 100 m could significantly decrease cellular injury. the ec50 value of adenosine was detected to be 14 m. [2]

in vivo

a study was performed to investigate the effects of dietary adenine on fatty liver induced by orotic acid (oa) in rats. 1% oa-supplemented diets with/ without 0.25% adenine was administered to rats for 10 days. enzyme assay kits were then applied to measure serum lipid profiles of tested rats, such as liver lipid concentrations in different treatment groups. moreover, the activities of fatty acid synthase (fas) and fatty acid β-oxidation were also detected. the findings suggested that addition of adenine to the diet offset the effect of oa and reversed promotion of liver tg content to basal level. administration of adenine also inhibited fas activities in rat liver. in conclusion, the ameliorating of fatty liver in adenine-treated rats was associated with the reduction of fas activities accompanied with the increase of mitochondrial fatty acid β-oxidation and the promotion of serum lipid secretion from the hepatic tissue into the bloodstream. [1]

storage

Desiccate at RT

References

[1]buang y. dietary adenine alleviates fatty liver induced by orotic acid. indo. j. chem. 2010; 10 (3): 363 - 369.
[2] módis k, ger d, nagy n, szoleczky p, tóth zd and szabó c. cytoprotective effects of adenosine and inosine in an in vitro model of acute tubular necrosis. br j pharmacol. 2009 nov; 158(6): 1565–8.

Adenine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Adenine hydrochloride manufacturers

Hebei Duling International Trade Co. LTD
Product
ADENINE HYDROCHLORIDE HEMIHYDRATE 2922-28-3
Price
US $70.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
30 tons
Release date
2023-07-05
Hebei Mojin Biotechnology Co., Ltd
Product
Adenine hydrochloride 2922-28-3
Price
US $60.00/KG
Min. Order
25KG
Purity
99.99%
Supply Ability
200ton
Release date
2023-08-15
Hebei Guanlang Biotechnology Co,.LTD
Product
Adenine hydrochloride 2922-28-3
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2023-06-26

2922-28-3, Adenine hydrochloride Related Search:


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