ChemicalBook > CAS DataBase List > 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid

2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid

Product Name
2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid
CAS No.
4065-45-6
Chemical Name
2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid
Synonyms
BENZOPHENONE-4;BP-4;SULISOBENZONE;uvinul;UV-284;HMBS;5-BENZOYL-4-HYDROXY-2-METHOXYBENZENESULFONIC ACID;BIP1;2-HYDROXY-4-METHOXYBENZOPHENONE-5-SULPHONIC ACID;ms40
CBNumber
CB1359279
Molecular Formula
C14H12O6S
Formula Weight
308.31
MOL File
4065-45-6.mol
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2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid Property

Melting point:
170 °C
Boiling point:
0°C
Density 
1.4574 (rough estimate)
vapor pressure 
0Pa at 25℃
refractive index 
1.5300 (estimate)
Flash point:
0°C
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
-0.70±0.50(Predicted)
color 
White to Off-White
Water Solubility 
300.92g/L at 25℃
Merck 
14,8983
BRN 
2889165
InChIKey
CXVGEDCSTKKODG-UHFFFAOYSA-N
LogP
0.515 at 25℃
CAS DataBase Reference
4065-45-6(CAS DataBase Reference)
EPA Substance Registry System
Sulisobenzone (4065-45-6)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39-36/37/39-27
WGK Germany 
1
RTECS 
DB5044300
TSCA 
Yes
HS Code 
29147000
Hazardous Substances Data
4065-45-6(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1642100
Product name
Sulisobenzone
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
500mg
Price
$483
Updated
2024/03/01
Sigma-Aldrich
Product number
09649
Product name
5-Benzoyl-4-hydroxy-2-methoxybenzenesulfonic acid
Purity
≥97.0% (HPLC)
Packaging
10g
Price
$114
Updated
2024/03/01
TCI Chemical
Product number
H0466
Product name
2-Hydroxy-4-methoxybenzophenone-5-sulfonic Acid Hydrate(contains 5-10% Isopropyl Alcohol)
Purity
>98.0%(T)
Packaging
25g
Price
$49
Updated
2024/03/01
TCI Chemical
Product number
H0466
Product name
2-Hydroxy-4-methoxybenzophenone-5-sulfonic Acid Hydrate(contains 5-10% Isopropyl Alcohol)
Purity
>98.0%(T)
Packaging
500g
Price
$334
Updated
2024/03/01
Alfa Aesar
Product number
L12912
Product name
2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid hydrate, tech. 85%, may cont. up to 10% 2-propanol
Packaging
10g
Price
$66.65
Updated
2024/03/01
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2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid Chemical Properties,Usage,Production

Chemical Properties

white to yellowish powder

Originator

Uval,Dome,US,1965

Uses

sulisobenzone is the drug name for benzophenone-4, a sunscreen chemical.

Uses

ultraviolet screen

Uses

Ultraviolet absorber for leather and textile fibers; in cosmetics and shampoos.

Uses

2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid is a commonly used, FDA approved sunscreen chemical with uVA-absorbing properties and an approved usage level of 5 to 10 percent. It protects a formulation from the effects of uV-light exposure.

Definition

ChEBI: Sulisobenzone is a member of benzophenones.

Manufacturing Process

663 g of dichloroethane and 74.6 g 2-hydroxy-4-methoxybenzophenone were charged into a 3-neck flask equipped with stirrer, thermometer, reflux condenser and dropping funnel and a heating mantle. The solution was heated to the reflux temperature (85°C to 86°C) and was dehydrated by distilling off 66.5 g 1,2-dichloroethane. While maintaining at reflux, 30 g chlorosulfonic acid was added slowly over a period of about two hours. The rate of addition was regulated by the speed of evolution of the HCl. After all the chlorosulfonic acid was added, the charge was still maintained at reflux for an additional 15 minutes to remove traces of HCl. It was then cooled to 5°C and filtered. The filter cake was washed with 500 g cold 1,2-dichloroethane and dried. 98 g of product were obtained.

brand name

Sungard (Bayer).

Therapeutic Function

Sunscreen agent

General Description

Sulisobenzone is a broad spectrum organic UV filter in sunscreen formulations, known to absorb deleterious UV light.

Flammability and Explosibility

Non flammable

Contact allergens

BZP-4 is widely used in cosmetics, particularly shampoos and hair products. Cross-reactivity is rarely expected in patients photoallergic to ketoprofen.

2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid Preparation Products And Raw materials

Raw materials

1,3-Dimethoxybenzene Resorcinol

Preparation Products

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2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid Suppliers

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View Lastest Price from 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
UV ABSORBER HMBS 4065-45-6
Price
US $0.10-0.10/KG
Min. Order
10KG
Purity
99%+
Supply Ability
1000KG
Release date
2024-04-24
Qingdao Truelight functional Material Technology Co., Ltd.
Product
UV ABSORBER TRUELICHT BP-4 4065-45-6
Price
US $0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
1000tons
Release date
2023-05-03
Hebei Shengyang Water Conservancy Engineering Co., Ltd.
Product
UV-284 Benzophenone-4 4065-45-6
Price
US $18.00-18.00/kg
Min. Order
1kg
Purity
99.9
Supply Ability
5000
Release date
2024-05-10

4065-45-6, 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acidRelated Search:

Benzoyl chloride (Trifluoromethoxy)benzene Octabenzone Oxybenzone CHLOROPHOSPHONAZO III UV-329 Drometrizole Benzophenone Benzoyl peroxide 4-Hydroxybenzophenone Ethyl 4-[[(methylphenylamino)methylene]amino]benzoate UV Absorber 326 4-Methylbenzophenone 2-Phenylbenzimidazole-5-sulfonic acid 4-Methoxybenzophenone 3-Aminophenol Phenol Red Phenol

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  • 5-Benzoyl-4-hydroxy-2-methoxybenzene sulfonic aid
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