Fmoc-4-nitro-L-phenylalanine

Product Name: Fmoc-4-nitro-L-phenylalanine
CAS No.: 95753-55-2
Chemical Name: Fmoc-4-nitro-L-phenylalanine
Synonyms: FMOC-PHE(NO2)-OH;FMOC-PHE(4''-NO2);FMOC-L-PHE(4-NO2);FMOC-L-4-NITROPHE;Fmoc-Phe(4-NO)-OH;FMOC-PHE(4-NO2)-OH;FMOC-PHE(P-NO2)-OH;FMOC-PNO2-L-PHE-OH;FMOC-(P-NO2)PHE-OH;Fmoc-Phe(p-N02)-0H
CBNumber: CB7782510
Molecular Formula: C24H20N2O6
Formula Weight: 432.43
MOL File: 95753-55-2.mol

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Fmoc-4-nitro-L-phenylalanine Property

Melting point:: 213-223℃
Boiling point:: 692.3±55.0 °C(Predicted)
Density: 1.371±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: almost transparency in N,N-DMF
form: powder to crystal
pka: 3.59±0.10(Predicted)
color: White to Light yellow
BRN: 5178656
CAS DataBase Reference: 95753-55-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Safety Statements: 22-24/25
WGK Germany: 3
HS Code: 2924 29 70
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.52029
Product name: Fmoc-Phe(4-NO₂)-OH
Purity: Novabiochem?
Packaging: 1g
Price: $47.4
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.52029
Product name: Fmoc-Phe(4-NO₂)-OH
Purity: Novabiochem?
Packaging: 5G
Price: $182
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.52029
Product name: Fmoc-Phe(4-NO₂)-OH
Purity: Novabiochem?
Packaging: 25g
Price: $718
Updated: 2025/07/31

TCI Chemical

Product number: F0443
Product name: N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-nitro-L-phenylalanine
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $30
Updated: 2025/07/31

TCI Chemical

Product number: F0443
Product name: N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-nitro-L-phenylalanine
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $87
Updated: 2025/07/31

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Fmoc-4-nitro-L-phenylalanine Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

Fmoc-Phe(4-NO2)-OH is used to prepare squaric acid derivatives as VLA-4 integrin antagonists. It is also an intermediate used in the synthesis of analogs of kahalalide F.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

949-99-5

82911-69-1

95753-55-2

GENERAL STEPS: 37.7 g (0.179mol) of (S)-2-amino-3-(4-nitrophenyl)propionic acid was suspended in 200 mL of a 2% NaOH aqueous solution, and 80 mL of acetonitrile was added until completely dissolved. To this solution was added 61.8 g (0.183 mol) of 9-fluorenylmethyl-N-succinimidyl carbonate suspended in 100 mL of acetonitrile. The reaction mixture was stirred at room temperature for 3 h and subsequently acidified to pH 4-5 with 5% HCl. The precipitated white crystals were collected by filtration, washed with ethyl acetate and dried. The product was recrystallized by ethanol-dioxane (50:50) solvent mixture. The yields were 67% (3a) and 71% (3b), respectively. The melting point was 230 °C (literature value 233-234 °C [10]).IR spectrum (ν, cm-1): 3429, 3202, 1724, 1693, 1601, 1520, 1447, 1354, 1223, 1057, 856, 760, 741.1H NMR spectrum (DMSO-d6, δ, ppm): 2.90- 3.09 (m, 1H, CH2), 3.25 (dd, 1H, CH2, 2J=13.7, 3J=4.3 Hz), 4.13-4.34 (m, 4H, 2CH2, 2CH), 7.23-7.45 (m, 4Harom), 7.54 (d, 2Harom, 3J=8.6 Hz), 7.60-7.64 (m, 2Harom), 7.79 (d, 1H, NH, 3J=8.6 Hz), 7.88 (d, 2Harom, 3J=7.5 Hz), 8.14 (d, 2Harom, 3J=8.6 Hz), 12.93 (s, 1H, COOH).13C NMR spectra (DMSO-d6, δ, ppm): 36.62 (CH2) 47.03 (CH), 55.25 (CH), 66.03 (CH2), 120.56, 123.69, 125.62, 127.45, 128.07, 130.94, 141.16, 144.20, 146.73 (arom), 156.39 (CONH), 173.27 (COOH). Mass spectrum (ESI, m/z): 455.1214 [M+Na]+. Molecular formula C24H20N2O6, calculated molecular weight 432.1321.

