Colistin sodium methanesulfonate
- Product Name
- Colistin sodium methanesulfonate
- CAS No.
- 8068-28-8
- Chemical Name
- Colistin sodium methanesulfonate
- Synonyms
- Colistin Methanesulfonate;Colistimethate sodium CRS;COLISTIN SODIUM METHANESULFONATE;w1929;Promixi;colistinat;colimycinm;colymycinm;Coly-mycin M (TN);colistinsulfomethat
- CBNumber
- CB1371673
- Molecular Formula
- Unspecified
- Formula Weight
- 1749.82
- MOL File
- 8068-28-8.mol
Colistin sodium methanesulfonate Property
- Melting point:
- >228°C (dec.)
- storage temp.
- 2-8°C
- solubility
- H2O: soluble10mg/mL
- form
- powder
- color
- white to faintly beige
- PH
- 6-8 (10mg/mL in H2O)
- Water Solubility
- Freely soluble in water
- Merck
- 13,2503
- CAS DataBase Reference
- 8068-28-8
- EPA Substance Registry System
- Colistimethate sodium (8068-28-8)
Safety
- RIDADR
- 3249
- WGK Germany
- 2
- RTECS
- GH1650000
- F
- 3
- TSCA
- Yes
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 2941906000
- Toxicity
- LD50 i.v. in mice: >550 mg/kg (Barnett)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H361Suspected of damaging fertility or the unborn child
H362May cause harm to breast-fed children
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P263Avoid contact during pregnancy/while nursing.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P281Use personal protective equipment as required.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- Y0001887
- Product name
- E1 Colistimethate sodium for peak identification
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- Y0001887
- Price
- $153
- Updated
- 2024/03/01
- Product number
- Y0001886
- Product name
- E2 Colistimethate sodium for peak identification
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- Y0001886
- Price
- $153
- Updated
- 2024/03/01
- Product number
- C1511
- Product name
- Colistin sodium methanesulfonate
- Purity
- ~11,500?U/mg
- Packaging
- 10000000units
- Price
- $246
- Updated
- 2024/03/01
- Product number
- C1511
- Product name
- Colistin sodium methanesulfonate
- Purity
- ~11,500?U/mg
- Packaging
- 100000000units
- Price
- $1530
- Updated
- 2024/03/01
- Product number
- 1147009
- Product name
- Colistimethate sodium
- Packaging
- 200mg
- Price
- $447
- Updated
- 2024/03/01
Colistin sodium methanesulfonate Chemical Properties,Usage,Production
Chemical Properties
White or almost white, hygroscopic powder.
Uses
Colistin sodium methanesulfate is used to permeabilize bacterial cell membranes and to study mannose-resistant haemagglutination. It is used to study effective treatments of P. aeruginosa infections in cystic fibrosis patients and to study the pharmacokinetics and BAL concentration of colistin in critically ill patients.
Definition
ChEBI: A mixture where R = H or Me. Colistin in which each of the primary amino groups is converted to the corresponding aminomethanesulfonic acid sodium salt, commonly by the action of formaldehyde followed by sodium bisulfite. A polymyxin antibiotic derivative, it is used in the treatment of severe infections, particularly of multidrug-resistant Gram-negative bacteria such as Pseudomonas aeruginosa and Acinetobacter baumannii.
brand name
Coly-Mycin (Monarch).
General Description
Two forms of colistins, colistin sulfate and colistin methanesulfonate sodium (Colistin sodium methanesulfonate)(CMS-Na), are commercially available. CMS-Na is administered intravenously, and CMS, the free base of CMS-Na consisting of CMS A and CMS B, is hydrolyzed in vivo to form active colistin A and colistin B6 . Colistin first became available for clinical use in 1959 and has been used worldwide for several decades[5].
