Pharmacological effects Chemical Properties Uses Production method
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Naphazoline hydrochloride

Pharmacological effects Chemical Properties Uses Production method
Product Name
Naphazoline hydrochloride
CAS No.
550-99-2
Chemical Name
Naphazoline hydrochloride
Synonyms
NAPHAZOLINE HCL;Naphazoline hydrochloride (Naphcon);4,5-DIHYDRO-2-(1-NAPHTHYLMETHYL)-1H-IMIDAZOLE HYDROCHLORIDE;clera;niazol;coldan;naphcon;rhinoperd;rhinantin;stricylon
CBNumber
CB1412136
Molecular Formula
C14H14N2.ClH
Formula Weight
246.74
MOL File
550-99-2.mol
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Naphazoline hydrochloride Property

Melting point:
254-260 °C
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Freely soluble in water, soluble in ethanol (96 per cent).
pka
pKa (25°C) 10.35 ±0.02, (35°C) 10.13 ±0.02, (45°C) 9.92 ±0.03; pKa (25°C) 10.35 ±0.02, (35°C) 10.13 ±0.02, (45°C) 9.92 ±0.03
form 
Crystalline Powder
color 
White
PH
pH (50g/l, 25℃) : 4.0～6.0
Water Solubility 
170 g/L (20 ºC)
Sensitive 
Hygroscopic
Merck 
14,6368
BRN 
3716843
Stability:
Hygroscopic
InChIKey
DJDFFEBSKJCGHC-UHFFFAOYSA-N
CAS DataBase Reference
550-99-2(CAS DataBase Reference)
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Safety

Hazard Codes 
T,Xn
Risk Statements 
25-23/24/25-20/21/22
Safety Statements 
45-36/37/39-24/25
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
3
RTECS 
NJ4375000
HazardClass 
6.1
PackingGroup 
III
HS Code 
29339900
Hazardous Substances Data
550-99-2(Hazardous Substances Data)
Toxicity
LD50 s.c. in rats: 385 mg/kg (Gylfe)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P321Specific treatment (see … on this label).

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
N5504
Product name
Naphazoline hydrochloride
Packaging
25g
Price
$72.3
Updated
2024/03/01
Sigma-Aldrich
Product number
1457006
Product name
Naphazoline hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$436
Updated
2024/03/01
TCI Chemical
Product number
N0542
Product name
Naphazoline Hydrochloride
Purity
>99.0%(T)
Packaging
10g
Price
$25
Updated
2024/03/01
Alfa Aesar
Product number
B24161
Product name
2-(1-Naphthylmethyl)-2-imidazoline hydrochloride, 99%
Packaging
25g
Price
$32.65
Updated
2024/03/01
Alfa Aesar
Product number
B24161
Product name
2-(1-Naphthylmethyl)-2-imidazoline hydrochloride, 99%
Packaging
100g
Price
$81.65
Updated
2024/03/01
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Naphazoline hydrochloride Chemical Properties,Usage,Production

Pharmacological effects

Naphazoline hydrochloride, is commonly used as a vasoconstrictor in the hospital's otorhinolaryngology and ophthalmology ,it is a adrenomimetic drug ,it has a strong effect on contraction of blood vessels and blood pressure elevation,it has inhibition effect on the central nervous system,by contraction of local vascular, it can play an anti-inflammatory and analgesic role in the local inflammatory lesions , and can eliminate congestion due to fatigue or other reasons. Clinically it is used for the treatment of colds, acute and chronic rhinitis, allergic conjunctivitis, allergic and inflammatory nasal congestion embolism. Local long-term use can lead to blood flow reduction in medication area, which causes resistance decreasing , and results in superinfection. It can not be taken orally. Dropping excess liquid or high concentrations can cause poisoning. Care should be taken, especially in children. Infants, hypertension, hyperthyroidism patients should take with caution, atrophic rhinitis patients are banned. The interval time of dropping , is preferably not less than 4 to 6 hours.
The above information is edited by the chemicalbook of Tian Ye.

Chemical Properties

White crystalline powder. Melting point 255-260 ℃. 40 grams of the product can be dissolved in 100 ml of water . It is soluble in alcohol, slightly soluble in chloroform, insoluble in ether and benzene. Odorless, bitter taste.

Uses

This product is a vasoconstrictor. Rat subcutaneous injection is LD50 385 mg/kg.

Production method

By the α-naphthalene acetic acid and ethylene diamine condensation, cyclization ,2-(1-naphthylmethyl) imidazoline (C14H14N2, [835-31-4]) is made , then after salifying, naphazoline hydrochloride is derived . The α-acetic acid and ethylene diamine are added to the reaction pot, stir and heat to 120 ℃, react after 1 hour, then heat to 130 ℃, react for 1 hour. Ethylenediamine and water are distilled ,and after vacuum distillation, collect 180-240 ℃ (1.33-4 kPa) distillate, obtain 2-(1-naphthylmethyl) imidazoline. It is dissolved in a mixture of acetone and ethanol, and at 10-12℃ inlet hydrogen chloride gas to become into a salt, naphazoline hydrochloride crystals is generated .

Chemical Properties

White or almost white, crystalline powder.

Originator

Albalon,Allergan,Australia

Uses

Naphazoline Hydrochloride is a useful synthetic intermediate used in eye drops. A vasoconstrictor.

Uses

adrenergic blocker

Uses

antihistamine

Definition

ChEBI: Naphazoline is an organic molecular entity.

Manufacturing Process

2.7 parts of naphtyl-(1)-acetiminoethylether (produced from naphthyl-1- acetonitrile) were dissolved in 12 parts of absolute alcohol. 1 part of ethylenediamine is then added and the mixture was heated to gentle boiling while passing it through nitrogen and simultaneously stirring until ammonia escaped no longer. The alcohol was is then distilled and the residue mixed with 40 parts of benzene and 1.8 parts of caustic potash. Stirring was continued for some time whereby the imidazoline base was dissolved in benzene. The benzene residue, is recrystallized several times from toluene. The 2-[naphthyl-1-methyl]-imidazoline represented the coloriless crystalls of melting point 252°-253°C. Its hydrochloride is easily soluble in water.

brand name

Albalon (Allergan); Nafazair (Bausch & Lomb); Nafazair (Pharmafair); Naphcon (Alcon); Opcon (Bausch & Lomb); Vasocon (Novartis).

Therapeutic Function

Vasoconstrictor, Nasal decongestant

Naphazoline hydrochloride Preparation Products And Raw materials

Raw materials

1-Methylimidazole 1-Naphthaleneacetic acid Imidazolidine

Preparation Products

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View Lastest Price from Naphazoline hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Naphazoline hydrochloride 550-99-2
Price
US $1.00/KG
Min. Order
1KG
Purity
99.00%-101.00%,USP/BP
Supply Ability
1ton/month
Release date
2021-06-16
Hebei Weibang Biotechnology Co., Ltd
Product
Naphazoline hydrochloride 550-99-2
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-31
Hebei Yanxi Chemical Co., Ltd.
Product
Naphazoline hydrochloride 550-99-2
Price
US $20.00-1.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
30 tons
Release date
2023-11-03

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