1-Bromo-4-(trifluoromethoxy)benzene
- Product Name
- 1-Bromo-4-(trifluoromethoxy)benzene
- CAS No.
- 407-14-7
- Chemical Name
- 1-Bromo-4-(trifluoromethoxy)benzene
- Synonyms
- 4-Bromozbenzotrifluoride;P-BROMOTRIFLUOROMETHOXYBENZENE;4-(TRIFLUOROMETHOXY)BROMOBENZENE;1-Bromo-4-(trifL;TIMTEC-BB SBB006606;1-Bromo-4-(trifluoro;Benzene, 1-bromo-4-(trifluo;P-Bromotrifluoromethoxybenzen;1-Bromo-4-(Trifluoromethoxy)Be;P-TRIFLUOROMETHOXY BROMOBENZENE
- CBNumber
- CB1413764
- Molecular Formula
- C7H4BrF3O
- Formula Weight
- 241.01
- MOL File
- 407-14-7.mol
1-Bromo-4-(trifluoromethoxy)benzene Property
- Boiling point:
- 80 °C50 mm Hg(lit.)
- Density
- 1.622 g/mL at 25 °C(lit.)
- vapor pressure
- 20 hPa (55 °C)
- refractive index
- n20/D 1.461(lit.)
- Flash point:
- 154 °F
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- 11.7mg/l
- form
- Liquid
- Specific Gravity
- 1.64
- color
- Clear colorless to yellow
- Water Solubility
- 11.7mg/L
- BRN
- 2046332
- InChI
- InChI=1S/C7H4BrF3O/c8-5-1-3-6(4-2-5)12-7(9,10)11/h1-4H
- InChIKey
- SEAOBYFQWJFORM-UHFFFAOYSA-N
- SMILES
- C1(Br)=CC=C(OC(F)(F)F)C=C1
- CAS DataBase Reference
- 407-14-7(CAS DataBase Reference)
- NIST Chemistry Reference
- P-bromophenyl trifluoromethyl ether(407-14-7)
Safety
- Hazard Codes
- Xn,N,Xi
- Risk Statements
- 22-36/37/38-43-51/53
- Safety Statements
- 26-36/37-61-37/39-36
- RIDADR
- UN 3082 9/PG 3
- WGK Germany
- 1
- HazardClass
- IRRITANT
- HS Code
- 29093090
- Toxicity
- LD50 orally in Rabbit: > 2500 mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 339601
- Product name
- 1-Bromo-4-(trifluoromethoxy)benzene
- Purity
- 99%
- Packaging
- 5g
- Price
- $25.46
- Updated
- 2025/07/31
- Product number
- 8.14964
- Product name
- 1-Bromo-4-(trifluoromethoxy)benzene
- Purity
- for synthesis
- Packaging
- 50mL
- Price
- $184
- Updated
- 2023/01/07
- Product number
- B1772
- Product name
- 1-Bromo-4-(trifluoromethoxy)benzene
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $20
- Updated
- 2025/07/31
- Product number
- B1772
- Product name
- 1-Bromo-4-(trifluoromethoxy)benzene
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $49
- Updated
- 2025/07/31
- Product number
- B695178
- Product name
- 1-Bromo-4-(trifluoromethoxy)benzene
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
1-Bromo-4-(trifluoromethoxy)benzene Chemical Properties,Usage,Production
Chemical Properties
CLEAR COLOURLESS TO YELLOW LIQUID
Uses
1-Bromo-4-(trifluoromethoxy)benzene was used in the synthesis of 4-{[4-[(2-ethylhexyloxy)-6-(4-morpholinylmethyl)-4-trifluoromethyl][1,1-biphenyl]-3-yl]methyl}morpholine.
Synthesis Reference(s)
Journal of the American Chemical Society, 109, p. 3708, 1987 DOI: 10.1021/ja00246a030
General Description
1-Bromo-4-(trifluoromethoxy)benzene on treatment with lithium diisopropylamide (LIDA) at -100°C gives 5-bromo-2-(trifluoromethoxy)phenyllithium and at -75°C it eliminates lithium bromide, thus generating 1,2-dehydro-4-(trifluoromethoxy)benzene.
Synthesis
143582-87-0
407-14-7
GENERAL METHOD: To a solution of dichloroethane (2 mL) containing IF5-pyridine-HF (321 mg, 1.0 mmol), Et3N-6HF (553 mg, 2.5 mmol) and 2a (113 mg, 0.5 mmol) were sequentially added at room temperature. The reaction mixture was stirred at 60 °C for 9 hours. Upon completion of the reaction, the dark red solution was poured into water (20 mL) and extracted with dichloromethane (20 mL x 3). The organic layers were combined, washed sequentially with aqueous NaHCO3 and aqueous Na2S2O3, and dried over MgSO4. The yield of 4a was determined to be 74% by 19F NMR using fluorobenzene as an internal standard. Purification by column chromatography (silica gel/hexane) afforded 4a. IR (pure) 2963, 1256, 1212 cm-1; 1H NMR δ 7.23 (d, J = 8.8 Hz, 2H), 7.13 (d, J = 8.4 Hz, 2H), 2.95-2.85 (m, 1H), 1.24 (d, J = 6.8 Hz, 6H); 19F NMR δ -58.53 (s, 3F); 13C NMR δ 147.7, 147.3, 127.8 (2C), 121.0 (2C), 120.7 (q, 1JC-F = 257.7 Hz), 33.7, 24.1 (2C); HRMS (EI) calculated value C10H11F3O 204.07620, measured value 204.07606.
References
[1] Tetrahedron Letters, 1992, vol. 33, # 29, p. 4173 - 4176
[2] Bulletin of the Chemical Society of Japan, 2000, vol. 73, # 2, p. 471 - 484
[3] Journal of Fluorine Chemistry, 2015, vol. 179, p. 48 - 52
[4] Patent: US2015/315136, 2015, A1. Location in patent: Paragraph 0132; 0137; 0138
1-Bromo-4-(trifluoromethoxy)benzene Preparation Products And Raw materials
Raw materials
Preparation Products
1-Bromo-4-(trifluoromethoxy)benzene Suppliers
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View Lastest Price from 1-Bromo-4-(trifluoromethoxy)benzene manufacturers
- Product
- 1-Bromo-4-(trifluoromethoxy)benzene 407-14-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-12-04
- Product
- 1-Bromo-4-(trifluoromethoxy)benzene 407-14-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-08
- Product
- 1-Bromo-4-(trifluoromethoxy)benzene 407-14-7
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-02-22