ChemicalBook > CAS DataBase List > 1-Bromo-4-(trifluoromethoxy)benzene

1-Bromo-4-(trifluoromethoxy)benzene

Product Name
1-Bromo-4-(trifluoromethoxy)benzene
CAS No.
407-14-7
Chemical Name
1-Bromo-4-(trifluoromethoxy)benzene
Synonyms
4-Bromozbenzotrifluoride;P-BROMOTRIFLUOROMETHOXYBENZENE;4-(TRIFLUOROMETHOXY)BROMOBENZENE;1-Bromo-4-(trifL;TIMTEC-BB SBB006606;1-Bromo-4-(trifluoro;Benzene, 1-bromo-4-(trifluo;P-Bromotrifluoromethoxybenzen;1-Bromo-4-(Trifluoromethoxy)Be;P-TRIFLUOROMETHOXY BROMOBENZENE
CBNumber
CB1413764
Molecular Formula
C7H4BrF3O
Formula Weight
241.01
MOL File
407-14-7.mol
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1-Bromo-4-(trifluoromethoxy)benzene Property

Boiling point:
80 °C50 mm Hg(lit.)
Density 
1.622 g/mL at 25 °C(lit.)
vapor pressure 
20 hPa (55 °C)
refractive index 
n20/D 1.461(lit.)
Flash point:
154 °F
storage temp. 
Sealed in dry,Room Temperature
solubility 
11.7mg/l
form 
Liquid
Specific Gravity
1.64
color 
Clear colorless to yellow
Water Solubility 
11.7mg/L
BRN 
2046332
InChI
InChI=1S/C7H4BrF3O/c8-5-1-3-6(4-2-5)12-7(9,10)11/h1-4H
InChIKey
SEAOBYFQWJFORM-UHFFFAOYSA-N
SMILES
C1(Br)=CC=C(OC(F)(F)F)C=C1
CAS DataBase Reference
407-14-7(CAS DataBase Reference)
NIST Chemistry Reference
P-bromophenyl trifluoromethyl ether(407-14-7)
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Safety

Hazard Codes 
Xn,N,Xi
Risk Statements 
22-36/37/38-43-51/53
Safety Statements 
26-36/37-61-37/39-36
RIDADR 
UN 3082 9/PG 3
WGK Germany 
1
HazardClass 
IRRITANT
HS Code 
29093090
Toxicity
LD50 orally in Rabbit: > 2500 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
339601
Product name
1-Bromo-4-(trifluoromethoxy)benzene
Purity
99%
Packaging
5g
Price
$25.46
Updated
2025/07/31
Sigma-Aldrich
Product number
8.14964
Product name
1-Bromo-4-(trifluoromethoxy)benzene
Purity
for synthesis
Packaging
50mL
Price
$184
Updated
2023/01/07
TCI Chemical
Product number
B1772
Product name
1-Bromo-4-(trifluoromethoxy)benzene
Purity
>98.0%(GC)
Packaging
5g
Price
$20
Updated
2025/07/31
TCI Chemical
Product number
B1772
Product name
1-Bromo-4-(trifluoromethoxy)benzene
Purity
>98.0%(GC)
Packaging
25g
Price
$49
Updated
2025/07/31
TRC
Product number
B695178
Product name
1-Bromo-4-(trifluoromethoxy)benzene
Packaging
1g
Price
$55
Updated
2021/12/16
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1-Bromo-4-(trifluoromethoxy)benzene Chemical Properties,Usage,Production

Chemical Properties

CLEAR COLOURLESS TO YELLOW LIQUID

Uses

1-Bromo-4-(trifluoromethoxy)benzene was used in the synthesis of 4-{[4-[(2-ethylhexyloxy)-6-(4-morpholinylmethyl)-4-trifluoromethyl][1,1-biphenyl]-3-yl]methyl}morpholine.

Synthesis Reference(s)

Journal of the American Chemical Society, 109, p. 3708, 1987 DOI: 10.1021/ja00246a030

General Description

1-Bromo-4-(trifluoromethoxy)benzene on treatment with lithium diisopropylamide (LIDA) at -100°C gives 5-bromo-2-(trifluoromethoxy)phenyllithium and at -75°C it eliminates lithium bromide, thus generating 1,2-dehydro-4-(trifluoromethoxy)benzene.

