1-N-Cbz-3-pyrrolidinone

Product Name: 1-N-Cbz-3-pyrrolidinone
CAS No.: 130312-02-6
Chemical Name: 1-N-Cbz-3-pyrrolidinone
Synonyms: 1-Z-3-PYRROLIDINONE;N-CBZ-3-PYRROLIDINONE;1-CBZ-3-PYRROLIDINONE;1-N-CBZ-3-PYRROLIDINONE;1-Z-3-Pyrrolidinone 96%;1-CBZ-3-ketopyrrolidine;1-Carbobenzoxy-3-pyrrolidone;1-N-CBZ-3-PYRROLIDINONE, 90+%;1-Carbobenzyloxy-3-pyrrolidone;1-Carbobenzoxy-3-pyrrolidinone
CBNumber: CB1432521
Molecular Formula: C12H13NO3
Formula Weight: 219.24
MOL File: 130312-02-6.mol

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1-N-Cbz-3-pyrrolidinone Property

Melting point:: 45-47°C
Boiling point:: 370.2±42.0 °C(Predicted)
Density: 1.1897 g/mL at 25 °C
refractive index: n20/D 1.5410
Flash point:: >230 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
pka: -1.84±0.20(Predicted)
color: White to Light yellow to Light orange
InChI: InChI=1S/C12H13NO3/c14-11-6-7-13(8-11)12(15)16-9-10-4-2-1-3-5-10/h1-5H,6-9H2
InChIKey: LMHWEUQNJRXMCD-UHFFFAOYSA-N
SMILES: N1(C(OCC2=CC=CC=C2)=O)CCC(=O)C1
CAS DataBase Reference: 130312-02-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22-40
Safety Statements: 23-24/25-36/37
WGK Germany: 2
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 661201
Product name: 1-Z-3-Pyrrolidinone
Purity: 96%
Packaging: 5g
Price: $71.49
Updated: 2025/07/31

Sigma-Aldrich

Product number: 661201
Product name: 1-Z-3-Pyrrolidinone
Purity: 96%
Packaging: 1g
Price: $42.4
Updated: 2023/06/20

TCI Chemical

Product number: C2437
Product name: 1-Carbobenzoxy-3-pyrrolidone
Purity: >98.0%(GC)
Packaging: 1g
Price: $32
Updated: 2025/07/31

TCI Chemical

Product number: C2437
Product name: 1-Carbobenzoxy-3-pyrrolidone
Purity: >98.0%(GC)
Packaging: 5g
Price: $158
Updated: 2025/07/31

Oakwood

Product number: 011610
Product name: 1-N-Cbz-3-pyrrolidinone
Purity: 96%
Packaging: 1g
Price: $10
Updated: 2021/12/16

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1-N-Cbz-3-pyrrolidinone Chemical Properties,Usage,Production

Chemical Properties

Light yellow solid

Synthesis

95656-88-5

130312-02-6

General procedure for the synthesis of N-Cbz-3-pyrrolidinone from N-CBZ-3-hydroxypyrrolidine: intermediate 6.iii (1.10 g) was dissolved in dichloromethane (DCM, 8 mL) and cooled to 0 °C. Under stirring, N,N-diisopropylethylamine (DIPEA, 2.5 mL) was added slowly and dropwise, followed by a solution of sulfur trioxide pyridine complex (1.79 g) in dimethyl sulfoxide (DMSO, 6.5 mL). The reaction mixture was stirred continuously at 0 °C for 1 h, after which the reaction was quenched by the addition of water (6 mL). The aqueous phase was extracted with a solvent mixture of ether/hexane (1:1, 3 × 5 mL) and the organic phases were combined. After the organic phase was concentrated under vacuum, the residue obtained was solubilized with a solvent mixture of ether/hexane (1:1) and purified by silica gel column chromatography (n-hexane/ethyl acetate, 5:5) to give 1.05 g (96% yield) of the light yellow oily product N-Cbz-3-pyrrolidinone. The product was characterized by 1H NMR (DMSO-d6; δ ppm): 2.48-2.61 (2H, m); 3.61-3.80 (4H, m); 5.09 (2H, s); 7.27-7.41 (5H, m).

