5-Amino-1,3,4-thiadiazole-2-thiol

Product Name: 5-Amino-1,3,4-thiadiazole-2-thiol
CAS No.: 2349-67-9
Chemical Name: 5-Amino-1,3,4-thiadiazole-2-thiol
Synonyms: 2-Amino-5-mercapto-1,3,4-thiadiazole;2-Amino-5-mercapto-1,3,4-thiad;2-Mercapto-5-amino-1,3,4-thiadiazole;1,3,4-Thiadiazole-2(3H)-thione, 5-amino-;EAMTD;nsc21402;NSC 21402;usafpd-25;USAF pd-25;Acetazolamide EP Impurity G
CBNumber: CB1360123
Molecular Formula: C2H3N3S2
Formula Weight: 133.2
MOL File: 2349-67-9.mol

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5-Amino-1,3,4-thiadiazole-2-thiol Property

Melting point:: 235 °C (dec.)(lit.)
Boiling point:: 242.3±23.0 °C(Predicted)
Density: 1.503 (estimate)
refractive index: 1.5800 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: 2g/l
form: Powder
pka: 7.80±0.20(Predicted)
color: White or pale yellow to cream
PH: 3.9 (2g/l, H2O, 20℃)
Water Solubility: insoluble
BRN: 81728
InChIKey: GDGIVSREGUOIJZ-UHFFFAOYSA-N
CAS DataBase Reference: 2349-67-9(CAS DataBase Reference)
NIST Chemistry Reference: 2-Amino-5-mercapto-1,3,4-thiadiazole(2349-67-9)
EPA Substance Registry System: 1,3,4-Thiadiazole-2(3H)-thione, 5-amino- (2349-67-9)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-22-20/21/22
Safety Statements: 26-36-36/37
WGK Germany: 3
RTECS: XI4550000
F: 9-13-23
Hazard Note: Irritant
TSCA: Yes
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 127906
Product name: 5-Amino-1,3,4-thiadiazole-2-thiol
Purity: 98%
Packaging: 50g
Price: $88.6
Updated: 2023/01/07

TCI Chemical

Product number: A0425
Product name: 2-Amino-5-mercapto-1,3,4-thiadiazole
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $22
Updated: 2025/07/31

TCI Chemical

Product number: A0425
Product name: 2-Amino-5-mercapto-1,3,4-thiadiazole
Purity: >98.0%(HPLC)(T)
Packaging: 500g
Price: $187
Updated: 2025/07/31

TRC

Product number: A633300
Product name: 5-Amino-1,3,4-thiadiazole-2-thiol
Packaging: 1g
Price: $55
Updated: 2021/12/16

Apolloscientific

Product number: OR28655
Product name: 2-Amino-5-thio-1,3,4-thiadiazole
Purity: 99%
Packaging: 100g
Price: $56
Updated: 2021/12/16

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5-Amino-1,3,4-thiadiazole-2-thiol Chemical Properties,Usage,Production

Chemical Properties

White or pale yellow to cream powder

Uses

5-Amino-1,3,4-thiadiazole-2-thiol is a thiadiazole derivative with antibacterial acitivity used in the preparation of herbicides as well as carbonic anhydrase inhibitors.

Uses

5-amino-1,3,4-thiadiazole-2-thiol was used to prepare new amines exhibiting anti-convulsant activity.

Synthesis

75-15-0

79-19-6

2349-67-9

2-Amino-5-mercapto-1,3,4-thiadiazole was synthesized as follows: in a three-necked flask equipped with a stirrer, 5.5 g (0.06 mol) of aminothiourea, 20 mL of N,N-dimethylformamide (DMF), and 3 mL (0.1 mol) of carbon disulfide were added sequentially. The reaction mixture was heated to reflux and maintained for 4 hours. After completion of the reaction, the mixture was cooled to room temperature. To the reaction mixture was added 40 mL of 2 mol/L sodium hydroxide solution followed by decolorization. After decolorization, concentrated hydrochloric acid was slowly added to acidic conditions to precipitate the crude product. The crude product was purified by recrystallization from 50% ethanol to give 5.7 g of bright yellow needle-like crystals of 2-amino-5-mercapto-1,3,4-thiadiazole in 67.4% yield.

References

[1] Journal of Chemical Research, 2010, # 11, p. 619 - 621
[2] Chemical Biology and Drug Design, 2012, vol. 80, # 4, p. 598 - 604
[3] European Journal of Medicinal Chemistry, 2006, vol. 41, # 8, p. 918 - 924
[4] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2010, vol. 49, # 2, p. 241 - 246
[5] Chemical Biology and Drug Design, 2013, vol. 81, # 5, p. 666 - 673

5-Amino-1,3,4-thiadiazole-2-thiol Preparation Products And Raw materials

Raw materials

2-Mercapto-5-methyl-1,3,4-thiadiazole Hydrazine sulfate Calcium phosphate RHENIUM Hydrazodicarbothioamide Ammonium thiocyanate

Preparation Products

2-(ACETAMIDO)-5-(CHLOROSULFONYL)-1,3,4-THIADIAZOLE 2-Acetylamino-5-mercapto-1,3,4-thiadiazole

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5-Amino-1,3,4-thiadiazole-2-thiol Suppliers

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View Lastest Price from 5-Amino-1,3,4-thiadiazole-2-thiol manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 5-Amino-1,3,4-thiadiazole-2-thiol 2349-67-9
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-21

Henan Aochuang Chemical Co.,Ltd.

