ChemicalBook > CAS DataBase List > Isopropyl unoprostone

Isopropyl unoprostone

Product Name
Isopropyl unoprostone
CAS No.
120373-24-2
Chemical Name
Isopropyl unoprostone
Synonyms
UF-021;Rescul;RESCULA;Unii-5m161S5o5p;ISOPROPY UNOPROSTONE;isopropyl unoprostone;UNOPROSTONE ISOPROPYL ESTER;Isopropyl unoprostone USP/EP/BP;Uroprostaglandin isopropyl ester;13,14-dihydro-15-keto-20-ethyl-pgf
CBNumber
CB1392171
Molecular Formula
C25H44O5
Formula Weight
424.61
MOL File
120373-24-2.mol
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Isopropyl unoprostone Property

Boiling point:
546.3±45.0 °C(Predicted)
Density 
1.019±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly)
form 
Oil
pka
14.79±0.70(Predicted)
color 
Clear Colourless
CAS DataBase Reference
120373-24-2(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H302Harmful if swallowed

H319Causes serious eye irritation

H336May cause drowsiness or dizziness

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16681
Product name
Unoprostone isopropyl ester
Purity
≥98%
Packaging
1mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
16681
Product name
Unoprostone isopropyl ester
Purity
≥98%
Packaging
5mg
Price
$257
Updated
2024/03/01
Cayman Chemical
Product number
16681
Product name
Unoprostone isopropyl ester
Purity
≥98%
Packaging
10mg
Price
$456
Updated
2024/03/01
Cayman Chemical
Product number
16681
Product name
Unoprostone isopropyl ester
Purity
≥98%
Packaging
50mg
Price
$1853
Updated
2024/03/01
TRC
Product number
U800050
Product name
UnoprostoneIsopropylEster
Packaging
5mg
Price
$880
Updated
2021/12/16
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Isopropyl unoprostone Chemical Properties,Usage,Production

Description

Unoprostone isopropyl ester, a novel prostaglandin derivative, was launched in Japan as eye drops for the treatment of glaucoma and ocular hypertension. In animal and human studies, a single drop of unoprostone isopropyl ester induced significant decrease in intraocular pressure without systemic effects, myosis or mydriasis. Unlike prostaglandin analogs such as PGF, unoprostone isopropyl ester does not cause irritation in outer segment of the eye or significant changes in aqueous protein concentration and corneal endothelial permeability. Unoprostone isopropyl ester is suggested to act by increasing uveoscleral outflow or by decreasing episcleral venous pressure, resulting in ocular hypotension.

Description

Unoprostone isopropyl ester (Rescula) is the clinically approved, prodrug form of unoprostone, which is a free acid analog of prostaglandin F (PGF). Both latanoprost and Rescula have been approved for the treatment of ocular hypertension. Both analogs of PGF are believed to act by increasing the rate of aqueous humor outflow through the uveoscleral pathway. Both drugs are believed to act as prodrugs, with endogenous esterases within the eye releasing the free acid active form of the drug. The typical does of Rescula (one drop of 0.12% solution) is nearly 100 times that of latanoprost. Rescula has very little activity on isolated DP or TP receptors, less than 0.0005% the activity of PGE2 on EP3 receptors, and about 3% of the activity of PGF on FP receptors.

Chemical Properties

Clear Colourless Oil

Originator

Ueno (Japan)

Uses

Antiglaucoma; used in treatment of ocular hypertension.

Uses

Isopropyl unoprostone is an antiglaucoma,it is used in treatment of ocular hypertension.

Definition

ChEBI: A carboxylic ester that is the isopropyl ester of unoprostone.

brand name

Rescuia

Hazard

A poison.

Isopropyl unoprostone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Isopropyl unoprostone manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Isopropyl unoprostone 120373-24-2
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-26
Career Henan Chemical Co
Product
Isopropyl unoprostone 120373-24-2
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200KG
Release date
2019-07-01

120373-24-2, Isopropyl unoprostoneRelated Search:


  • RESCULA
  • UNOPROSTONE ISOPROPYL ESTER
  • isopropyl unoprostone
  • 9ALPHA,11ALPHA-DIHYDROXY-15-OXO-20A,20B-DIHOMOPROST-5-EN-1-OIC ACID, ISOPROPYL ESTER
  • (5z)-7-((1r,2r,3r,5s)-3,5-dihydroxy-2-(3-oxodecyl)cyclopentyl)-5-heptenoic acid 1-methylethyl ester
  • (E)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxodecyl)cyclopentyl]-5-heptenoic acid propan-2-yl ester
  • 13,14-dihydro-15-keto-20-ethyl-pgf
  • 13,14-DIHYDRO-15-KETO-20-ETHYL PROSTAGLANDIN F2ALPHA ISOPROPYL ESTER
  • (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-(3-oxodecyl)cyclopenthyl]-5-heptenoic Acid Isopropyl Ester
  • Rescul
  • UF-021
  • ISOPROPY UNOPROSTONE
  • 13,14-Dihydro-15-keto-20-ethyl-pgf2
  • 5-Heptenoic acid, 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxodecyl)cyclopentyl)-, 1-methylethyl ester, (5Z)-
  • Unii-5m161S5o5p
  • (5Z)-7-[(1R, 2R, 3R, 5S)-3,5-Dihydroxy-2-(3-oxodecyl)cyclopentyl]-5-heptenoic acid
  • 13,14-Dihydro-15-keto-20-ethyl-PGF2 α isopropyl ester
  • Uroprostaglandin isopropyl ester
  • 13,14-dihydro-15-keto-20-ethyl-PGF2α isopropyl ester, (5Z)-7-[(1R, 2R, 3R, 5S)-3,5-Dihydroxy-2-(3-oxodecyl)cyclopentyl]-5-heptenoic acid
  • Isopropyl unoprostone USP/EP/BP
  • 120373-24-2
  • C25H44O5
  • Prostaglandin
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Prostaglandins
  • Chiral Reagents