AC-IETD-AFC

Product Name: AC-IETD-AFC
CAS No.: 211990-57-7
Chemical Name: AC-IETD-AFC
Synonyms: AC-IETD-AFC;AC-ILE-GLU-THR-ASP-AFC;Caspase 8 Substrate 1f;CGUOWXRXLQXOKO-FCQBACSVSA-N;M.W. 729.66 C31H38F3N5O12;CASPASE-8 FLUOROGENIC SUBSTRATE;CASPASE 8 SUBSTRATE 1F, FLUOROGENIC;GRANZYME B SUBSTRATE I, COLORIMETRIC;AC-ILE-GLU-THR-ASP-7-AMINO-4-TRIFLUORO-METHYLCOUMARIN;N-ACETYL-ILE-GLU-THR-ASP-(7-AMINO-4-TRIFLUOROMETHYLCOUMARIN)
CBNumber: CB1395556
Molecular Formula: C31H38F3N5O12
Formula Weight: 729.65
MOL File: 211990-57-7.mol

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AC-IETD-AFC Property

Boiling point:: 1113.8±65.0 °C(Predicted)
Density: 1.437±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO
pka: 4.09±0.10(Predicted)
form: Lyophilized powder
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Alfa Aesar

Product number: J64258
Product name: N-Acetyl-Ile-Glu-Thr-Asp-7-amino-4-(trifluoromethyl)coumarin
Packaging: 5mg
Price: $161
Updated: 2021/12/16

Cayman Chemical

Product number: 17480
Product name: Ac-IETD-AFC
Purity: ≥95%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 17480
Product name: Ac-IETD-AFC
Purity: ≥95%
Packaging: 5mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 17480
Product name: Ac-IETD-AFC
Purity: ≥95%
Packaging: 10mg
Price: $321
Updated: 2024/03/01

TRC

Product number: A795613
Product name: Ac-IETD-AFC
Packaging: 5mg
Price: $145
Updated: 2021/12/16

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AC-IETD-AFC Chemical Properties,Usage,Production

Uses

N-Acetyl-Ile-Glu-Thr-Asp-7-amino-4-(trifluoromethyl)coumarin is a fluorogenic substrate for caspases -6, -8, and -10. The IETD sequence is based on the procaspase-3 cleavage site. Residues 172-175 of procaspase-3 are cleaved during apoptosis to produce the p12 subunit and a p20 peptide that is further cleaved to form the p17 subunit of mature caspase 3.

Uses

Ac-IETD-AFC is a fluorogenic substrate for caspase-8/caspase-3 processing enzyme and granzyme B. It is also a substrate for caspase-10. The IETD sequence is based on caspase-3 proenzyme cleavage site.

AC-IETD-AFC Preparation Products And Raw materials

Raw materials

Preparation Products

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AC-IETD-AFC Suppliers

China 58 Germany 2 Japan 1 Switzerland 1 United Kingdom 1 United States 13 Global 76

Tocris Bioscience

Tel: --
Fax: --
Email: customerservice@tocris.co.uk
Country: United Kingdom
ProdList: 5726
Advantage: 77

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View Lastest Price from AC-IETD-AFC manufacturers

Career Henan Chemical Co

Product: AC-IETD-AFC 211990-57-7
Price: US $1.00/g
Min. Order: 1g
Purity: ≥98%
Supply Ability: g/kg/Ton
Release date: 2020-03-05

211990-57-7, AC-IETD-AFCRelated Search:

GRANZYME B AC-IETD-CHO AC-IETD-AFC

CASPASE 8 SUBSTRATE 1F, FLUOROGENIC

CASPASE-8 FLUOROGENIC SUBSTRATE

GRANZYME B SUBSTRATE I, COLORIMETRIC

AC-IETD-AFC

AC-ILE-GLU-THR-ASP-7-AMINO-4-TRIFLUORO-METHYLCOUMARIN

AC-ILE-GLU-THR-ASP-AFC

N-ACETYL-ILE-GLU-THR-ASP-(7-AMINO-4-TRIFLUOROMETHYLCOUMARIN)

N-ACETYL-ILE-GLU-THR-ASP-7-AMINO-4-TRIFLUOROMETHYLCOUMARIN AFC

M.W. 729.66 C31H38F3N5O12

N-Acetyl-L-isoleucyl-L-alpha-glutamyl-L-threonyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-L-alpha-asparagine

CGUOWXRXLQXOKO-FCQBACSVSA-N

Caspase 8 Substrate 1f

L-α-Asparagine, N-acetyl-L-isoleucyl-L-α-glutamyl-L-threonyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-

Ac-IETD-AFC (N-Acetyl-Ile-Glu-Thr-Asp-7-amino-4-Trifluoromethylcoumarin)

211990-57-7

Caspase/Related Products

peptide

Caspases/Apoptosis