ChemicalBook > CAS DataBase List > Esculetin

Esculetin

Product Name: Esculetin
CAS No.: 305-01-1
Chemical Name: Esculetin
Synonyms: 6,7-DIHYDROXYCOUMARIN;AESCULETIN;Synonym;6,7-Dihydroxy-2H-chromen-2-one;Esculeti;ESCULETIN;ESCULETOL;Nsc 26428;Esculatin;Asculetine
CBNumber: CB1456020
Molecular Formula: C9H6O4
Formula Weight: 178.14
MOL File: 305-01-1.mol

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Esculetin Property

Melting point:: 271-273 °C(lit.)
Boiling point:: 270.35°C (rough estimate)
Density: 1.3431 (rough estimate)
refractive index: 1.4500 (estimate)
storage temp.: 2-8°C
solubility: Solubility Almost insoluble in boiling water, ether; soluble in hot ethanol, glacial acetic acid
form: powder
pka: 1.71(at 25℃)
color: Light yellow
PH Range: Weak blue uorescence (1.5) to strong blue uorescence (2.0)
Water Solubility: slightly soluble
Merck: 14,3697
BRN: 152788
Major Application: antiinflammatory, Herbicides, cosmetics, teeth whitening agent, antifungal, neurodegenerative andfungal, antibacterial, antiviral, treating drug-induced weight gain, neurodegenerative and blood coagulation disorders, cancer, amyloidosis, skin impairments and baldness
InChIKey: ILEDWLMCKZNDJK-UHFFFAOYSA-N
LogP: 0.980 (est)
CAS DataBase Reference: 305-01-1(CAS DataBase Reference)
NIST Chemistry Reference: Coumarin, 6,7-dihydroxy-(305-01-1)
EPA Substance Registry System: Esculetin (305-01-1)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
RTECS: GN6382500
HS Code: 29322090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0001611
Product name: Esculetin
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 25 mg
Price: $156
Updated: 2025/07/31

Sigma-Aldrich

Product number: 246573
Product name: 6,7-Dihydroxycoumarin
Purity: 98%
Packaging: 1g
Price: $79.5
Updated: 2025/07/31

Sigma-Aldrich

Product number: PHL80449
Product name: Esculetin
Purity: phyproof<SUP>®</SUP> Reference Substance
Packaging: 25 mg
Price: $334
Updated: 2025/07/31

Sigma-Aldrich

Product number: 246573
Product name: 6,7-Dihydroxycoumarin
Purity: 98%
Packaging: 5g
Price: $352
Updated: 2025/07/31

TCI Chemical

Product number: E1287
Product name: Esculetin [Matrix for MALDI-TOF/MS]
Purity: >99.0%(HPLC)(T)
Packaging: 200mg
Price: $29
Updated: 2025/07/31

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Esculetin Chemical Properties,Usage,Production

Chemical Properties

YELLOWISH CRYSTALLINE POWDER

Uses

antifungal, hepatoprotective, IL-1 inhibitor

Uses

In the presence of esculetin and HA14-1 (sc-205911) expression of the death receptor 4 (DR4) has been observed to be upregulated and extracellular-regulated kinase (ERK) to be activated. Other studies suggest that esculetin upregulates death receptor 5 (DR5) protein expression, and enhances TRAIL-induced apoptosis. It also inhibits the activity of 12-LO (12-lipoxygenase), and decreases leukotriene biosynthesis during 5-LO inhibition.

Uses

In filters for absorption of ultraviolet light.

Definition

ChEBI: A hydroxycoumarin that is umbelliferone in which the hydrogen at position 6 is substituted by a hydroxy group. It is used in filters for absorption of ultraviolet light.

