ChemicalBook > CAS DataBase List > 6-Mercaptopurine

6-Mercaptopurine

Product Name
6-Mercaptopurine
CAS No.
50-44-2
Chemical Name
6-Mercaptopurine
Synonyms
6mp;THIOPURINE;mercaptopurin;purinethol;7H-PURINE-6-THIOL;Azathioprine EP Impurity B;3,7-dihydro-6H-purine-6-thione;mern;nsc755;u-4748
CBNumber
CB1425059
Molecular Formula
C5H4N4S
Formula Weight
152.18
MOL File
50-44-2.mol
More
Less

6-Mercaptopurine Property

Melting point:
241-244°C
Boiling point:
498.6±37.0 °C(Predicted)
Density 
1.463 (estimate)
refractive index 
1.5605 (estimate)
storage temp. 
Inert atmosphere,2-8°C
solubility 
DMSO : 35.71 mg/mL (234.66 mM; Need ultrasonic)
pka
7.77, 11.17(at 25℃)
form 
solid
Water Solubility 
124mg/L(25 ºC)
CAS DataBase Reference
50-44-2(CAS DataBase Reference)
IARC
3 (Vol. 26, Sup 7) 1987
EPA Substance Registry System
Mercaptopurine (50-44-2)
More
Less

Safety

RIDADR 
3249
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
2933599590
Hazardous Substances Data
50-44-2(Hazardous Substances Data)
Toxicity
LD50 oral in rat: 277mg/kg
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Tocris
Product number
4103
Product name
6-Mercaptopurine
Purity
≥99%(HPLC)
Packaging
50
Price
$52
Updated
2021/12/16
Usbiological
Product number
254441
Product name
6-Mercaptopurine
Packaging
50mg
Price
$283
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
MTB0002185
Product name
1,9-DIHYDROPURINE-6-THIONE
Purity
95.00%
Packaging
5MG
Price
$501.73
Updated
2021/12/16
AK Scientific
Product number
H348
Product name
6-Mercaptopurine
Packaging
100g
Price
$774
Updated
2021/12/16
ApexBio Technology
Product number
A2355
Product name
Mercaptopurine(6-MP)
Packaging
10mM(in 1mL DMSO)
Price
$55
Updated
2021/12/16
More
Less

6-Mercaptopurine Chemical Properties,Usage,Production

Chemical Properties

Yellowish-Greenish Solid

Originator

Purinethol,Sandoz,France,1950

Uses

Has a cytotoxicity effect

Uses

6-Mercaptopurine (6-MP) is a antineoplastic, immonusupressant; inhibits purine nucleotide synthesis and metabolism. 6-MP have been used for several decades in the treatment of leukemia and certain other neoplastic diseases. 6-Mercaptopurine is used for maintenance therapy of acute lymphocytic and acute myelogenous leukemia.

Definition

A sulfurcontaining purine base not found in animal nucleoproteins.

Manufacturing Process

7.5 g of 4-amino-6-chloro-5-nitropyrimidine was suspended in 200 ml of 1 N potassium hydrosulfide and heated on the steam bath for 2 hours while passing hydrogen sulfide through the reaction mixture. The reaction mixture was allowed to cool slowly, acidified with 10 N sulfuric acid and chilled. The precipitate consisted of 4,5-diamino-6-mercaptopyrimidine and sulfur. It was boiled with 300 ml of water, filtered hot and then chilled. The product precipitated as pale yellow needles (4.2 g); an additional 0.95 g was obtained by concentration of the mother liquors to 100 ml.
A mixture of 2 g of 4,5-diamino-6-mercaptopyrimidine and 10 ml of 98% formic acid was heated at 70°C for two hours and then evaporated to dryness on the steam bath to give as a residue, 7-amino-thiazolo (5,4-d) pyrimidine.
To 820 mg of 7-amino-thiazolo[5,4-d]pyrimidine was added 2.5 cc of 2 N sodium hydroxide. The water was removed under reduced pressure. The sodium salt was then heated at 240°C for one hour, during which time it melted, gave off water and resolidified. The sodium salt of 6-mercaptopurine was dissolved in 15 ml of water and acidified to pH 5 with acetic acid. Yellow crystals of 6-mercaptopurine hydrate precipitated, according to US Patent 2,933,498.

brand name

Purinethol (Teva).

Therapeutic Function

Cancer chemotherapy

Hazard

Questionable carcinogen.

Safety Profile

Poison by ingestion, intraperitoneal, subcutaneous, parenteral, and intravenous routes. Human systemic effects by ingestion: dermatitis. Experimental teratogenic and reproductive effects. Questionable human carcinogen producing Hodgkin's disease and leukemia. Human mutation data reported. When heated to decomposition it emits very toxic fumes of SOx and NOx. See also MERCAPTANS.

