CILOSTAMIDE
- Product Name
- CILOSTAMIDE
- CAS No.
- 68550-75-4
- Chemical Name
- CILOSTAMIDE
- Synonyms
- OCP 3689;OPC 3689;CILOSTAMIDE;ciloalaMide;Cilostamide,OPC 3689;Cilostamide - CAS 68550-75-4 - Calbiochem;N-cyclohexyl-4-[(2-hydroxyquinolin-6-yl)oxy]-N-methylbutanamide;6-[3-(N-Cyclohexyl-N-methylcarbamoyl)propoxy]quinolin-2[1H]-one;N-CYCLOHEXYL-N-METHYL-4-(1,2-DIHYDRO-2-OXO-6-QUINOLYLOXY)BUTYRAMIDE;N-Cyclohexyl-4-[(1,2-dihydro-2-oxoquinolin-6-yl)oxy]-N-methylbutyramide
- CBNumber
- CB1444199
- Molecular Formula
- C20H26N2O3
- Formula Weight
- 342.43
- MOL File
- 68550-75-4.mol
CILOSTAMIDE Property
- Melting point:
- 186～188℃
- Boiling point:
- 594.3±50.0 °C(Predicted)
- Density
- 1.18±0.1 g/cm3(Predicted)
- storage temp.
- 0-6°C
- solubility
- Soluble in DMSO (up to 30 mg/ml).
- form
- White solid
- pka
- 11.12±0.70(Predicted)
- color
- White
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Safety
- RIDADR
- 3249
- WGK Germany
- 3
- HazardClass
- 6.1(b)
- PackingGroup
- III
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C7971
- Product name
- Cilostamide
- Purity
- phosphodiesterase inhibitor
- Packaging
- 5mg
- Price
- $485
- Updated
- 2024/03/01
- Product number
- 231085
- Product name
- Cilostamide
- Packaging
- 10mg
- Price
- $332
- Updated
- 2024/03/01
- Product number
- J65319
- Product name
- Cilostamide
- Packaging
- 10mg
- Price
- $135.65
- Updated
- 2024/03/01
- Product number
- 14455
- Product name
- Cilostamide
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $74
- Updated
- 2024/03/01
- Product number
- 14455
- Product name
- Cilostamide
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $140
- Updated
- 2024/03/01
CILOSTAMIDE Chemical Properties,Usage,Production
Description
Cilostamide (68550-75-4) is a selective inhibitor of phosphodiesterase-3 (PDE3). Displays limited selectivity for PDE3A versus PDE3B (IC50 = 27 and 50 nM).1,2 Blocks PKB/Akt signaling pathway downstream via inhibition of Akt-activated PDE3B.3 Cilostamide reverses the effect of leptin on food intake and body weight.4
Uses
Serotonin receptor ligand
Uses
Cilostamide (OPC 3689) is a specific phosphodiesterase 3 (PDE3) inhibitor.
Definition
ChEBI: N-cyclohexyl-N-methyl-4-[(2-oxo-1H-quinolin-6-yl)oxy]butanamide is a member of quinolines.
Biological Activity
Selective inhibitor of type III phosphodiesterase (PDE3). Displays moderate selectivity for PDE3A isozyme vs. PDE3B (IC 50 values are 0.027 and 0.050 μ M for PDE3A and PDE3B respectively). Inhibits ADP-induced platelet aggregation (IC 50 = 16.8 μ M); anti-thrombotic. Also available as part of the Phosphodiesterase Inhibitor Tocriset™ .
Biochem/physiol Actions
Selective inhibitor of PDE3 (cGMP-inhibited phosphodiesterase); IC50 = 70 ± 9 nM. This inhibitory effect increases intracellular cAMP and inhibits platelet aggregation.
storage
Store at RT
References
1) Hidaka et al. (1979), Selective inhibitor of platelet cyclic adenosine monophosphate phosphodiesterase, cilostamide, inhibits platelet aggregation; J. Pharmacol. Exp. Ther., 211 26 2) Christensen and Torphy et al. (1994), Isozyme-Selective Phosphodiesterase Inhibitors as Antiasthmatic Agents; Annu. Rep. Med. Chem., 29 185 3) Ahmad et al. (2000), Cyclic nucleotide phosphodiesterase 3B is a downstream target of protein kinase B and may be involved in regulation of effects of protein kinase B on thymidine incorporation in FDCP2 cells; J. Immunol., 164 4678 4) Zhao et al. (2002), A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding; Nat. Neuroscience, 5 727
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