General Description

Esculetin is a derivative of coumarin, found in various plant species including Cichorium intybus (chicory), Bougainvillea spectabilis, Artemisia capillaris, etc and leaves of Citrus limonia (Rutaceae), Ceratostigma willmottianum, etc. It exhibits multiple pharmacological activities and is found to be a potent inhibitor of cyclooxygenase, 5-lipoxygenase, 12-lipoxygenase, catechol-O-methyl transferase, NADPH oxidase and xanthine oxidase enzymes.

Purification Methods

It forms prisms from AcOH, aqueous EtOH or aqueous MeOH, and provides leaflets on sublimation in a vacuum. [Kagan J Am Chem Soc 88 2617 1966, Marby et al. Phytochemistry 4 492 1965.] Esculin (the 6-glucoside) has m 215o(dec), [] D -41o (c 5, pyridine). [Beilstein 18 III/IV 1322, 18/3 V 202.]

Esculetin Preparation Products And Raw materials

Raw materials

1,4-Benzoquinone

Preparation Products

SCOPARONE

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View Lastest Price from Esculetin manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: Esculetin 305-01-1
Price: US $100.00-75.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-22

Hebei Chuanghai Biotechnology Co., Ltd

Product: Esculetin 305-01-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-28

Hebei Ganmiao New material Technology Co., LTD

Product: Esculetin 305-01-1
Price: US $10.00-7.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 20ton
Release date: 2024-06-07

305-01-1, EsculetinRelated Search:

4-HYDROXY MEPHENYTOIN 1-Hydroxyethylidene-1,1-diphosphonic acid DICUMAROL 4-Methylumbelliferone Coumarin Chrysin 1,3-Dihydroxyacetone 4-Hydroxycoumarin 7-Hydroxycoumarin Butylated Hydroxytoluene Triclosan 6-Hydroxycoumarin Esculin ERIOCITRIN AESCIN IB(SH) Eribulin Erlotinib hydrochloride Eribulin Mesylate

CICHORIGENIN

CICHERINGENIN

ESCULETOL

ESCULETIN

LABOTEST-BB LT00233229

AESCULETIN

AKOS 215-98

6,7-DIHYDROXY-CHROMEN-2-ONE

6,7-DIHYDROXYCOUMARIN

2H-1-BENZOPYRAN-2-ONE, 6,7-DIHYDROXY-

2H-1-Benzopyran-2-one, 6,7-dihydroxy- (9CI)

Coumarin, 6,7-dihydroxy-

Coumarin, 6,7-dihydroxy- Esculetin

Esculeti

Aesculetin(Esculetin)

Nsc 26428

6,7-Dihydroxy-2-benzopyrone

6,7-dihydroxy-2h-1-benzopyran-2-on

6,7-dihydroxy-2h-1-benzopyran-2-one

6,7-Dihydroxy-2H-chromen-2-one

6,7-dihydroxy-coumari

Asculetine

Cichoriin aglucon

Cichoriin aglycon

cichoriinaglycon

Esculatin

Esculin aglucon

Esculin aglycon

Esculetin [Matrix for MALDI-TOF/MS]

Synonym

ESCULETIN(P)

Esculetine

ESCULETIN, 98+%

6,7-DIHYROXYCOUMARIN

6,7-Dihydroxycoumarin, 98+%

Esculetin (=6,7-DihydroxycouMarin)

Cichorigenin, Esculetin

Esculetin，Esculetine，Cichorigenin

6,7-dihydroxy-1-benzopyran-2-one

Esculetin&gt

Esculetin CRS

Esculetin USP/EP/BP

TIANFU-CHEM - Esculetin

Esculetin (6CI)

Aesculetin Powder

Esculetin-RM

Dimethylacetamide Impurity 2 (Dimethylacetamide EP Impurity B)(N,N-Dimethylformamide)

305-01-1

C9H4O2OH2

C9H6O4

Matrix Materials (MALDI-TOF-MS)

Mass Spectrometry

BioChemical

Biochemicals and Reagents

Antitumor Agents

Cancer Research

Fluorescent Probes, Labels, Particles and Stains

Fluorescent Labels