Isopropyl unoprostone

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Isopropyl unoprostone

Product Name: Isopropyl unoprostone
CAS No.: 120373-24-2
Chemical Name: Isopropyl unoprostone
Synonyms: UF-021;Rescul;RESCULA;Unii-5m161S5o5p;ISOPROPY UNOPROSTONE;isopropyl unoprostone;UNOPROSTONE ISOPROPYL ESTER;Isopropyl unoprostone USP/EP/BP;Uroprostaglandin isopropyl ester;13,14-dihydro-15-keto-20-ethyl-pgf
CBNumber: CB1392171
Molecular Formula: C25H44O5
Formula Weight: 424.61
MOL File: 120373-24-2.mol

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Isopropyl unoprostone Property

Boiling point:: 546.3±45.0 °C(Predicted)
Density: 1.019±0.06 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
form: Oil
pka: 14.79±0.70(Predicted)
color: Clear Colourless
CAS DataBase Reference: 120373-24-2(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H302Harmful if swallowed

H319Causes serious eye irritation

H336May cause drowsiness or dizziness

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16681
Product name: Unoprostone isopropyl ester
Purity: ≥98%
Packaging: 1mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 16681
Product name: Unoprostone isopropyl ester
Purity: ≥98%
Packaging: 5mg
Price: $257
Updated: 2024/03/01

Cayman Chemical

Product number: 16681
Product name: Unoprostone isopropyl ester
Purity: ≥98%
Packaging: 10mg
Price: $456
Updated: 2024/03/01

Cayman Chemical

Product number: 16681
Product name: Unoprostone isopropyl ester
Purity: ≥98%
Packaging: 50mg
Price: $1853
Updated: 2024/03/01

TRC

Product number: U800050
Product name: UnoprostoneIsopropylEster
Packaging: 5mg
Price: $880
Updated: 2021/12/16

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Isopropyl unoprostone Chemical Properties,Usage,Production

Description

Unoprostone isopropyl ester, a novel prostaglandin derivative, was launched in Japan as eye drops for the treatment of glaucoma and ocular hypertension. In animal and human studies, a single drop of unoprostone isopropyl ester induced significant decrease in intraocular pressure without systemic effects, myosis or mydriasis. Unlike prostaglandin analogs such as PGF_2α, unoprostone isopropyl ester does not cause irritation in outer segment of the eye or significant changes in aqueous protein concentration and corneal endothelial permeability. Unoprostone isopropyl ester is suggested to act by increasing uveoscleral outflow or by decreasing episcleral venous pressure, resulting in ocular hypotension.

Description

Unoprostone isopropyl ester (Rescula) is the clinically approved, prodrug form of unoprostone, which is a free acid analog of prostaglandin F_2α (PGF_2α). Both latanoprost and Rescula have been approved for the treatment of ocular hypertension. Both analogs of PGF_2α are believed to act by increasing the rate of aqueous humor outflow through the uveoscleral pathway. Both drugs are believed to act as prodrugs, with endogenous esterases within the eye releasing the free acid active form of the drug. The typical does of Rescula (one drop of 0.12% solution) is nearly 100 times that of latanoprost. Rescula has very little activity on isolated DP or TP receptors, less than 0.0005% the activity of PGE₂ on EP₃ receptors, and about 3% of the activity of PGF_2α on FP receptors.

Chemical Properties

Clear Colourless Oil

Originator

Ueno (Japan)

Uses

Antiglaucoma; used in treatment of ocular hypertension.

Uses

Isopropyl unoprostone is an antiglaucoma,it is used in treatment of ocular hypertension.

Definition

ChEBI: A carboxylic ester that is the isopropyl ester of unoprostone.

brand name

Rescuia

Hazard

A poison.

Isopropyl unoprostone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Isopropyl unoprostone manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Isopropyl unoprostone 120373-24-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-26

Career Henan Chemical Co

Product: Isopropyl unoprostone 120373-24-2
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200KG
Release date: 2019-07-01

120373-24-2, Isopropyl unoprostoneRelated Search:

Ethyl formate 3-Methyl-2-butanone Solvent Red 43 ISOXADIFEN-ETHYL ISOPROPYL LAURATE Trinexapac-ethyl Isopropyl alcohol UNOPROSTONE 2-Ethoxyethanol Ethyl propionate TERT-AMYL METHYL ETHER Isopropyl myristate Propyl acetate Cyclopentyl methyl ether Propyl gallate Ethyl acetate Ethylparaben Ethanol

RESCULA

UNOPROSTONE ISOPROPYL ESTER

isopropyl unoprostone

9ALPHA,11ALPHA-DIHYDROXY-15-OXO-20A,20B-DIHOMOPROST-5-EN-1-OIC ACID, ISOPROPYL ESTER

(5z)-7-((1r,2r,3r,5s)-3,5-dihydroxy-2-(3-oxodecyl)cyclopentyl)-5-heptenoic acid 1-methylethyl ester

(E)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxodecyl)cyclopentyl]-5-heptenoic acid propan-2-yl ester

13,14-dihydro-15-keto-20-ethyl-pgf

13,14-DIHYDRO-15-KETO-20-ETHYL PROSTAGLANDIN F2ALPHA ISOPROPYL ESTER

(5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-(3-oxodecyl)cyclopenthyl]-5-heptenoic Acid Isopropyl Ester

Rescul

UF-021

ISOPROPY UNOPROSTONE

13,14-Dihydro-15-keto-20-ethyl-pgf2

5-Heptenoic acid, 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxodecyl)cyclopentyl)-, 1-methylethyl ester, (5Z)-

Unii-5m161S5o5p

(5Z)-7-[(1R, 2R, 3R, 5S)-3,5-Dihydroxy-2-(3-oxodecyl)cyclopentyl]-5-heptenoic acid

13,14-Dihydro-15-keto-20-ethyl-PGF2 α isopropyl ester

Uroprostaglandin isopropyl ester

13,14-dihydro-15-keto-20-ethyl-PGF2α isopropyl ester, (5Z)-7-[(1R, 2R, 3R, 5S)-3,5-Dihydroxy-2-(3-oxodecyl)cyclopentyl]-5-heptenoic acid

Isopropyl unoprostone USP/EP/BP

120373-24-2

C25H44O5

Prostaglandin

Intermediates & Fine Chemicals

Pharmaceuticals

Prostaglandins

Chiral Reagents