4-CHLORO-6-NITROQUINAZOLINE

Product Name: 4-CHLORO-6-NITROQUINAZOLINE
CAS No.: 19815-16-8
Chemical Name: 4-CHLORO-6-NITROQUINAZOLINE
Synonyms: 4-Chloro-6-nitro-quizoline;4-choro-6-nitroquinazoline;4-CHLORO-6-NITROQUINAZOLINE;Quinazoline,4-chloro-6-nitro-
CBNumber: CB1450967
Molecular Formula: C8H4ClN3O2
Formula Weight: 209.59
MOL File: 19815-16-8.mol

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4-CHLORO-6-NITROQUINAZOLINE Property

Melting point:: 128 °C
Boiling point:: 380.0±22.0 °C(Predicted)
Density: 1.566±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Dichloromethane
form: Solid
pka: 0.14±0.50(Predicted)
color: Brown
CAS DataBase Reference: 19815-16-8

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C374785
Product name: 4-Chloro-6-nitroquinazoline
Packaging: 250mg
Price: $1095
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H54-5-07
Product name: 4-Chloro-6-nitroquinazoline
Purity: 98%
Packaging: 250mg
Price: $50
Updated: 2021/12/16

ChemScene

Product number: CS-D0329
Product name: 4-CHLORO-6-NITROQUINAZOLINE
Packaging: 1g
Price: $98
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC20158
Product name: 4-Chloro-6-nitroquinazoline
Packaging: 10mg
Price: $139.8
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H54-5-07
Product name: 4-Chloro-6-nitroquinazoline
Purity: 98%
Packaging: 1g
Price: $202
Updated: 2021/12/16

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4-CHLORO-6-NITROQUINAZOLINE Chemical Properties,Usage,Production

Chemical Properties

Brown Solid

Uses

Intermediate in the preparation of anticancer agents and enzyme inhibitors.

Synthesis

6943-17-5

19815-16-8

Step 1: Synthesis of 4-chloro-6-nitroquinazoline To a solution of toluene (200 mL) containing 6-nitroquinazolin-4-ol (9.00 g, 47.1 mmol) and triethylamine (TEA, 9.53 g, 94.2 mmol) was slowly added phosphorus oxychloride (POCl3, 5.2 mL, 56.8 mmol) at 25 °C. Subsequently, the reaction mixture was heated to 80 °C and stirred at this temperature for 3.0 hours. Upon completion of the reaction, the mixture was cooled to 25 °C and diluted with the addition of toluene (100 mL). The organic phase was separated, washed with ice water (50 mL), dried over anhydrous sodium sulfate (Na2SO4), filtered, and concentrated by decompression to afford the title compound 4-chloro-6-nitroquinazoline as a yellow solid (7.00 g, 64.2% yield). The structure of the compound was confirmed by the following spectral data: 1H NMR (400 MHz, DMSO-d6) δ: 8.78 (s, 1H), 8.54 (d, J = 6.8 Hz, 1H), 8.39 (s, 1H), 7.87 (d, J = 12.4 Hz, 1H).

References

[1] Patent: CN108373452, 2018, A. Location in patent: Paragraph 0010; 0024; 0036-0041; 0050-0053
[2] Bioorganic and Medicinal Chemistry, 2007, vol. 15, # 12, p. 3974 - 3980
[3] Chinese Journal of Chemistry, 2014, vol. 32, # 6, p. 538 - 544
[4] Patent: WO2014/177038, 2014, A1. Location in patent: Paragraph 00255-00256
[5] Tetrahedron Letters, 2012, vol. 53, # 6, p. 674 - 677

4-CHLORO-6-NITROQUINAZOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-CHLORO-6-NITROQUINAZOLINE Suppliers

Canada 2 China 129 Germany 1 India 2 United Kingdom 1 United States 15 Global 150

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View Lastest Price from 4-CHLORO-6-NITROQUINAZOLINE manufacturers

Career Henan Chemical Co

Product: 4-CHLORO-6-NITROQUINAZOLINE 19815-16-8
Price: US $6.60/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg-1000kg
Release date: 2019-12-25

19815-16-8, 4-CHLORO-6-NITROQUINAZOLINERelated Search:

(6-Chloro-pyrimidin-4-yl)-dimethyl-amine ETHYL 4-CHLORO-6-FLUORO-3-QUINOLINECARBOXYLATE 4-CHLORO-6-FLUOROQUINAZOLINE 4-CHLORO-6-(METHYLTHIO)-1H-PYRAZOLO[3,4-D]PYRIMIDINE 2,6-Dichloro-5-nitroquinoline 8-chloro-5-nitro-quinoline 4-CHLORO-6-NITROQUINAZOLINE 6-CHLORO-5-NITROQUINOLINE 4-Chloro-3-nitroquinoline 2-CHLORO-6-NITROQUINOLINE 4-CHLORO-7-FLUORO-6-NITRO-QUINAZOLINE QUINAZOLINE, 2,4-DICHLORO-6-NITRO 4-CHLORO-7-NITROQUINAZOLINE 4-CHLORO-8-NITROQUINAZOLINE 2-[4-Methyl-1-piperazinyl]-4-chloro-7-nitroquinazoline 2-[4-Methyl-1-piperazinyl]-4-chloro-6-nitroquinazoline 4-CHLORO-6-NITRO-N-(PHENYLMETHYL)-2-QUINAZOLINECARBOXAMIDE 4-chloro-2-methyl-6-nitroquinazoline

4-CHLORO-6-NITROQUINAZOLINE

Quinazoline,4-chloro-6-nitro-

4-choro-6-nitroquinazoline

4-Chloro-6-nitro-quizoline

19815-16-8

10.9815-16-8

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals