CILOSTAMIDE
- Product Name
- CILOSTAMIDE
- CAS No.
- 68550-75-4
- Chemical Name
- CILOSTAMIDE
- Synonyms
- OCP 3689;OPC 3689;CILOSTAMIDE;ciloalaMide;Cilostamide,OPC 3689;Cilostamide, 10 mM in DMSO;Cilostamide, PDE3 inhibitor;Cilostamide - CAS 68550-75-4 - Calbiochem;N-cyclohexyl-4-[(2-hydroxyquinolin-6-yl)oxy]-N-methylbutanamide;6-[3-(N-Cyclohexyl-N-methylcarbamoyl)propoxy]quinolin-2[1H]-one
- CBNumber
- CB1444199
- Molecular Formula
- C20H26N2O3
- Formula Weight
- 342.43
- MOL File
- 68550-75-4.mol
CILOSTAMIDE Property
- Melting point:
- 186～188℃
- Boiling point:
- 594.3±50.0 °C(Predicted)
- Density
- 1.18±0.1 g/cm3(Predicted)
- storage temp.
- 0-6°C
- solubility
- Soluble in DMSO (up to 30 mg/ml).
- form
- White solid
- pka
- 11.12±0.70(Predicted)
- color
- White
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Safety
- RIDADR
- 3249
- WGK Germany
- 3
- HazardClass
- 6.1(b)
- PackingGroup
- III
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C7971
- Product name
- Cilostamide
- Purity
- phosphodiesterase inhibitor
- Packaging
- 5mg
- Price
- $499
- Updated
- 2025/07/31
- Product number
- 231085
- Product name
- Cilostamide
- Packaging
- 10mg
- Price
- $341
- Updated
- 2025/07/31
- Product number
- 14455
- Product name
- Cilostamide
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $74
- Updated
- 2024/03/01
- Product number
- 14455
- Product name
- Cilostamide
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $140
- Updated
- 2024/03/01
- Product number
- 14455
- Product name
- Cilostamide
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $292
- Updated
- 2024/03/01
CILOSTAMIDE Chemical Properties,Usage,Production
Description
Cilostamide (68550-75-4) is a selective inhibitor of phosphodiesterase-3 (PDE3). Displays limited selectivity for PDE3A versus PDE3B (IC50 = 27 and 50 nM).1,2 Blocks PKB/Akt signaling pathway downstream via inhibition of Akt-activated PDE3B.3 Cilostamide reverses the effect of leptin on food intake and body weight.4
Uses
Serotonin receptor ligand
Uses
Cilostamide (OPC 3689) is a specific phosphodiesterase 3 (PDE3) inhibitor.
Definition
ChEBI: N-cyclohexyl-N-methyl-4-[(2-oxo-1H-quinolin-6-yl)oxy]butanamide is a member of quinolines.
Biological Activity
Selective inhibitor of type III phosphodiesterase (PDE3). Displays moderate selectivity for PDE3A isozyme vs. PDE3B (IC 50 values are 0.027 and 0.050 μ M for PDE3A and PDE3B respectively). Inhibits ADP-induced platelet aggregation (IC 50 = 16.8 μ M); anti-thrombotic. Also available as part of the Phosphodiesterase Inhibitor Tocriset™ .
Biochem/physiol Actions
Selective inhibitor of PDE3 (cGMP-inhibited phosphodiesterase); IC50 = 70 ± 9 nM. This inhibitory effect increases intracellular cAMP and inhibits platelet aggregation.
storage
Store at RT
References
[1] H HIDAKA. Selective inhibitor of platelet cyclic adenosine monophosphate phosphodiesterase, cilostamide, inhibits platelet aggregation.[J]. Journal of Pharmacology and Experimental Therapeutics, 1979, 211 1: 26-30.
[2] S. CHRISTENSEN T T. Chapter 19. Isozyme-Selective Phosphodiesterase Inhibitors as Antiasthmatic Agents[J]. Annual Reports in Medicinal Chemistry, 1994, 29 1: 185-194. DOI:10.1016/s0065-7743(08)60732-0
[3] F AHMAD. Cyclic nucleotide phosphodiesterase 3B is a downstream target of protein kinase B and may be involved in regulation of effects of protein kinase B on thymidine incorporation in FDCP2 cells.[J]. Journal of immunology, 2000, 164 9: 4678-4688. DOI:10.4049/jimmunol.164.9.4678
[4] ALLAN Z. ZHAO. A phosphatidylinositol 3-kinase–phosphodiesterase 3B–cyclic AMP pathway in hypothalamic action of leptin on feeding[J]. Nature neuroscience, 2002, 5 8: 727-728. DOI:10.1038/nn885
CILOSTAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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