Synthesis

143582-87-0

407-14-7

GENERAL METHOD: To a solution of dichloroethane (2 mL) containing IF5-pyridine-HF (321 mg, 1.0 mmol), Et3N-6HF (553 mg, 2.5 mmol) and 2a (113 mg, 0.5 mmol) were sequentially added at room temperature. The reaction mixture was stirred at 60 °C for 9 hours. Upon completion of the reaction, the dark red solution was poured into water (20 mL) and extracted with dichloromethane (20 mL x 3). The organic layers were combined, washed sequentially with aqueous NaHCO3 and aqueous Na2S2O3, and dried over MgSO4. The yield of 4a was determined to be 74% by 19F NMR using fluorobenzene as an internal standard. Purification by column chromatography (silica gel/hexane) afforded 4a. IR (pure) 2963, 1256, 1212 cm-1; 1H NMR δ 7.23 (d, J = 8.8 Hz, 2H), 7.13 (d, J = 8.4 Hz, 2H), 2.95-2.85 (m, 1H), 1.24 (d, J = 6.8 Hz, 6H); 19F NMR δ -58.53 (s, 3F); 13C NMR δ 147.7, 147.3, 127.8 (2C), 121.0 (2C), 120.7 (q, 1JC-F = 257.7 Hz), 33.7, 24.1 (2C); HRMS (EI) calculated value C10H11F3O 204.07620, measured value 204.07606.

References

[1] Tetrahedron Letters, 1992, vol. 33, # 29, p. 4173 - 4176
[2] Bulletin of the Chemical Society of Japan, 2000, vol. 73, # 2, p. 471 - 484
[3] Journal of Fluorine Chemistry, 2015, vol. 179, p. 48 - 52
[4] Patent: US2015/315136, 2015, A1. Location in patent: Paragraph 0132; 0137; 0138

1-Bromo-4-(trifluoromethoxy)benzene Preparation Products And Raw materials

Raw materials

Bromobenzene

Preparation Products

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1-Bromo-4-(trifluoromethoxy)benzene Suppliers

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View Lastest Price from 1-Bromo-4-(trifluoromethoxy)benzene manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
1-Bromo-4-(trifluoromethoxy)benzene 407-14-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2024-12-04
Henan Aochuang Chemical Co.,Ltd.
Product
1-Bromo-4-(trifluoromethoxy)benzene 407-14-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-08
Shaanxi Dideu New Materials Co. Ltd
Product
1-Bromo-4-(trifluoromethoxy)benzene 407-14-7
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-02-22

407-14-7, 1-Bromo-4-(trifluoromethoxy)benzeneRelated Search:

4-(Trifluoromethoxy)aniline o-Anisaldehyde 4-Methoxybenzyl cyanide 4-(Trifluoromethoxy)benzaldehyde 3-(Trifluoromethoxy)aniline Xylene 2-(Trifluoromethoxy)aniline p-Anisaldehyde m-Anisyl alcohol 4-(Trifluoromethoxy)chlorobenzene 4-Methoxybenzoic acid p-Trifluoromethoxy phenol 4'-(Trifluoromethoxy)acetophenone 3-Methoxybenzaldehyde Anisole 4-Methoxyphenylacetic acid (Trifluoromethoxy)benzene Benzene

  • 4-BROMO-ALPHA,ALPHA,ALPHA-TRIFLUOROANISOLE
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  • 1-Bromo-4-(trifluoromethoxy)benzene,98%
  • Benzene, 1-bromo-4-(trifluo
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  • BroMo (trifluoroMethoxy) benzene
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  • 1-BROMO-4-(TRIFLUOROMETHOXY)BENZENE FOR
  • 1-Bromo-4-(trifluoromethoxy)benzene 98%
  • 4-Bromophenyl trifluoromethyl ether, 4-Bromo-alpha,alpha,alpha-trifluoroanisole
  • 1-BroMo-4-(trifluoroMethoxy)benzene, 97+%
  • For trifluoromethoxybromobenzene
  • The broMine trifluoro Methoxy benzene
  • 4-BroMo-1-(trifluoroMethoxy)benzene
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  • 407-14-7
  • C7H4BrOF3
  • BrC6H4OCF3
  • Building Blocks for Liquid Crystals
  • Chalcones, etc. (Building Blocks for Liquid Crystals)
  • Ethers
  • Organic Building Blocks
  • Oxygen Compounds
  • Building Blocks
  • Ethers
  • Organic Building Blocks
  • Oxygen Compounds
  • Fluorobenzene
  • Aromatic Halides (substituted)
  • Trifluoromethoxybenzene Series
  • Miscellaneous
  • Anisoles, Alkyloxy Compounds & Phenylacetates
  • Bromine Compounds
  • Fluorine Compounds
  • Building Blocks for Liquid Crystals
  • Chalcones, etc. (Building Blocks for Liquid Crystals)
  • Functional Materials