References

[1] Patent: US2009/247578, 2009, A1. Location in patent: Page/Page column 14
[2] Patent: WO2008/56335, 2008, A1. Location in patent: Page/Page column 34
[3] Patent: WO2014/32, 2014, A1. Location in patent: Page/Page column 51; 52
[4] Chemical Communications, 2007, # 21, p. 2136 - 2138
[5] Patent: WO2017/216726, 2017, A1. Location in patent: Page/Page column 581

1-N-Cbz-3-pyrrolidinone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-N-Cbz-3-pyrrolidinone manufacturers

Hebei Chuanghai Biotechnology Co,.LTD

Product: 1-N-Cbz-3-pyrrolidinone 130312-02-6
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99.8%
Supply Ability: 100000kgs
Release date: 2024-08-23

Shaanxi Dideu Medichem Co. Ltd

Product: 1-N-Cbz-3-pyrrolidinone 130312-02-6
Price: US $998.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 1T
Release date: 2020-07-06

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-N-Cbz-3-pyrrolidinone 130312-02-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

130312-02-6, 1-N-Cbz-3-pyrrolidinoneRelated Search:

N-Vinyl-2-pyrrolidone 2-Pyrrolidinone Pyrrolidine 3-Pyrrolidinone Polyvinylpyrrolidone Crospovidone N-Methyl-2-pyrrolidone Ethyl N-Cbz-4-Oxopyrrolidine-3-carboxylate METHYL-2-PYRROLIDONE 4,4-PENTAMETHYLENE-2-PYRROLIDINONE 1-CBZ-3-PYRROLIDINONE,N-CBZ-3-PYRROLIDINONE 4,4-PENTAMETHYLENE-2-PYRROLIDINONE 4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]-2-PYRROLIDINONE 4-PHENYL-2-PYRROLIDINONE Pyrrole 2-Pyrrolidineacetic acid, 3-oxo-1-[(phenylmethoxy)carbonyl]-, ethyl ester N-CBZ-4-OXO-D-PROLINE N-CBZ-2-AZABICYCLO[2.2.1]HEPTAN-7-ONE

N-CBZ-3-PYRROLIDINONE

N-BENZYLOXYCARBONYL-3-PYRROLIDINONE

3-OXO-1-PYRROLIDINECARBOXYLIC ACID, PHENYLMETHYL ESTER

3-OXO-PYRROLIDINE-1-CARBOXYLIC ACID BENZYL ESTER

1-Z-3-PYRROLIDINONE

1-N-CBZ-3-PYRROLIDINONE

1-CBZ-3-PYRROLIDINONE

1-CARBOBENZYLOXY-3-PYRROLIDINONE

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1-BENZYLOXYCARBONYL-3-PIPERIDINONE

Pyrrolidin-3-one, N-CBZ protected 97%

1-N-CBZ-3-PYRROLIDINONE, 90+%

1-Cbz-3-pyrrolidinone 1-Carbobenzoxy-3-pyrrolidinone 1-Cbz-3-pyrrolidone

1-Benzyloxycarbonyl-3-pyrrolidinone

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Pyrrolidin-3-one, N-CBZ protected

1-Carbobenzyloxy-3-pyrrolidinone, 1-Cbz-3-pyrrolidinone, 3-Oxo-1-pyrrolidinecarboxylic acid, phenylmethyl ester, 3-Oxopyrrolidine-1-carboxylic acid benzyl ester, N-Benzyloxycarbonyl-3-pyrrolidinone

1-Benzyloxycarbonylpyrrolidin-3-one

1-Pyrrolidinecarboxylic acid, 3-oxo-, phenylmethyl ester

1-Z-3-Pyrrolidinone 96%

1-CBZ-3-ketopyrrolidine

1-Carbobenzyloxy-3-pyrrolidone

1-Carbobenzoxy-3-pyrrolidone &gt

1-Benzyloxycarbonyl-3-pyrrolidone

1-Carbobenzoxy-3-pyrrolidinone

130312-02-6

Building Blocks

C11 to C30+

Chemical Synthesis

Heterocyclic Building Blocks

Pyrrolidines

Pyrrole&Pyrrolidine&Pyrroline

other