Isonicotinic acid
- Product Name
- Isonicotinic acid
- CAS No.
- 55-22-1
- Chemical Name
- Isonicotinic acid
- Synonyms
- INA;4-PYRIDINECARBOXYLIC ACID;4-PICOLINIC ACID;PYRIDINE-3-CARBOXYLIC ACID;PYRIDINE-4-CARBOXYLIC ACID;Isonicotic acid;Isonicotinic;4-Carboxypyridine;NEF5;bidinjiausn
- CBNumber
- CB1462924
- Molecular Formula
- C6H5NO2
- Formula Weight
- 123.11
- MOL File
- 55-22-1.mol
Isonicotinic acid Property
- Melting point:
- ≥300 °C (lit.)
- Boiling point:
- 260 °C (15 mmHg)
- Density
- 1,47g/cm
- refractive index
- 1.5423 (estimate)
- Flash point:
- 260°C/15mm
- storage temp.
- no restrictions.
- solubility
- 6g/l
- pka
- 4.96(at 25℃)
- form
- powder
- color
- yellow to tan
- PH
- 3-4 (6g/l, H2O, 20℃)(saturated solution)
- Water Solubility
- 5.2 g/L (20 ºC)
- Merck
- 14,5187
- BRN
- 109599
- InChIKey
- TWBYWOBDOCUKOW-UHFFFAOYSA-N
- CAS DataBase Reference
- 55-22-1(CAS DataBase Reference)
- NIST Chemistry Reference
- Isonicotinic acid(55-22-1)
- EPA Substance Registry System
- Isonicotinic acid (55-22-1)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- I17508
- Product name
- Isonicotinic acid
- Purity
- 99%
- Packaging
- 5g
- Price
- $27.6
- Updated
- 2024/03/01
- Product number
- I17508
- Product name
- Isonicotinic acid
- Purity
- 99%
- Packaging
- 100g
- Price
- $31.6
- Updated
- 2024/03/01
- Product number
- 8.00736
- Product name
- 4-Pyridinecarboxylic acid
- Purity
- for synthesis
- Packaging
- 5G
- Price
- $34.2
- Updated
- 2024/03/01
- Product number
- 8.00736
- Product name
- 4-Pyridinecarboxylic acid
- Purity
- for synthesis
- Packaging
- 250g
- Price
- $86.3
- Updated
- 2024/03/01
- Product number
- I0207
- Product name
- Isonicotinic Acid
- Purity
- >99.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $23
- Updated
- 2024/03/01
Isonicotinic acid Chemical Properties,Usage,Production
Chemical Properties
isonicotinic acid is also known as pyridine-4-carboxylic acid. white to light yellow crystal powder or white needle crystals. odorless, sublimable. molecular weight 123.11. melting point 319°C . slightly soluble in cold water, soluble in hot water, insoluble in alcohol, benzene and ether. isonicotinic acid is an amphoteric compound that is soluble in both acids and bases. soluble in hot water and ethanol, slightly soluble in cold water and ether. stable to heat and oxidation.
Uses
Isonicotinic acid is a metabolite of isoniazid. It is an isomer of nicotinic acid. The chronic toxicity of isonicotinic acid is slightly higher than that of isonicotinic acid hydrazide ( INH ) .
Isonicotinic acid is a moderately basic compound (based on its pKa). Isonicotinic acid is an organic compound with a carboxyl group on a pyridine ring. The carboxyl group for isonicotinic acid is on the 4-position instead of the 3-position for nicotinic acid. It is an isomer of nicotinic acid. Isonicotinic acid is a metabolite of isoniazid.
Isonicotinic acid considered to be inactive isomer of nicotinic acid. Isonicotinic acid is a metabolite of pyridine-4-carboxy hydrazide (isonicotinyl hydrazide; isoniazid) a front-line weapon in the battle against tuberculosis. Isonicotinic acid and its derivatives are used in manufacturing pharmaceuticals and agrochemicals.
Used in the biological study of differentiation induced by nicotinic acid, nicotinamide and isonicotinic acid in human leukemia cell lines
Definition
ChEBI: Isonicotinic acid is a pyridinemonocarboxylic acid in which the carboxy group is at position 4 of the pyridine ring. It has a role as a human metabolite and an algal metabolite. It is a conjugate acid of an isonicotinate.
Preparation
Isonicotinic acid is synthesized by continuous oxidation with 4-methylpyridine as raw material and vanadium pentoxide as catalyst. The purity of the industrial product isonicotinic acid is more than 95%, and the yield of the above method is 70-75%. The consumption of 4-methylpyridine per ton of product is 1070kg.
Application
Isonicotinic acid (IN) can be used as:
An organocatalyst in the one pot four component condensation reaction, to synthesize pyranopyrazoles based heterocyclic compounds.
An organic ligand for the preparation of copper(I) halide coordination polymer [CuBr(IN)]n, by hydrothermal method.
As a starting material for the synthesis of cation-dimers with potent antimalarial activity.
Purification Methods
Crystallise the acid repeatedly from water and dry it under vacuum at 110o or sublime it at 260o/15mm (m 319o). [Beilstein 22 III/IV 518, 22/2 V 188.]
Isonicotinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Isonicotinic acid manufacturers
- Product
- Isonicotinic acid 55-22-1
- Price
- US $99.00-80.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2024-08-21
- Product
- Isonicotinic acid 55-22-1
- Price
- US $6.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000KG/Month
- Release date
- 2024-08-02
- Product
- Isonicotinic acid 55-22-1
- Price
- US $6.00/kg
- Min. Order
- 1kg
- Purity
- More than 99%
- Supply Ability
- 2000KG/Month
- Release date
- 2024-05-22