2-Amino-3,5-dibromo-4-methylpyridine
- Product Name
- 2-Amino-3,5-dibromo-4-methylpyridine
- CAS No.
- 3430-29-3
- Chemical Name
- 2-Amino-3,5-dibromo-4-methylpyridine
- Synonyms
- 3,5-Dibromo-4-methylpyridin-2-amine;2-Amino-3,5-dibromo-4-methyL;2-Amino-3,5-Dibromo-4-pioline;2-AMINO-3,5-DIBROMO-4-PICOLINE;3,5-DIBROMO-4-METHYL-2-PYRIDINAMINE;2-AMINO-3,5-DIBROMO-4-METHYLPRIDINE;2-AMINO-3,5-DIBROMO-4-METHYPYRIDINE;2-AMINO-3,5 DIBROMO-4-METHYL PYRIDINE;2-Pyridinamine, 3,5-dibromo-4-methyl-;3,5-DibroMo-4-Methyl-pyridin-2-ylaMine
- CBNumber
- CB1361584
- Molecular Formula
- C6H6Br2N2
- Formula Weight
- 265.93
- MOL File
- 3430-29-3.mol
2-Amino-3,5-dibromo-4-methylpyridine Property
- Melting point:
- 123-124 °C
- Boiling point:
- 276.5±35.0 °C(Predicted)
- Density
- 1.990±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- solid
- pka
- 2.52±0.50(Predicted)
- color
- Off white
- InChI
- InChI=1S/C6H6Br2N2/c1-3-4(7)2-10-6(9)5(3)8/h2H,1H3,(H2,9,10)
- InChIKey
- LLGXZSVWYCKUBB-UHFFFAOYSA-N
- SMILES
- C1(N)=NC=C(Br)C(C)=C1Br
- CAS DataBase Reference
- 3430-29-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H341Suspected of causing genetic defects
H351Suspected of causing cancer
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A576678
- Product name
- 2-Amino-3,5-dibromo-4-methylpyridine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 026738
- Product name
- 2-Amino-3,5-dibromo-4-methylpyridine
- Purity
- 98%
- Packaging
- 5g
- Price
- $14
- Updated
- 2021/12/16
- Product number
- 3H30-9-Y8
- Product name
- 2-Amino-3,5-dibromo-4-methylpyridine
- Packaging
- 5G
- Price
- $16
- Updated
- 2021/12/16
- Product number
- 026738
- Product name
- 2-Amino-3,5-dibromo-4-methylpyridine
- Purity
- 98%
- Packaging
- 25g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 3H30-9-Y8
- Product name
- 2-Amino-3,5-dibromo-4-methylpyridine
- Packaging
- 25g
- Price
- $58
- Updated
- 2021/12/16
2-Amino-3,5-dibromo-4-methylpyridine Chemical Properties,Usage,Production
Synthesis
695-34-1
3430-29-3
a) Preparation of 2-amino-3,5-dibromo-4-methylpyridine: 2-amino-4-methylpyridine (30.0 g, 0.277 mol) was dissolved in 72% sulfuric acid (130 mL) and cooled to 0°C in an ice bath. Bromine (21.5 mL, 0.416 mol) was added slowly dropwise with stirring, and the rate of dropwise acceleration was controlled to keep the reaction temperature at 0 °C. After the dropwise addition, the reaction mixture was gradually warmed to 25 °C and the reaction was stirred at this temperature for 18 hours. Upon completion of the reaction, the reaction solution was slowly poured into ice water and the pH was adjusted with 50% sodium hydroxide solution to 10. At this point, the target product 2-amino-3,5-dibromo-4-methylpyridine precipitated as a solid, which was collected by filtration. The filtrate was extracted with dichloromethane, the organic layers were combined and dried over anhydrous magnesium sulfate. The dried organic phase was concentrated and the resulting solid was combined with the solid obtained by previous filtration and further purified by fast column chromatography (eluent: 2% methanol/dichloromethane) to give the final white solid product 2-amino-3,5-dibromo-4-methylpyridine (42.7 g, 58% yield). The structure of the product was confirmed by 1H NMR (CDCl3): δ 8.08 (s, 1H), 4.95 (bs, 2H), 2.51 (s, 3H).
References
[1] Patent: US6440993, 2002, B1
[2] Patent: US2005/277668, 2005, A1. Location in patent: Page/Page column 27-28
[3] Journal of Medicinal Chemistry, 2017, vol. 60, # 24, p. 10056 - 10070
2-Amino-3,5-dibromo-4-methylpyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2-Amino-3,5-dibromo-4-methylpyridine Suppliers
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- --
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- info@specs.net
- Country
- The Netherlands
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View Lastest Price from 2-Amino-3,5-dibromo-4-methylpyridine manufacturers
- Product
- 2-Amino-3,5-dibromo-4-methylpyridine 3430-29-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-30
- Product
- 2-Amino-3,5-dibromo-4-methylpyridine 3430-29-3
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08
- Product
- 2-Amino-3,5-dibromo-4-methylpyridine 3430-29-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-25