Pinacol

ChemicalBook > CAS DataBase List > Pinacol

Product Name: Pinacol
CAS No.: 76-09-5
Chemical Name: Pinacol
Synonyms: 2,3-Dimethylbutane-2,3-diol;2,3-DIMETHYL-2,3-BUTANEDIOL;PINACONE;Pinakol;PINACOL ANHYDROUS;Picol;PINACOL;Pinacol,99%;Pinacol 98%;Pinacol >
CBNumber: CB1403084
Molecular Formula: C6H14O2
Formula Weight: 118.17
MOL File: 76-09-5.mol

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Pinacol Property

Melting point:: 40-43 °C (lit.)
Boiling point:: 171-172 °C/739 mmHg (lit.)
Density: 0.967 g/cm3 (20℃)
refractive index: 1.4347 (estimate)
Flash point:: 171 °F
storage temp.: Inert atmosphere,Room Temperature
solubility: alcohol: freely soluble
pka: 14.80±0.29(Predicted)
form: Crystalline Low Melting Solid
color: White
Odor: at 100.00 %. woody earthy patchouli warm bread
Odor Type: woody
Water Solubility: Soluble in hot water, alcohol, and diethyl ether.
Sensitive: Hygroscopic
Merck: 14,7439
BRN: 1340501
Dielectric constant: 7.4（24℃）
Stability:: Stable. Combustible. Incompatible with strong oxidizing agents, strong bases, strong acids.
InChIKey: IVDFJHOHABJVEH-UHFFFAOYSA-N
LogP: 0.540
CAS DataBase Reference: 76-09-5(CAS DataBase Reference)
NIST Chemistry Reference: 2,3-Butanediol, 2,3-dimethyl-(76-09-5)
EPA Substance Registry System: 2,3-Butanediol, 2,3-dimethyl- (76-09-5)

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Safety

Hazard Codes: Xi,F
Risk Statements: 38-36/37/38-11
Safety Statements: 37-37/39-26
WGK Germany: 2
RTECS: EK1720000
F: 3
TSCA: Yes
HS Code: 29053990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H303May be harmfulif swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H320Causes eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 221171
Product name: Pinacol
Purity: 98%
Packaging: 5g
Price: $36.06
Updated: 2024/03/01

Sigma-Aldrich

Product number: 221171
Product name: Pinacol
Purity: 98%
Packaging: 100g
Price: $176
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.21032
Product name: Pinacol
Purity: for synthesis
Packaging: 100g
Price: $136
Updated: 2023/01/07

TCI Chemical

Product number: D0691
Product name: Pinacol
Purity: >98.0%(GC)
Packaging: 25g
Price: $40
Updated: 2024/03/01

TCI Chemical

Product number: D0691
Product name: Pinacol
Purity: >98.0%(GC)
Packaging: 100g
Price: $80
Updated: 2024/03/01

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Pinacol Chemical Properties,Usage,Production

Chemical Properties

white solid

Occurrence

Has apparently not been reported to occur in nature.

Uses

pinacol be used as organic intermediates.
The pinacol coupling reaction with the inorganic electride [Ca2N](+)·e(−) as an electron donor in organic solvents was studied.
Pinacol is used in the synthesis of organic reagents such as alkenylphenylphosphonates and alkenylboronates.

Uses

Pinacol is used in the preparation of synthetic intermediates like pinacolborane, bis(pinacolato)diboron and pinacolchloroborane by reaction with boron trichloride. Further, it plays an important role as an intermediate for biologically active compounds like antiviral, antibacterial, antifungal and antituberculous.

Preparation

By the bimolecular reduction of acetone.

Definition

ChEBI: A glycol that is ethylene glycol in which all four methylene hydrogens have been replaced by methyl groups.

Synthesis Reference(s)

Chemistry Letters, 10, p. 1469, 1981
Journal of the American Chemical Society, 98, p. 1986, 1976 DOI: 10.1021/ja00423a067
Tetrahedron Letters, 21, p. 449, 1980 DOI: 10.1016/S0040-4039(00)71429-8

Toxicity evaluation

Both the acute oral LD₅₀ value in rats and the acute dermal LD₅₀ value in rabbits exceeded 5 g/kg (Moreno, 1975). The acute oral LD₅₀ of pinacol for male albino mice was found to be 28-6 mmol/kg (Wenzel & Koff, 1956). Pinacol showed anticonvulsant activity for electroshock seizures and Metrazol? convulsions; the PD 50 values (a measure of the protective dose) determined 15 min after oral administration of pinacol to mice were found to be 16-4 and 3-44 mmol/kg for electroshock and Metrazol convulsions, respectively (Wenzel & Koff, 1956).