References

[1] Tetrahedron Letters, 1999, vol. 40, # 36, p. 6557 - 6560
[2] Russian Journal of Organic Chemistry, 2016, vol. 52, # 11, p. 1681 - 1685
[3] Zh. Org. Khim., 2016, vol. 52, # 11, p. 1686 - 1690,5

Fmoc-4-nitro-L-phenylalanine Preparation Products And Raw materials

Raw materials

Preparation Products

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Fmoc-4-nitro-L-phenylalanine Suppliers

Americas 1 China 191 Europe 2 France 2 Germany 6 Hungary 1 India 14 Japan 5 Switzerland 5 United Kingdom 9 United States 42 Global 278

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View Lastest Price from Fmoc-4-nitro-L-phenylalanine manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Fmoc-Phe(4-NO2)-OH 95753-55-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T
Release date: 2023-12-13

Sichuan Jiaying Lai Technology Co.,LTD

Product: Fmoc-Phe(4-NO2)-OH 95753-55-2
Price: US $1.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 100KG
Release date: 2019-07-24

Career Henan Chemical Co

Product: Fmoc-4-nitro-L-phenylalanine 95753-55-2
Price: US $20.00/KG
Min. Order: 10KG
Purity: 99%
Supply Ability: 100kg
Release date: 2018-07-31

95753-55-2, Fmoc-4-nitro-L-phenylalanineRelated Search:

Fmoc-Phe-OH Phenprobamate 4-Nitro-3-phenyl-L-alanine D-Phenylalanine Fmoc-Aib-OH 9-Fluorenylmethyl chloroformate N-(tert-Butoxycarbonyl)-L-phenylalanine L-Phenylalanine Fmoc-OSu FMOC-L-4-Fluorophe Fmoc-L-4-Iodophenylalanine Fmoc-Tyr(Me)-OH (S)-N-FMOC-4-Chlorophenylalanine FMOC-L-9-ANTHRYLALANINE FMOC-D, L-PHE(4-C(O)NH2) FMOC-L-4-Methylphe (S)-N-Fmoc-Allylglycine FMOC-L-4-CYANOPHENYLALANINE

Fmoc-Phe(4-NO<sub>2</sub>)-OH

9-FLUORENYLMETHOXYCARBONYL-P-NITRO-L-PHENYLALANINE

4-Nitro-L-phenylalanine, N-FMOC protected

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RARECHEM BK PT 0075

N-ALPHA-FMOC-4-NITRO-L-PHENYLALANINE

N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-4-NITRO-L-PHENYLALANINE

N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-4-NITROPHENYLALANINE

N-FMOC-P-NITRO-L-PHENYLALANINE

N-FMOC-4-NITRO-L-PHENYLALANINE

N-α-Fmoc-4-Nitro-L-Phenylananine

FMOC-PHE(4''-NO2)

N-fluorenylmethoxycarbonyl-p-nitro-L-phenylalanine

FMOC-PHE(4-NO2)-OH

FMOC-PHE(NO2)-OH

FMOC-PHE(P-NO2)-OH

FMOC-PNO2-L-PHE-OH

FMOC-(P-NO2)PHE-OH

FMOC-P-NITRO-PHENYLALANINE

FMOC-P-NITRO-PHE-OH

FMOC-L-PHE(4-NO2)

FMOC-L-PHE(4-NO2)-OH

FMOC-L-4-NITROPHE

FMOC-L-4-NITROPHENYLALANINE

FMOC-4-NITRO-L-PHENYLALANINE

FMoc-L-4-NO2-Phe-OH FMoc-4-Nitro-L-Phenylalanine

N-Fmoc-4-nitro-L-phenylalanine Fmoc-Phe(4-NO2)-OH

(S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4-nitrophenyl)propanoic acid

N-Fmoc-4-Nitro-L-phenylalanine (Fmoc-Phe(4-NO2)-OH ,99% (HPLC)

FMoc-4Nethoxyphenylalanine

Fmoc-Phe(4-NO2)-OH H2O

(S)-Fmoc-2-amino-3-(4-nitrophenyl)propionic acid

Fmoc-4-nitro-L-phenylalanine99%

Fmoc-p-nitro-L-Phe-OH

Fmoc-Phe(4-NO)-OH Novabiochem

Fmoc-4-Nitro-L-Phe-Hydrate

(9H-Fluoren-9-yl)MethOxy]Carbonyl Phe(4-NO2)-OH

(2S)-2-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]-3-(4-nitrophenyl)propanoic acid

(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(4-nitrophenyl)propanoic acid

Fmoc-Phe(4-NO)-OH

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-nitro-L-phenylalanine&gt

L-Phenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-4-nitro-

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N-(9-Fluorenyl methoxy carbonyl)-4-nitrophenylalanine

Fmoc-4-nitro-l-phenylalanine, 98%+

FMOC-4-Nitro-L-Phenylalanine extrapure (FMOC-L-Phe(4NO2)-OH), 98%

N-Fmoc-4-nitro-L-phenylalanine, 98%,

Fmoc-4-nitro-L-phenylalanine 98%

Fmoc-Phe(p-N02)-0H

95753-55-2

Unnatural Amino Acid Derivatives

Peptide Synthesis

Phenylalanine Derivatives