ChemicalBook > CAS DataBase List > 3-Cyano-7-hydroxycoumarin

3-Cyano-7-hydroxycoumarin

Product Name
3-Cyano-7-hydroxycoumarin
CAS No.
19088-73-4
Chemical Name
3-Cyano-7-hydroxycoumarin
Synonyms
3-CYANOUMBELLIFERONE;3-Cyanoumbelliferone>3-CYANO-7-HYDROXYCOUMARIN;3-Cyano-7-hydroxycoumarin 95+%;7-Hydroxy-2-oxochromene-3-carbonitrile;3-CYANOUMBELLIFERONE, FOR FLUORESCENCE*;7-hydroxy-2-oxo-2H-chromene-3-carbonitrile;3-Cyano-7-hydroxycoumarin *CAS 19088-73-4*;7-hydroxy-2-oxo-1-benzopyran-3-carbonitrile;3-Cyano-7-hydroxycoumarin ISO 9001：2015 REACH
CBNumber
CB1344231
Molecular Formula
C10H5NO3
Formula Weight
187.15
MOL File
19088-73-4.mol
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3-Cyano-7-hydroxycoumarin Property

Melting point:
≥250 °C(lit.)
Boiling point:
436.6±45.0 °C(Predicted)
Density 
1.50±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMF: soluble
pka
7.03 ± 0.20, most acidic, temperature: 25 °C
form 
powder to crystal
color 
Yellow solid or powder
λmax
408 nm (Buffer pH 9); 408 nm (MeOH)
BRN 
153271
Major Application
Electroluminescentdevice;laser dyes; modified polyester for foodcontainers/beverage bottles; monitoring of cationicphotopolymerization processes;textiles;thin films
Biological Applications
Detectingmicroorganisms,nucleic acids; inhibiting cellproliferation/tumor growth; reference standard foresters; ethers,phosphates substrates; asa substrate for measuring nucleic acid polymerasesactivity; treating viral or parasite infections
InChIKey
IJQYTHQDUDCJEQ-UHFFFAOYSA-N
CAS DataBase Reference
19088-73-4
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36
WGK Germany 
3
F 
8
HS Code 
2932.20.4500
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
28605
Product name
3-Cyanoumbelliferone
Purity
BioReagent, suitable for fluorescence, ≥98.0% (TLC)
Packaging
100mg
Price
$162
Updated
2025/07/31
Sigma-Aldrich
Product number
28605
Product name
3-Cyanoumbelliferone
Purity
BioReagent, suitable for fluorescence, ≥98.0% (TLC)
Packaging
500mg
Price
$619
Updated
2025/07/31
TCI Chemical
Product number
C2834
Product name
3-Cyanoumbelliferone
Purity
>98.0%(GC)
Packaging
1g
Price
$87
Updated
2025/07/31
TCI Chemical
Product number
C2834
Product name
3-Cyanoumbelliferone
Purity
>98.0%(GC)
Packaging
5g
Price
$259
Updated
2025/07/31
TRC
Product number
C991925
Product name
3-Cyanoumbelliferone
Packaging
500mg
Price
$310
Updated
2021/12/16
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3-Cyano-7-hydroxycoumarin Chemical Properties,Usage,Production

Uses

3-Cyanoumbelliferone is a calibration standard.

Uses

3-Cyano-7-hydroxycoumarin has been the most widely used fluorophores for preparing fluorogenic substrates.As a blue-fluorescent probe used as a reference standard.

Synthesis

105-56-6

95-01-2

19088-73-4

GENERAL METHOD: α-substituted ethyl acetate (1.0 mmol) and phenyl iododo diacetate (1.0 mmol) were dissolved in ethanol (5 mL) under continuous stirring conditions. After 10 min of reaction, benzaldehyde or salicylaldehyde (1.0 mmol) was added to the system and the reaction was continued with stirring until the appropriate time. The progress of the reaction was monitored by thin layer chromatography (TLC). After the TLC showed that the reaction was complete, the ethanol was evaporated under reduced pressure. Subsequently, the product was extracted with ethyl acetate and the organic phase was dried with anhydrous sodium sulfate (Na2SO4) and concentrated again under reduced pressure to remove the solvent. The resulting crude product was purified by recrystallization from a solvent mixture of ethyl acetate and hexane to finally obtain the target compound 7-hydroxy-2-oxochromene-3-carbonitrile (3a-3h and 4a-4r series derivatives).

References

[1] Synthetic Communications, 2005, vol. 35, # 6, p. 785 - 790
[2] Phosphorus, Sulfur and Silicon and the Related Elements, 2002, vol. 177, # 11, p. 2555 - 2559
[3] Tetrahedron Letters, 2017, vol. 58, # 32, p. 3183 - 3187
[4] Journal of Heterocyclic Chemistry, 2007, vol. 44, # 4, p. 867 - 870
[5] Journal of the Iranian Chemical Society, 2016, vol. 13, # 1, p. 149 - 153

3-Cyano-7-hydroxycoumarin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-Cyano-7-hydroxycoumarin manufacturers

R&D Scientific Inc.
Product
3-Cyano-7-hydroxycoumarin 19088-73-4
Price
US $2450.00/g
Min. Order
1g
Purity
98
Supply Ability
500 Kg
Release date
2024-09-06
Dideu Industries Group Limited
Product
3-Cyano-7-hydroxycoumarin 19088-73-4
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-11-01
Career Henan Chemical Co
Product
3-Cyano-7-hydroxycoumarin 19088-73-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2019-07-09

19088-73-4, 3-Cyano-7-hydroxycoumarinRelated Search:

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  • 7-Hydroxy-2-oxochromene-3-carbonitrile
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  • 3-Cyano-7-hydroxycoumarin *CAS 19088-73-4*
  • 7-hydroxy-2-oxo-1-benzopyran-3-carbonitrile
  • 3-Cyano-7-hydroxycoumarin 95+%
  • 3-Cyanoumbelliferone&gt
  • 2H-1-Benzopyran-3-carbonitrile, 7-hydroxy-2-oxo-
  • 3-Cyano-7-hydroxycoumarin ISO 9001：2015 REACH
  • 3-Cyanoumbelliferone (3-cyano-7-hydroxycoumarin), Fluorometric agent
  • 19088-73-4
  • C10H5NO3
  • Alphabetical
  • Fluorescent Indicators and Probes
  • Fluorescent Probes, Labels, Particles and Stains
  • pH Sensitive Probes and Indicators
  • Biochemicals and Reagents
  • BioChemical
  • heterocyclic/Aliphatic series
  • AMCA