Esculetin
- Product Name
- Esculetin
- CAS No.
- 305-01-1
- Chemical Name
- Esculetin
- Synonyms
- 6,7-DIHYDROXYCOUMARIN;AESCULETIN;Synonym;6,7-Dihydroxy-2H-chromen-2-one;Esculeti;ESCULETIN;ESCULETOL;Nsc 26428;Esculatin;Asculetine
- CBNumber
- CB1456020
- Molecular Formula
- C9H6O4
- Formula Weight
- 178.14
- MOL File
- 305-01-1.mol
Esculetin Property
- Melting point:
- 271-273 °C(lit.)
- Boiling point:
- 270.35°C (rough estimate)
- Density
- 1.3431 (rough estimate)
- refractive index
- 1.4500 (estimate)
- storage temp.
- 2-8°C
- solubility
- Solubility Almost insoluble in boiling water, ether; soluble in hot ethanol, glacial acetic acid
- form
- powder
- pka
- 1.71(at 25℃)
- color
- Light yellow
- PH Range
- Weak blue uorescence (1.5) to strong blue uorescence (2.0)
- Water Solubility
- slightly soluble
- Merck
- 14,3697
- BRN
- 152788
- Major Application
- antiinflammatory, Herbicides, cosmetics, teeth whitening agent, antifungal, neurodegenerative andfungal, antibacterial, antiviral, treating drug-induced weight gain, neurodegenerative and blood coagulation disorders, cancer, amyloidosis, skin impairments and baldness
- InChIKey
- ILEDWLMCKZNDJK-UHFFFAOYSA-N
- LogP
- 0.980 (est)
- CAS DataBase Reference
- 305-01-1(CAS DataBase Reference)
- NIST Chemistry Reference
- Coumarin, 6,7-dihydroxy-(305-01-1)
- EPA Substance Registry System
- Esculetin (305-01-1)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- RTECS
- GN6382500
- HS Code
- 29322090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 246573
- Product name
- 6,7-Dihydroxycoumarin
- Purity
- 98%
- Packaging
- 1g
- Price
- $76.9
- Updated
- 2024/03/01
- Product number
- 246573
- Product name
- 6,7-Dihydroxycoumarin
- Purity
- 98%
- Packaging
- 5g
- Price
- $341
- Updated
- 2024/03/01
- Product number
- E1287
- Product name
- Esculetin [Matrix for MALDI-TOF/MS]
- Purity
- >99.0%(HPLC)(T)
- Packaging
- 200mg
- Price
- $29
- Updated
- 2024/03/01
- Product number
- E0386
- Product name
- Esculetin
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $47
- Updated
- 2024/03/01
- Product number
- A15393
- Product name
- 6,7-Dihydroxycoumarin, 98+%
- Packaging
- 1g
- Price
- $64.65
- Updated
- 2024/03/01
Esculetin Chemical Properties,Usage,Production
Chemical Properties
YELLOWISH CRYSTALLINE POWDER
Uses
antifungal, hepatoprotective, IL-1 inhibitor
Uses
In the presence of esculetin and HA14-1 (sc-205911) expression of the death receptor 4 (DR4) has been observed to be upregulated and extracellular-regulated kinase (ERK) to be activated. Other studies suggest that esculetin upregulates death receptor 5 (DR5) protein expression, and enhances TRAIL-induced apoptosis. It also inhibits the activity of 12-LO (12-lipoxygenase), and decreases leukotriene biosynthesis during 5-LO inhibition.
Uses
In filters for absorption of ultraviolet light.
Definition
ChEBI: A hydroxycoumarin that is umbelliferone in which the hydrogen at position 6 is substituted by a hydroxy group. It is used in filters for absorption of ultraviolet light.
General Description
Esculetin is a derivative of coumarin, found in various plant species including Cichorium intybus (chicory), Bougainvillea spectabilis, Artemisia capillaris, etc and leaves of Citrus limonia (Rutaceae), Ceratostigma willmottianum, etc. It exhibits multiple pharmacological activities and is found to be a potent inhibitor of cyclooxygenase, 5-lipoxygenase, 12-lipoxygenase, catechol-O-methyl transferase, NADPH oxidase and xanthine oxidase enzymes.
Purification Methods
It forms prisms from AcOH, aqueous EtOH or aqueous MeOH, and provides leaflets on sublimation in a vacuum. [Kagan J Am Chem Soc 88 2617 1966, Marby et al. Phytochemistry 4 492 1965.] Esculin (the 6-glucoside) has m 215o(dec), [] D -41o (c 5, pyridine). [Beilstein 18 III/IV 1322, 18/3 V 202.]
Esculetin Preparation Products And Raw materials
Raw materials
Preparation Products
Esculetin Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28387
- Advantage
- 80
- Tel
- --
- Fax
- --
- reag-info@gms.kanto.co.jp
- Country
- Japan
- ProdList
- 6756
- Advantage
- 74
- Tel
- --
- Fax
- --
- labchem-tec@wako-chem.co.jp
- Country
- Japan
- ProdList
- 6819
- Advantage
- 80
View Lastest Price from Esculetin manufacturers
- Product
- Esculetin 305-01-1
- Price
- US $100.00-75.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2024-08-22
- Product
- Esculetin 305-01-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-28
- Product
- Esculetin 305-01-1
- Price
- US $10.00-7.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 20ton
- Release date
- 2024-06-07