6-ACETYL-7-DEACETYLFORSKOLIN

6-ACETYL-7-DEACETYLFORSKOLIN Property

Melting point:

220-222 °C(Solv: chloroform (67-66-3); methanol (67-56-1))

Boiling point:

524.5±50.0 °C(Predicted)

Density 

1.23±0.1 g/cm3(Predicted)

storage temp. 

−20°C

solubility 

Chloroform: Soluble; DMSO: Soluble

form 

A solid

pka

11.03±0.70(Predicted)

color 

White to off-white

optical activity

[α]/D -8 to -5°, c =0.5 in chloroform-d

Safety

Hazard Codes 

Xn

Risk Statements 

21

Safety Statements 

36

WGK Germany 

3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H312Harmful in contact with skin

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P501Dispose of contents/container to..…

6-ACETYL-7-DEACETYLFORSKOLIN Chemical Properties,Usage,Production

Uses

Iso-Forskolin is a byproduct in the synthesis of 9-Deoxyforskolin (D239935) from Coleus forskohlii, which is an adenylyl cyclase isoform activator; Antihypertensive.

Uses

6-Acetyl-7-deacetylforskolin is a bioactive constituents from the medical plant, Coleus forskohlii. Also, it has anticancer and glucosidase inhibition activities.

General Description

This substance is supplied with certified chromatographic purity. The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Biological Activity

Isoforskolin is a naturally occurring diterpene with anti-inflammatory activity. It has been shown to downregulate the expression of proinflammatory compounds. In an experimental mouse model of Lyme Disease induced arthritis isoforskolin downregulated the transcription and expression of TNF-α and IL-6 induced by recombinant Borrelia burgdorferi basic membrane protein A (rBmpA). In a r at asthmatic model isoforskolin down-regulated production of transforming growth factor β1 (TGF-β1) and interleukin-1β (IL-1β) which was accompanied by inhibition of inflammation and airway remodeling.