Veterinary Drugs and Treatments

Veterinary uses of mercaptopurine include adjunctive therapy of lymphosarcoma, acute leukemias, and severe rheumatoid arthritis. It may have potential benefit in treating other autoimmune conditions (e.g., unresponsive ulcerative colitis) as well.

6-Mercaptopurine Preparation Products And Raw materials

Raw materials

Xanthine 4,5-Diamino-6-hydroxypyrimidine Sodium dithionite Ethanol Tetrabromobisphenol A 6-Hydroxypurine Phosphorus pentasulfide Sodium ethoxide 6-Aminothiouracil Government regulation Ethyl cyanoacetate

Preparation Products

Azathioprine
More
Less

6-Mercaptopurine Suppliers

Canada 2 China 245 Europe 3 Finland 2 Germany 4 India 12 Russia 1 Slovakia 1 Switzerland 1 Ukraine 1 United Kingdom 13 United States 41 Global 326
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18217
Advantage
66
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
zhangsn@titansci.com
Country
China
ProdList
14113
Advantage
59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696;
Email
info@hanhongsci.com
Country
China
ProdList
42982
Advantage
64
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8849
Advantage
52
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12990
Advantage
57
Nanjing Vital Chemical Co., Ltd.
Tel
Please Send Email 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
4388
Advantage
65
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9872
Advantage
52
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12338
Advantage
58
Shanghai Topbiochem Technology Co., Ltd
Tel
+86-21-60341587
Fax
+86-21-61294319
Email
sales@topbiochem.com
Country
China
ProdList
6181
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19918
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7553
Advantage
61
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18216
Advantage
56
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
18521735133 18521732826;
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25015
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9552
Advantage
55
Suizhou HongQi Chemical Corporation Limited
Tel
0722-3257376 13026100080
Fax
0722-3257381
Email
774811011@qq.com
Country
China
ProdList
64
Advantage
55
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9906
Advantage
55
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3750
Advantage
55
TargetMol Chemicals Inc.
Tel
021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7934
Advantage
58
Quzhou Juhua Friendship Co., Ltd
Tel
0570-3066667
Fax
0570-3063388
Country
China
ProdList
3933
Advantage
58
Cato Research Chemicals Inc.
Tel
020-81960175
Fax
+1-541-2553641
Email
min.he@cato-chem.com
Country
China
ProdList
1958
Advantage
55
Wuhan DKY Technology Co.,Ltd.
Tel
27-81302488 18007166089
Fax
027-81302088
Email
info@dkybpc.com
Country
China
ProdList
2024
Advantage
58
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9986
Advantage
55
Bide Pharmatech Ltd.
Tel
400-1647117 15221909166
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41438
Advantage
60
Chemwill Asia Co.,Ltd.
Tel
86-21-51086038
Fax
86-21-51861608
Country
China
ProdList
2931
Advantage
58
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7892
Advantage
56
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15185
Advantage
58
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9636
Advantage
58
Beijing FYF Chemicals Co., Ltd
Tel
010-61647239; 15318973357
Fax
010-57903446
Email
1460285141@qq.com
Country
China
ProdList
2948
Advantage
58
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10287
Advantage
55
Tianjin Anhao Biological Technology Co., Ltd.
Tel
Email
sales@ahpharmatech.com
Country
China
ProdList
5738
Advantage
55
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
15878
Advantage
55
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2989
Advantage
60
Credit Asia Chemical Co., Ltd.
Tel
+86 (21) 61124340
Fax
+86 (21) 6129-4103
Country
China
ProdList
9767
Advantage
58
Hubei Jusheng Technology Co.,Ltd
Tel
027-59599241 18871490274
Fax
027-59599241
Email
1400878000@qq.com
Country
China
ProdList
9972
Advantage
58
Struchem Co., Ltd.
Tel
0512-0512-63009836 15365350169
Fax
0512-63006936
Email
helen@struchem.com
Country
China
ProdList
3989
Advantage
60
Hubei Kangbaotai Finechem Co., Ltd.
Tel
+86 (27) 8778653
Fax
+86 (27) 8773-8652
Email
13720228325@163.com
Country
China
ProdList
337
Advantage
58
Chengdu Research Accelerators Technology Co., Ltd.
Tel
028-64353063
Fax
028-64353063 QQ:784253935
Email
reacchemical@163.com
Country
China
ProdList
5259
Advantage
58
Chengdu RunZeBenTu Chemical Co., Ltd
Tel
028-88469284 18000562381
Email
rzbtsj@163.com
Country
China
ProdList
9958
Advantage
56
Nanjing Vital Chemical Co., Ltd.
Tel
025-87193546 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
9030
Advantage
60
ShangHai Siyan Biological Technology Co., Ltd.
Tel
021-50908862，442785678，326799392 18721037013
Fax
021-50908862
Email
siyansales@126.com
Country
China
ProdList
9638
Advantage
58
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9709
Advantage
58
Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
Country
China
ProdList
3868
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
27322
Advantage
60
Shanghai QianYan Bio-technology Co., Ltd
Tel
02781293128
Email
orders@biochemsafebuy.com
Country
China
ProdList
9934
Advantage
55
Shandong Xiya Chemical Co., Ltd.
Tel
4009903999 13395398332
Fax
0539-6365991
Email
sales@xiyashiji.com
Country
China
ProdList
20810
Advantage
60
Chengdu Dianchun Technology Co., Ltd
Tel
400-1166-196 18502815961
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
14623
Advantage
60
Grader reagent
Tel
18221735425
Email
sales@xinpingchem.com
Country
China
ProdList
9951
Advantage
58
Shanghai SuperLan Chemcial Technique Centre
Tel
021-2022843681 15618226720
Fax
+86-21-51601218
Email
chaolaichem@foxmail.com
Country
China
ProdList
7565
Advantage
58
More
Less

