ML418

Product Name: ML418
CAS No.: 1928763-08-9
Chemical Name: ML418
Synonyms: ML418;inhibit,ML-418,ML418,KcsA,ML 418,Inhibitor,Potassium Channel;Isopropyl (1-((5-chloro-8-hydroxyquinolin-7-yl)methyl)piperidin-4-yl)carbamate;Carbamic acid, N-[1-[(5-chloro-8-hydroxy-7-quinolinyl)methyl]-4-piperidinyl]-, 1-methylethyl ester
CBNumber: CB14668207
Molecular Formula: C19H24ClN3O3
Formula Weight: 377.87
MOL File: 1928763-08-9.mol

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ML418 Property

Boiling point:: 545.5±50.0 °C(Predicted)
Density: 1.31±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in DMSO
pka: 12.43±0.20(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 6889
Product name: ML418
Purity: ≥98%(HPLC)
Packaging: 10
Price: $149
Updated: 2021/12/16

ChemScene

Product number: CS-0088425
Product name: ML418
Purity: 99.19%
Packaging: 5mg
Price: $140
Updated: 2021/12/16

ChemScene

Product number: CS-0088425
Product name: ML418
Purity: 99.19%
Packaging: 100mg
Price: $950
Updated: 2021/12/16

ChemScene

Product number: CS-0088425
Product name: ML418
Purity: 99.19%
Packaging: 250mg
Price: $1500
Updated: 2021/12/16

Ambeed

Product number: A1251852
Product name: Isopropyl(1-((5-chloro-8-hydroxyquinolin-7-yl)methyl)piperidin-4-yl)carbamate
Purity: 98%
Packaging: 1mg
Price: $81
Updated: 2021/12/16

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ML418 Chemical Properties,Usage,Production

Uses

ML418 is a potent, selective and CNS penetrating Kir7.1 potassium channel blocker. ML418 inhibits Kir7.1 with an IC50 value of 0.31 μM. ML418 can be used for the research of neurological, cardiovascular, endocrine and muscle disorders.

in vivo

ML418 (i.p.; 30 mg/kg) has good PK effect, excellent CNS penetration and favorable CNS distribution^[1].

Animal Model:	Rats and Mice^[1]
Dosage:	30 mg/kg
Administration:	Intraperitoneal
Result:	Showed a suitable PK profile (Cmax = 0.20 μM and Tmax = 3 h), excellent CNS penetration with a mouse brain: Kp of 10.9, brain (323.9 ng/g): plasma (29.5 ng/mL).

storage

Store at -20°C

References

[1] ML418, et al. ML418: The First Selective, Sub-Micromolar Pore Blocker of Kir7.1 Potassium Channels. ACS Chem Neurosci. 2016 Jul 20;7(7):1013-23. DOI:10.1021/acschemneuro.6b00111

ML418 Preparation Products And Raw materials

Raw materials

Preparation Products

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ML418 Suppliers

China 34 United States 3 Global 37

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

MedChemExpress

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Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

1928763-08-9, ML418Related Search:

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ML418

Carbamic acid, N-[1-[(5-chloro-8-hydroxy-7-quinolinyl)methyl]-4-piperidinyl]-, 1-methylethyl ester

Isopropyl (1-((5-chloro-8-hydroxyquinolin-7-yl)methyl)piperidin-4-yl)carbamate

inhibit,ML-418,ML418,KcsA,ML 418,Inhibitor,Potassium Channel

1928763-08-9