Biological Activity
colistin methanesulfonate is an inactive prodrug of colistin (also known as polymyxin e), which is an antibiotic with effect against most gram-negative bacteria, but also causes nephro- and neurotoxicity [1]. colistin is produced by certain strains of the bacteria paenibacillus polymyxa, and belongs to the class of polypeptide antibiotics known as polymyxins.in vitro: studying the time-kill kinetics of colistin methanesulfonate against a type culture of pseudomonas aeruginosa found that 8.0 or 32 mg/l colistin methanesulfonate began killing at approximately 90 or 30 min, and the mean auc0-240 values were 186.3±6.0 and 90.4±4.1, respectively [2]. besides, by investigation among mucoid and nonmucoid strains of pseudomonas aeruginosa isolated from patients with cystic fibrosis, colistin methanesulfonate was found to require a concentration of 16 times the mic to achieve complete killing within 24 h [3].
Pharmacokinetics
Colistin is administered intravenously as the non-active prodrug, colistin methanesulfonate sodium (CMS). Colistin methanesulfonate sodium (Colistin sodium methanesulfonate) is eliminated mainly by renal clearance. If CMS is cleared rapidly by the kidney, less CMS is converted to colistin resulted in low colistin that could lead to ineffective antibacterial therapy. In patients with normal renal function (1–2 MIU of CMS), approximately 30–60% of a dose of CMS is converted to colistin. The renal clearance of CMS is much more efficient than the conversion of CMS to colistin. Therefore, to achieve a targeted concentration of >2 mg/L, patients must receive four to five times the amount of CMS. There was wide variability of colistin Cmax values (0.6–8.7 mg/L) in plasma among single-dose studies receiving 2–3 MIU of CMS in critically ill patients with preserved renal function. Almost none of the ICU patients achieved a colistin concentration of more than 2 mg/L in the Plachouras et al. and Mohamed et al. studies[4].
Safety Profile
Human poison by intramuscular route. Experimental poison by intramuscular, intraperitoneal, subcutaneous, and intravenous routes. Mildly toxic by ingestion. An experimental teratogen. Human systemic effects by intramuscular route: convulsions or effect on seizure threshold, change in motor activity, change in lrldney tubules, and urine volume decrease or anuria. Experimental reproductive effects. Used as an antibiotic. When heated to decomposition it emits very toxic fumes of NOx, SOx, and NazO
References
[1] Yusuf, Wan Nazirah Wan . "Population Pharmacokinetics of Colistin Methanesulfonate Sodium and Colistin in Critically Ill Patients: A Systematic Review." Pharmaceuticals 14(2021).
References
[1] nation r l, li j. colistin in the 21st century.[j]. current opinion in infectious diseases, 2009, 22(6): 535-543.
[2] bergen p j, li j, rayner c r, et al. colistin methanesulfonate is an inactive prodrug of colistin against pseudomonas aeruginosa.[j]. antimicrobial agents and chemotherapy, 2006, 50(6): 1953-1958.
[3] li j, turnidge j d, milne r w, et al. in vitro pharmacodynamic properties of colistin and colistin methanesulfonate against pseudomonas aeruginosaisolates from patients with cystic fibrosis[j]. antimicrobial agents and chemotherapy, 2001, 45(3): 781-785.
[4] Yusuf, Wan Nazirah Wan . "Population Pharmacokinetics of Colistin Methanesulfonate Sodium and Colistin in Critically Ill Patients: A Systematic Review."Pharmaceuticals14(2021).
[5] Mizuyachi, Kaori , et al. "Safety and pharmacokinetic evaluation of intravenous colistin methanesulfonate sodium in Japanese healthy male subjects."Current Medical Research and Opinion27.12(2011):2261-2270.
Colistin sodium methanesulfonate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Colistin sodium methanesulfonate manufacturers
- Product
- Colistimethate Sodium 8068-28-8
- Price
- US $0.00/Kg/Bag
- Min. Order
- 2Kg/Bag
- Purity
- 99% up, High Density
- Supply Ability
- 20 tons
- Release date
- 2021-07-19
- Product
- COLISTIN METHANESULFONATE SODIUM SALT 8068-28-8
- Price
- US $0.00/KG/Tin
- Min. Order
- 5KG
- Purity
- ≥390μg/mg; USP
- Supply Ability
- 100KG/Month
- Release date
- 2021-06-25
- Product
- Colistin sodium methanesulfonate 8068-28-8
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2023-07-04