Fmoc-Tyr(Me)-OH

Uses

Product Name: Fmoc-Tyr(Me)-OH
CAS No.: 77128-72-4
Chemical Name: Fmoc-Tyr(Me)-OH
Synonyms: Fmoc;FMOC-L-TYR(ME);FMOC-TYR(ME)-OH;FMOC-TYR(AL)-OH;FMOC-L-TYR(ME)-OH;Fmoc-4-Methoxy-Phe;FMOC-PHE(4-OME)-OH;FMOC-L-4-METHOXYPHE;Fmoc-L-4-MeO-Phe-OH;Methoxy phenylalanine
CBNumber: CB1468274
Molecular Formula: C25H23NO5
Formula Weight: 417.45
MOL File: 77128-72-4.mol

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Fmoc-Tyr(Me)-OH Property

Melting point:: 161 °C
Boiling point:: 647.8±55.0 °C(Predicted)
Density: 1.274±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
pka: 2.97±0.10(Predicted)
form: powder to crystal
color: White to Almost white
optical activity: -26.3° (C=0.01 g/ml, DMF)
InChIKey: JYQODLWFOPCSCS-QHCPKHFHSA-N
SMILES: C(O)(=O)[C@H](CC1=CC=C(OC)C=C1)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O
CAS DataBase Reference: 77128-72-4(CAS DataBase Reference)

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Safety

WGK Germany: WGK 2 water endangering
HazardClass: IRRITANT
HS Code: 29242990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.52056
Product name: Fmoc-Tyr(Me)-OH
Purity: Novabiochem?
Packaging: 5G
Price: $124
Updated: 2025/07/31

Sigma-Aldrich

Product number: CDS006940
Product name: Fmoc-Tyr(Me)-OH
Purity: AldrichCPR
Packaging: 10MG
Price: $68.1
Updated: 2023/06/20

Sigma-Aldrich

Product number: 8.52056
Product name: Fmoc-Tyr(Me)-OH
Purity: Novabiochem?
Packaging: 1g
Price: $35.3
Updated: 2023/01/07

TCI Chemical

Product number: F1038
Product name: N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-methyl-L-tyrosine
Packaging: 1G
Price: $82
Updated: 2025/07/31

TCI Chemical

Product number: F1038
Product name: N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-methyl-L-tyrosine
Packaging: 5G
Price: $327
Updated: 2025/07/31

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Fmoc-Tyr(Me)-OH Chemical Properties,Usage,Production

Uses

Fmoc-p-methoxy-L-phenylalanine is a phenylalanine derivative protected by the Fmoc (9-fluorenylmethoxycarbonyl) group. The Fmoc protecting group is easily removed under mild conditions without destroying the amino acid's activity, making this compound an indispensable raw material in peptide synthesis. It can also be used as a key intermediate in the synthesis of ACE inhibitors for treating hypertension.

Description

Fmoc-Tyr(Me)-OH, also known as Fmoc-O-methyl-L-tyrosine, is an Fmoc protected tyrosine derivative that is potentially useful for proteomics studies and solid phase peptide synthesis techniques. Tyrosine is a important amino acid - one of the few amino acids which is phosphorylated to vary the physical properties of the peptides, and is a precursor for the formation of iodinated thyroid hormones. The Fmoc group is typically removed with a base such as pyridine - an orthogonal de-protection strategy to the acid labilie Boc group.

Chemical Properties

White to off-white powder

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

Fmoc-Tyr(Me)-OH, also known as Fmoc-Tyr(OMe)-OH, was obtained from Fmoc-Tyr(OMe)-OMe within 1h and was isolated following protocol 1 or 2 in 96% yield[1]. Under argon atmosphere, anhydrous THF (2.0 mL) was added to the protected amino acid Fmoc-Tyr(OMe)-OMe (0.12 mmol) and to MgI2 * (1.2 mmol). The suspension was heated in a sealed reactor using microwave irradiation at 120°C. A Na2S2O3 aqueous solution (0.1 M) was then added and the resulting homogeneous mixture was directly analysed by analytical HPLC and LC/MS. To isolate the product, two protocols could be applied:
Protocol 1: The crude material was purified by preparative HPLC.
Protocol 2: The crude material was extracted with AcOEt (x3). The organic layer was washed with brine, dried over MgSO4, filtered and concentrated under reduced pressure. The residue was diluted in H2O/EtOH and lyophilized.

References

[1] Berthet M, et al. MgI2 -Mediated Chemoselective Cleavage of Protecting Groups: An Alternative to Conventional Deprotection Methodologies. Chemistry - A European Journal, 2015; 21: 11014-11016.

