2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid
- Product Name
- 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid
- CAS No.
- 4065-45-6
- Chemical Name
- 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid
- Synonyms
- BENZOPHENONE-4;BP-4;SULISOBENZONE;uvinul;UV-284;HMBS;5-BENZOYL-4-HYDROXY-2-METHOXYBENZENESULFONIC ACID;BIP1;2-HYDROXY-4-METHOXYBENZOPHENONE-5-SULPHONIC ACID;ms40
- CBNumber
- CB1359279
- Molecular Formula
- C14H12O6S
- Formula Weight
- 308.31
- MOL File
- 4065-45-6.mol
2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid Property
- Melting point:
- 170 °C
- Boiling point:
- 0°C
- Density
- 1.4574 (rough estimate)
- vapor pressure
- 0Pa at 25℃
- refractive index
- 1.5300 (estimate)
- Flash point:
- 0°C
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- -0.70±0.50(Predicted)
- form
- Solid
- color
- White to Off-White
- Water Solubility
- 300.92g/L at 25℃
- Merck
- 14,8983
- BRN
- 2889165
- InChIKey
- CXVGEDCSTKKODG-UHFFFAOYSA-N
- LogP
- 0.515 at 25℃
- CAS DataBase Reference
- 4065-45-6(CAS DataBase Reference)
- EPA Substance Registry System
- Sulisobenzone (4065-45-6)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39-36/37/39-27
- WGK Germany
- 1
- RTECS
- DB5044300
- TSCA
- Yes
- HS Code
- 29147000
- Hazardous Substances Data
- 4065-45-6(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 1642100
- Product name
- Sulisobenzone
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 500mg
- Price
- $483
- Updated
- 2024/03/01
- Product number
- 09649
- Product name
- 5-Benzoyl-4-hydroxy-2-methoxybenzenesulfonic acid
- Purity
- ≥97.0% (HPLC)
- Packaging
- 10g
- Price
- $114
- Updated
- 2024/03/01
- Product number
- H0466
- Product name
- 2-Hydroxy-4-methoxybenzophenone-5-sulfonic Acid Hydrate(contains 5-10% Isopropyl Alcohol)
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $49
- Updated
- 2024/03/01
- Product number
- H0466
- Product name
- 2-Hydroxy-4-methoxybenzophenone-5-sulfonic Acid Hydrate(contains 5-10% Isopropyl Alcohol)
- Purity
- >98.0%(T)
- Packaging
- 500g
- Price
- $334
- Updated
- 2024/03/01
- Product number
- L12912
- Product name
- 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid hydrate, tech. 85%, may cont. up to 10% 2-propanol
- Packaging
- 10g
- Price
- $66.65
- Updated
- 2024/03/01
2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid Chemical Properties,Usage,Production
Description
UV light absorber 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid (INCI title Benzophenone-4; Hereinafter to be referred to as BP-4) can absorb UV-A and UV-B simultaneously; Be a kind of wide spectrum, water-soluble UV light absorber; To advantages such as light, Heat stability is goods, be used for water-soluble makeup and make sun-screening agent. Being the cosmetics additive that Europe and Japanese rules allow use, it is also the first kind of sun-screening agent of drugs approved by the FDA and is simultaneously the UV light absorber that China's cosmetics health standard (2002 editions) permission. Its acute toxicity: the oral medium lethal dose LD50=3530mg/kg of mouse belongs to the low toxicity chemical.
Chemical Properties
white to yellowish powder
Originator
Uval,Dome,US,1965
Uses
Ultraviolet absorber for leather and textile fibers; in cosmetics and shampoos.
Uses
2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid is a commonly used, FDA approved sunscreen chemical with uVA-absorbing properties and an approved usage level of 5 to 10 percent. It protects a formulation from the effects of uV-light exposure. Sulisobenzone is the drug name for benzophenone-4, a sunscreen chemical.
Definition
ChEBI: Sulisobenzone is a member of benzophenones.
Manufacturing Process
663 g of dichloroethane and 74.6 g 2-hydroxy-4-methoxybenzophenone were charged into a 3-neck flask equipped with stirrer, thermometer, reflux condenser and dropping funnel and a heating mantle. The solution was heated to the reflux temperature (85°C to 86°C) and was dehydrated by distilling off 66.5 g 1,2-dichloroethane. While maintaining at reflux, 30 g chlorosulfonic acid was added slowly over a period of about two hours. The rate of addition was regulated by the speed of evolution of the HCl. After all the chlorosulfonic acid was added, the charge was still maintained at reflux for an additional 15 minutes to remove traces of HCl. It was then cooled to 5°C and filtered. The filter cake was washed with 500 g cold 1,2-dichloroethane and dried. 98 g of product were obtained.
brand name
Sungard (Bayer).
Therapeutic Function
Sunscreen agent
General Description
Sulisobenzone is a broad spectrum organic UV filter in sunscreen formulations, known to absorb deleterious UV light.
Flammability and Explosibility
Non flammable
Contact allergens
BZP-4 is widely used in cosmetics, particularly shampoos and hair products. Cross-reactivity is rarely expected in patients photoallergic to ketoprofen.
Synthesis
Adding 2-hydroxy-4-methoxybenzophenone and a solvent into an enamel reaction kettle, dripping chlorosulfonic acid under the protection of nitrogen with stirring, controlling the temperature of materials in the kettle to be 20 to 25 DEG C through jacket water bath cooling by controlling the dripping speed of the chlorosulfonic acid, and reacting for 20 to 25 hours; performing centrifugal filtering separation on a product after the reaction is finished, washing the product by using the corresponding solvent, and drying the product under the protection of the nitrogen; and recycling a hydrogen chloride (HCl) byproduct in an HCl recycling packed tower in a water circulation mode to form a 20 to 30 % hydrochloric acid aqueous solution, and recycling the 2-hydroxy-4-methoxybenzophenone and the 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid from raffinate at the bottom of the kettle.
Regulations
2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid is a cosmetic material; the allowance state of countries in the world (maximum usage quantity wt%) is as follows: Europe: 5.0%; Australia: 10%; Japan: 10.0%; The U.S.: 10.0%; China: 5%.
2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid Preparation Products And Raw materials
Raw materials
Preparation Products
2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid Suppliers
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View Lastest Price from 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid manufacturers
- Product
- 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid 4065-45-6
- Price
- US $0.00-0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 1000kg
- Release date
- 2021-11-04
- Product
- 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid 4065-45-6
- Price
- US $3.50/kg
- Min. Order
- 1kg
- Purity
- ≥99%
- Supply Ability
- 3000tons/month
- Release date
- 2024-08-25
- Product
- UV-284 Benzophenone-4 4065-45-6
- Price
- US $120.00-65.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-04-26