Product: 5-Amino-1,3,4-thiadiazole-2-thiol 2349-67-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-27

Hebei Dangtong Import and export Co LTD

Product: 5-Amino-1,3,4-thiadiazole-2-thiol 2349-67-9
Price: US $21.00-15.00/kg
Min. Order: 10kg
Purity: 98%
Supply Ability: 300tons
Release date: 2024-09-11

2349-67-9, 5-Amino-1,3,4-thiadiazole-2-thiolRelated Search:

2-Mercapto-5-methyl-1,3,4-thiadiazole 2,1,3-Benzothiadiazole 3-Mercaptopropionic acid 2-Mercapto-1,3,4-thiadiazol Glycine Calcium thioglycolate ALTRENOGEST 3-Aminophenol Sodium thioglycolate 2-Amino-1,3,4-thiadiazole 2-Ethylhexyl mercaptoacetate Mercaptoacetic acid 6-Aminocaproic acid Acetazolamide 2-Acetylamino-5-mercapto-1,3,4-thiadiazole ACETAZOLAMIDE-D3 Tris(hydroxymethyl)aminomethane N,N'-[IMinobis(sulfonyl-1,3,4-thiadiazole-5,2-diyl)]bisacetaMide

ACETYLAMINE(2-)-5-MERCAPTO-1,3,4-THIADAZOLE

1,3,4-Thiadiazole-2(3H)-thione, 5-amino-

1,3,4-Thiadiazole-2-thiol, 5-amino-

5-Amino-2-mercapto-1,3,4-thiadiazole

5-Amino-2-thiol-1,3,4-thiadiazole

5-Amino-3H-[1,3,4]thiadiazole-2-thione

delta2-1,3,4-Thiadiazoline-2-thiol, 5-imino-

NSC 21402

nsc21402

USAF pd-25

usafpd-25

EAMTD

AMTD 2-Amino-5-mercapto-1,3,4-thiadiazole

Acetazolamide EP Impurity G

2-amino-5-mercapto-1,3,4-thiiodiazole

5-amino-1,3,,4-thialiazoline-2(3H)-thione

2-Amino-5-mercapto-1,3,4-thiad

2-Amino-1,3,4-thiadiazole-5-mercaptan

2-Amino-1,3,4-thiadiazole-5-thiol

2-Amino-5-mercapto-1,3,4-thiadiazole(AMTD)

2-Amino-5-mercaptothiadiazole

2-amino-delta(2)-1,3,4-thiadiazoline-5-thione

2-Amino-delta2-1,3,4-thiadiazoline-5-thione

2-Mercapto-5-amino-1,3,4-thiadiazole

2-Thiol-5-amino-1,3,4-thiadiazole

3,4-Thiadiazole-2(3H)-thione,5-amino-1

Pesticide InterMediates

2-amino-5-mercapto-1,3,4-thiadiazol

AMino - 5-2 - Mercapto - 1 and 4 - consult in 1

5-Amino-1,3,4-thiadiazole-2-thiol 98%

2-Amino-5-mercapto-1,3,4-thiadiazole for synthesis

5-Amino-1,3,4-thiadiazole-2(3H)-thione Solution, 100ppm

Acetazolamide Impurity 7(Acetazolamide EP Impurity G)

5-Amino-1,3,4-thiadiazoL

e-2-thioL

2-Amino-5-mercapto-1,3,4-thiadiazole

5-Amino-1,3,4-thiadiazole-2-thiol

4-thiadiazole-2(3h)-thione,5-amino-3

4-thiadiazole-2-thiol,5-amino-3

5-amino-1,3,4-thiadiazole-2(3h)-thione

5-Amino-1,3,4-thiadiazoline-2-thione

2-amino-5-mrecapto-1,3,4-thiadiazol

2-AMINO-5-MERCAPTO-1,3,4-THIADIAZOLE /AMT

5-Amino-1,3,4-thiadiazole-2-thiol,98%

5-Amino-1,3,4-thiadi

2-AMino-5-Mercapto-1

5-AMino-1,3,4-thiadiazole-2-thiol, 98% 25GR

5-AMino-1,3,4-thiadiazole-2-thiol, 98% 50GR

2-AMINO-5-MERCAPTO-1,3,4-THIADIAZOLE FOR

2-Amino-5-mercapto-1,3,4-thiadiazole, 5-Amino-1,3,4-thiadiazole-2-thiol

2-Amino-5-thio-1,3,4-thiadiazole

2-Amino-5-mercapto-1,3,4-thiadiazole, 98+%

5-Amino-1,3,4-thiazole-2-thiol

2-amino thiadiazole-5-thiol

5-Mercapto-1,3,4-thiadiazole-2-amine

5-Mercapto-2-amino-1,3,4-thiadiazole

2-amino-5-mercapto-1,3,4-triazole

2-Amino-5-mercapto-1,3,4-thiadiazole &gt