ChemicalBook > CAS DataBase List > Boc-N-Me-Val-OH

Boc-N-Me-Val-OH

Product Name
Boc-N-Me-Val-OH
CAS No.
45170-31-8
Chemical Name
Boc-N-Me-Val-OH
Synonyms
Boc-N-me-Val;BOC-N-ME-VAL-OH;Boc-L-N-Me-Val-OH;BOC-MEVAL-OH;BOC-L-MEVAL-OH;BOC-N-ME-VALINE;)amino)-3-methyL;Boc-N-Me-L-Val-OH;N-Boc-N-methylvaline;BOC-N-METHYL-L-VALINE
CBNumber
CB1401257
Molecular Formula
C11H21NO4
Formula Weight
231.29
MOL File
45170-31-8.mol
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Boc-N-Me-Val-OH Property

Melting point:
45-60°C
Boiling point:
322.4±21.0 °C(Predicted)
alpha 
-94 º (c=0.5% in ethanol)
Density 
1.069±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
form 
Solid
pka
4.03±0.10(Predicted)
color 
Off-White
optical activity
[α]20/D 94±3°, c = 0.5% in ethanol
BRN 
2646180
InChI
InChI=1S/C11H21NO4/c1-7(2)8(9(13)14)12(6)10(15)16-11(3,4)5/h7-8H,1-6H3,(H,13,14)/t8-/m0/s1
InChIKey
XPUAXAVJMJDPDH-QMMMGPOBSA-N
SMILES
C(O)(=O)[C@H](C(C)C)N(C(OC(C)(C)C)=O)C
CAS DataBase Reference
45170-31-8(CAS DataBase Reference)
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Safety

WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29225090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.53085
Product name
Boc-N-Me-Val-OH
Purity
Novabiochem?
Packaging
5G
Price
$135
Updated
2024/03/01
Sigma-Aldrich
Product number
15538
Product name
Boc-N-Me-Val-OH
Purity
≥99.0% (TLC)
Packaging
1g
Price
$39.44
Updated
2024/03/01
Alfa Aesar
Product number
H62771
Product name
N-Boc-N-methyl-L-valine, 95%
Packaging
1g
Price
$68.65
Updated
2024/03/01
Alfa Aesar
Product number
H62771
Product name
N-Boc-N-methyl-L-valine, 95%
Packaging
5g
Price
$292.65
Updated
2024/03/01
TRC
Product number
B201920
Product name
N-Boc-N-methyl-L-valine
Packaging
1g
Price
$45
Updated
2021/12/16
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Boc-N-Me-Val-OH Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

N-Boc-N-methyl-L-valine (Boc-N-Me-Val-OH) is an amino acid derived compound that functions as a useful pharmaceutical intermediate and also employed as a reagent used in organic synthesis. It is used in the synthesis of lactam analog of actinomycin D, a potential antitumor chemotherapeutic agent. It is also used to N-tert-Butoxycarbonyl-N-methyl-L-valine 4-ethynylanilide with 4-ethynylaniline[1].

Synthesis

To a solution of N-BOC-valine 1 (217 mg, 1 mmol) and iodomethane(1.42 g, 10 mmol) in anhydrous tetrahydrofuran (THF,20 mL) was added neat sodium hydride (240 mg, 10 mmol). The reaction mixture was stirred at room temperature for 24 hours. The mixture was then quenched with water (30 mL). The reaction mixture was extracted with ethyl acetate (EtOAc, 2 15 mL) and the aqueous solution was acidified to pH 3, after which it was extracted with EtOAc (3 20 mL). The combined organic phase was dried over anhydrous Na2SO4 and evaporated to afford the corresponding Boc-N-Me-Val-OH (thick colorless oil), 99% yield.

References

[1] Masashi Shiotsuki. “Molecular weight dependence of helical conformation of amino acid-based polyphenylacetylenes.” Journal of Polymer Science Part A: Polymer Chemistry 49 22 (2011): 4921–4925.

Boc-N-Me-Val-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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Boc-N-Me-Val-OH Suppliers

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View Lastest Price from Boc-N-Me-Val-OH manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Boc-N-Me-Val-OH 45170-31-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2023-09-27
Zibo Hangyu Biotechnology Development Co., Ltd
Product
Boc-N-Me-Val-OH 45170-31-8
Price
US $65.00-650.00/KG
Min. Order
1KG
Purity
0.99
Supply Ability
20 tons
Release date
2023-10-25
Shanghai Getian Industrial Co., LTD
Product
Boc-N-Me-Val-OH 45170-31-8
Price
US $28.00/box
Min. Order
1box
Purity
99%
Supply Ability
20000box
Release date
2024-06-03

45170-31-8, Boc-N-Me-Val-OHRelated Search:

Thiophanate-methyl Methylparaben Bensulfuron methyl N-Carbobenzyloxyglycine Kresoxim-methyl Boc-Aib-OH Sodium carboxymethyl cellulose N-Methyl-2-pyrrolidone 1-Methylimidazole 1-Methylpyrrolidine L-Valine Methyl acrylate N,N-Dimethylformamide PYRAZOPHOS N-Boc-L-valine Valine CARBONYL SULFIDE Methyl

  • BOC-N-METHYL-L-VAL-OH
  • Boc-N-me-Val
  • N-ALPHA-TERT-BUTYLOXYCABONYL-N-ALPHA-METHYL-L-VALINE
  • NALPHA-tert-Butoxycarbonyl-N-methyl-L-valine
  • N-[(tert-Butoxy)carbonyl]-N-methyl-L-valine
  • Boc-L-N-Me-Val-OH
  • (S)-2-((tert-Butoxycarbonyl)(Methyl)aMino)-3-Methylbutanoic acid
  • Boc-N-Me-Val-OH >=99.0% (TLC)
  • Boc-N-Me-L-Val-OH
  • (2S)-2-[[(tert-Butoxy)carbonyl](methyl)amino]-3-methylbutanoic acid
  • BOC-N-METHYL-L-VALINE
  • BOC-N-ME-VALINE
  • BOC-N-ME-VAL-OH
  • BOC-MEVAL-OH
  • BOC-N-ALPHA-METHYL-L-VALINE
  • BOC-L-MEVAL-OH
  • N-ALPHA-T-BOC-N-ALPHA-METHYL-L-VALINE
  • N-ALPHA-T-BUTOXYCARBONYL-N-ALPHA-METHYL-L-VALINE
  • N-ALPHA-T-BUTYLOXYCARBONYL-N-ALPHA-METHYL-L-VALINE
  • N-ALPHA-TERT-BUTYLOXYCARBONYL-N-ALPHA-METHYL-L-VALINE
  • N-BOC-N-METHYL-(L)-VALINE
  • Boc-N-methyl-L-valine≥ 99% (TLC)
  • (Tert-Butoxy)Carbonyl N-Me-Val-OH (Syrup)
  • N-(tert-Butoxycarbonyl)-N-methyl-L-valine&gt
  • (S)-2-((tert-ButoxycarbonyL
  • )amino)-3-methyL
  • L-Valine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-
  • (2S)-3-methyl-2-[methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]butanoicaci
  • Boc-N-methyl-L-valine USP/EP/BP
  • N-Boc-N-methylvaline
  • Boc-N-α-Methyl-L-valine
  • Entecavir Impurity 133
  • 45170-31-8
  • N-Methyl Amino Acids
  • Peptide Synthesis
  • Unnatural Amino Acid Derivatives
  • Specialty Synthesis
  • amino acids
  • Valine [Val, V]
  • N-Methyl Amino Acids
  • Boc-Amino acid series