2,4-DIETHYLPYRIDINE DICARBOXYLATE
- Product Name
- 2,4-DIETHYLPYRIDINE DICARBOXYLATE
- CAS No.
- 41438-38-4
- Chemical Name
- 2,4-DIETHYLPYRIDINE DICARBOXYLATE
- Synonyms
- 2,4-DPD;Ai3-17897;Diethyl-2,4-pdc;2,4-Pdc diethyl ester;2,4-Pyridinedicarboxylic;DIETHYL 2,4-PYRIDINECARBOXYLATE;2,4-DIETHYLPYRIDINE DICARBOXYLATE;Diethyl 2,4-pyridinedicarboxylate;diethyl pyridine-2,4-dicarboxylate;diethyl 2,4-pyridinedicarboxylic acid
- CBNumber
- CB1454066
- Molecular Formula
- C11H13NO4
- Formula Weight
- 223.23
- MOL File
- 41438-38-4.mol
2,4-DIETHYLPYRIDINE DICARBOXYLATE Property
- Melting point:
- 31 °C
- Boiling point:
- 330.9±22.0 °C(Predicted)
- Density
- 1.165±0.06 g/cm3(Predicted)
- vapor pressure
- 0.022Pa at 25℃
- storage temp.
- 2-8°C
- solubility
- ≤50mg/ml in ethanol;20mg/ml in DMSO;30mg/ml in dimethyl formamide
- pka
- -0.69±0.10(Predicted)
- form
- Crystalline
- color
- White to Almost white
- LogP
- 1.92 at 20℃ and pH7.82
- Surface tension
- 56.3mN/m at 1g/L and 19.7℃
- CAS DataBase Reference
- 41438-38-4
Safety
- HS Code
- 2933.39.9200
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- D5518
- Product name
- Diethyl 2,4-Pyridinedicarboxylate
- Purity
- >97.0%(GC)
- Packaging
- 200mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- D5518
- Product name
- Diethyl 2,4-Pyridinedicarboxylate
- Purity
- >97.0%(GC)
- Packaging
- 1g
- Price
- $186
- Updated
- 2024/03/01
- Product number
- 71200
- Product name
- 2,4-DPD
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $19
- Updated
- 2024/03/01
- Product number
- 71200
- Product name
- 2,4-DPD
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $41
- Updated
- 2024/03/01
- Product number
- 71200
- Product name
- 2,4-DPD
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $78
- Updated
- 2024/03/01
2,4-DIETHYLPYRIDINE DICARBOXYLATE Chemical Properties,Usage,Production
Biological Activity
2,4-dpd is a cell permeable, competitive inhibitor of the oxygen-sensing enzyme hif-α prolyl hydroxylase (hif-ph) [1].hypoxia-inducible factor (hif) is a transcription factor with a key role in cellular responses to hypoxia in a variety of organisms. the hif system plays an important role in angiogenesis, erythropoiesis, energy utilization, glucose/energy metabolism, tumour development, and ischaemic/hypoxic disease. genetic or pharmacological inactivation of the hif hydroxylases results in a constitutive activation of the hif pathway with little or even absent regulation by oxygen remaining. the oxygen-sensing enzyme hif-α prolyl hydroxylase catalyzes hydroxylation of specific prolyl and asparaginyl residues in the regulatory hif-α subunits [2].exposure to 2,4-dpd limited prolyl 4-hydroxylase activity in c. elegans., where their esters are hydrolyzed to form competitors of a -ketoglutarate. 2,4-dpd showed dramatic effects among the progeny. when exposed to a high level of 2,4-dpd (2.7 mm), all progeny died regardless of genotype of c. elegans. the dead embryos arrested at the twofold stage [1].
References
[1] friedman l, higgin j j, moulder g, et al. prolyl 4-hydroxylase is required for viability and morphogenesis in caenorhabditis elegans[j]. proceedings of the national academy of sciences, 2000, 97(9): 4736-4741.
[2] schofield c j, ratcliffe p j. signalling hypoxia by hif hydroxylases[j]. biochemical and biophysical research communications, 2005, 338(1): 617-626.
2,4-DIETHYLPYRIDINE DICARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4-DIETHYLPYRIDINE DICARBOXYLATE manufacturers
- Product
- Diethyl pyridine-2,4-dicarboxylate 41438-38-4
- Price
- US $1.00-10.00/kg
- Min. Order
- 0.10000000149011612kg
- Purity
- 98%+
- Supply Ability
- 1 ton
- Release date
- 2024-04-18