General Description

The pinacol coupling reaction with the inorganic electride [Ca₂N](+)·e(?) as an electron donor in organic solvents was studied.

Metabolism

Pinacol forms a glucuronide in the rabbit (Williams, 1959), and was found highly conjugated with glucuronic acid in the urine of chinchilla rabbits following oral administration of 1.0-1.5 g pinacol/kg body weight (Gessner, Parke & Williams, 1960). Pinacol was not utilized to any significant extent by endocrine tissues from human placenta, rat ovary, rat testis or rat adrenal gland (Ferguson, Baillie, Caiman & Hart, 1966).

Purification Methods

The hydrate is rendered anhydrous by azeotropic distillation of water with *benzene. Recrystallise it from *benzene or toluene/pet ether, absolute EtOH or dry diethyl ether. It recrystallises from water to give the hexahydrate. [Beilstein 1 IV 2575.]

Pinacol Preparation Products And Raw materials

Raw materials

Mercury chloride

Preparation Products

2-(2-ISOPROPYLPHENYL)-4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE 1-Methyl-4-pyrazole boronic acid pinacol ester 4-((N,N-DIMETHYLAMINO)METHYL)PHENYLBORONIC ACID PINACOL ESTER HYDROCHLORIDE Isopropenylboronic acid pinacol ester 4-Carboxylphenylboronic acid pinacol ester 2-[3-(2-FURYL)PHENYL]-4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE 4-SULFAMOYLPHENYLBORONIC ACID, PINACOL ESTER Bis(pinacolato)diboron Pinacolone 2,3-DIMETHYL-1,3-BUTADIENE 5-AMINOPYRIDINE-2-BORONIC ACID PINACOL ESTER 2-(1-FLUORONAPHTHALEN-4-YL)-4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE 2-(1-BENZOTHIOPHEN-5-YL)-4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE 3-MORPHOLINOPHENYLBORONIC ACID PINACOL ESTER Pinacolborane 4-(PYRROLIDIN-1-YLMETHYL)BENZENEBORONIC ACID, PINACOL ESTER 97%1-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZYL]PYRROLIDINE 1-Methyl-1H-pyrazole-5-boronic acid pinacol ester

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View Lastest Price from Pinacol manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Pinacol 76-09-5
Price: US $45.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2024-11-15

Hebei Weibang Biotechnology Co., Ltd

Product: Pinacol 76-09-5
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-01

Hebei Mojin Biotechnology Co., Ltd

Product: Pinacol 76-09-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-09-06

76-09-5, PinacolRelated Search:

Ethylene glycol diacetate Pinacolone 1-Phenyl-1,2-ethanediol Dimethyl carbonate 2-Methyl-2,4-pentanediol 2-Butyne-1,4-diol Dimethyl fumarate Triethylene glycol DOWANOL(TM) PNB Diethylene glycol Polyethylene Glycol Dimethyl ether ETHYLENE GLYCOL DISTEARATE Benzopinacole Dimethyl sulfoxide FARNESOL N,N-Dimethylformamide ETHANE

2,3-Dimethylbutane-2,3-diol

2,3-DIMETHYL-2,3-BUTANEDIOL

TETRAMETHYLETHYLENE GLYCOL

PINACOL

PINACONE

2,3-DIMETHYLBUTANEDIOL-2,3

Pinakol

PINACOL pure

2,3-Dimethyl-2,3-butanediol, Tetramethylethylene glycol

2,3-Dimethyl-2,3-butanediol (Pinacol)

Pinacol,2,3-Dimethyl-2,3-butanediol, Tetramethylethylene glycol

Frequency that alcohol

TetraMethyl glycol

Pinacol, 99% 100GR

Pinacol,99%

2,3-Dimethyl-2,3-butanediol Pinacone Tetramethylethylene Glycol

Pinacol, 97+%

Pinacol 98%

Tetramethylethylene glycol, Pinacol

Picol

1,1,2,2-tetramethylethyleneglycol

2,3-butanediol,2,3-dimethyl-

2,3-Dihydroxy-2,3-dimethylbutane

2,3-Dimethyl-2,3-dihydroxybutane

2,3-dimethyl-3-butanediol

Dimethyl-4-butyleneglycol

meso-2,3-Dimethyl-2,3-butanediol

PINACOL ANHYDROUS

Pinacol(2,3-Dimethyl-2,3-Butanediol)

Pinacol &gt

pinacol 2,3-dimethylbutane-2,3-diol

TIANFU CHEM - Pinacol

76-09-5

1976-09-05

1976-9-5

1976-09-5

HOCCH32CCH32OH

C6H14O26H2O

CH32COHCOHCH32

CH32COH2

Oxygen Compounds

Polyols

Organic Building Blocks

Building Blocks

Acetone series

76-09-5