Fmoc-Tyr(Me)-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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Fmoc-Tyr(Me)-OH Suppliers

China 162 Europe 1 Germany 5 India 5 Japan 3 Switzerland 3 United Kingdom 2 United States 32 Global 213

Sichuan HongRi Pharma-Tech Co., Ltd

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Meryer (Shanghai) Chemical Technology Co., Ltd.

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Shanghai HC Biotech Co., Ltd

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Alfa Aesar

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TCI (Shanghai) Development Co., Ltd.

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Energy Chemical

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GL Biochem (Shanghai) Ltd

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Shanghai Hanhong Scientific Co.,Ltd.

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ChemPep, Inc.

Tel: +1 (888) 615-9178 / (561) 791-8787
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View Lastest Price from Fmoc-Tyr(Me)-OH manufacturers

Shenzhen Nexcon Pharmatechs Ltd.

Product: Fmoc-Tyr(Me)-OH 77128-72-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 2000
Release date: 2025-04-21

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Fmoc-L-Tyr(me) 77128-72-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T
Release date: 2024-04-10

Career Henan Chemical Co

Product: FMOC-TYR(ME)-OH 77128-72-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20kg
Release date: 2018-08-15

77128-72-4, Fmoc-Tyr(Me)-OHRelated Search:

FMOC-TYR(BZL)-OH 98%,FMOC-TYR(BZL)-OH N-Fmoc-O-Phenyl-L-Tyrosine Fmoc-Tyr(Ac)-OH FMOC-L-4-Fluorophe Fmoc-L-4-Iodophenylalanine (S)-N-FMOC-4-Chlorophenylalanine FMOC-L-9-ANTHRYLALANINE FMOC-D, L-PHE(4-C(O)NH2) FMOC-L-4-Methylphe Fmoc-4-nitro-L-phenylalanine (S)-N-Fmoc-Allylglycine FMOC-L-4-CYANOPHENYLALANINE FMOC-TYR(ET)-OH FMOC-TYR(ALL)-OH,FMOC-TYR(AL)-OH FMOC-TYR(2-BR-Z)-OH FMOC-TYR(MALONYL-DI-OTBU)-OH Fmoc-Tyr(tBu)-OH Fmoc-Tyr(Me)-OH

Fmoc-4-Methoxy-L-Phe-OH

Methoxy phenylalanine

N-FMoc-4-Methoxy-L-phenylalanine, 95%

FMoc-Tyr(Me)-OH FMoc-O-Methyl-L-tyrosine

FMOC-(S)-b-(p-Methoxyphenyl)alanine

(S)-2-((((9H-Fluoren-9-yl)Methoxy)carbonyl)aMino)-3-(4-Methoxyphenyl)propanoic acid

N-Fmoc-O-methyl-L-tyrosine, >=99%

Fmoc-4-Methoxy-Phe

N-ALPHA-FMOC-O-METHYL-L-TYROSINE

N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-O-METHYL-L-TYROSINE

N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-O-METHYL-L-TYROSINE

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-methyl-L-tyrosine

Fmoc-O-methyl-L-tyrosine≥ 99% (HPLC)

Fmoc-Tyr(Me)-OH Novabiochem

N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-O-METHY-L-TYROSINE

N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-4-METHOXY-L-PHENYLALANINE

(S)-2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-3-(4-METHOXY-PHENYL)-PROPIONIC ACID

FMOC-4-METHOXY-PHE-OH

FMOC-4-METHOXY-L-PHENYLALANINE

FMOC-4-METHOXYPHENYLALANINE

FMOC-L-4-METHOXYPHE

FMOC-TYR(ME)-OH

FMOC-L-TYR(ME)

FMOC-L-TYR(ME)-OH

FMOC-L-TYROSINE(METHYL ETHER)

FMOC-P-METHOXY-PHE-OH

FMOC-PHE(4-OME)-OH

FMOC-O-METHYL-L-TYROSINE

FMOC-4-METHOXYPHENYLALANINE MIN 99%

Fmoc-L-4-MeO-Phe-OH

FMOC-TYR(AL)-OH

(9H-Fluoren-9-yl)MethOxy]Carbonyl Tyr(Me)-OH

(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(4-methoxyphenyl)propanoic acid

Fmoc-Tyr(Me)-OH(Fmoc-4-Methoxy-Phe)

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-methyl-L-tyrosine&gt

Fmoc-Tyr(Me)-OH (N-Fmoc-O-methyl-L-tyrosine)

L-Tyrosine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-methyl-

N-Fmoc-4-methoxy-L-phenylalanine,95%

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-methoxy-L-phenylalanine

N-Fmoc-O-methyl-L-tyrosine

FMOC-TYR(ME)-OH USP/EP/BP

Fmoc

N-Fmoc-4-methoxy-L-phenylalanine

77128-72-4

Phenylalanine [Phe, F]

Unusual Amino Acids

Amino Acids

Fmoc-Amino acid series