View Lastest Price from 6-Mercaptopurine manufacturers

Henan Fengda Chemical Co., Ltd
Product
6-Mercaptopurine 50-44-2
Price
US $122.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-01-11
Hebei Mojin Biotechnology Co., Ltd
Product
6-Mercaptopurine 50-44-2
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-08-30
Hebei Lingding Biotechnology Co., Ltd.
Product
6-Mercaptopurine 50-44-2
Price
US $100.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
9000kg/per week
Release date
2021-09-18

50-44-2, 6-Mercaptopurine Related Search:

POTASSIUM THIOGLYCOLATE 6-Mercaptohexan-1-ol Sodium thioglycolate 3-Mercaptopropionic acid ISOOCTYL 3-MERCAPTOPROPIONATE Mercaptoacetic acid Calcium thioglycolate Purine 2-Ethylhexyl mercaptoacetate 6-THIOGUANOSINE 6-(Methylthio)purine 2-Mercaptoethanol 6-Thioguanine Malathion 6-MERCAPTOPURINE RIBOSIDE 2,6-Dithiopurine 2-AMINO-6-HYDROXY-8-MERCAPTOPURINE 97% 6-MERCAPTOPURINE extrapure,MERCAPTOPURINE,MONOHYDRATE,USP,6-Mercaptopurine monohydrate, 99.5+%

  • THIOPURINE
  • mercaptopurine，6-MP
  • mercaptopurin
  • mercapurin
  • merkaptopuryna
  • mern
  • nci-c04886
  • nsc755
  • purimethol
  • MERCAPTOPURINE MONOHYDRATE, 6-(RG)
  • 1,9-Dihydropurine-6-thioneDISCONTINUED, see M225450
  • 6-THIOPURINE 99%
  • mercaptop
  • Ismipurine
  • Azathioprine EP Impurity B
  • 6-Mercaptopurine-13C1-15N2
  • 6-MP;MERCAPTOPURINE
  • 1H-Purine-6(9H)-thione
  • 3,7-Dihydro-6H-purine-6-thione, 6-Thiopurine, 6-Thiohypoxanthine, Purine-6-thiol
  • 3H-purine-6(7H)-thione
  • LEUKERIN
  • 1,7-Dihydro-6H-purine-6-thione
  • 7H-PURINE-6-THIOL
  • 7-mercapto-1,3,4,6-tetrazaindene
  • 6-MERCAPTOPURINE
  • 6-PURINETHIOL
  • 3h-purine-6-thiol
  • PURINE-6-THIOL
  • 1,7-dihydro-6h-purine-6-thion
  • 6-mercaptopurin
  • 6-mercapto-purin
  • 6-merkaptopurin
  • 6mp
  • 6-THIOPURINE
  • 6-thioxopurine
  • 6-THIOHYPOXANTHINE
  • ismipur
  • leupurin
  • mercaleukin
  • mercapto-6purine
  • purinethiol
  • purinethol
  • thio-hypoxanthin
  • u-4748
  • PURINE-6(1H)-THIONE
  • Mercaptopurine USP
  • 6-Mercaptopurine,>99%
  • 1,9-Dihydropurine-6-thione
  • 1H-Purine-6(7H)-thione
  • 6H-Purine-6-thione, 1,9-dihydro-
  • 3,7-dihydro-6H-purine-6-thione
  • mere apt opurine
  • 6-Mercaptopurine USP/EP/BP
  • MercaptopurineQ: What is Mercaptopurine Q: What is the CAS Number of Mercaptopurine Q: What is the storage condition of Mercaptopurine
  • Isoxaben Impurity 38
  • 6-Mercaptopurine (Azathioprine EP Impurity B)
  • 9H-purine-6-thiol
  • 50-44-2