Fmoc-Tyr(Me)-OH
- Product Name
- Fmoc-Tyr(Me)-OH
- CAS No.
- 77128-72-4
- Chemical Name
- Fmoc-Tyr(Me)-OH
- Synonyms
- Fmoc;FMOC-L-TYR(ME);FMOC-TYR(ME)-OH;FMOC-TYR(AL)-OH;FMOC-L-TYR(ME)-OH;Fmoc-4-Methoxy-Phe;FMOC-PHE(4-OME)-OH;FMOC-L-4-METHOXYPHE;Fmoc-L-4-MeO-Phe-OH;Methoxy phenylalanine
- CBNumber
- CB1468274
- Molecular Formula
- C25H23NO5
- Formula Weight
- 417.45
- MOL File
- 77128-72-4.mol
Fmoc-Tyr(Me)-OH Property
- Melting point:
- 161 °C
- Boiling point:
- 647.8±55.0 °C(Predicted)
- Density
- 1.274±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- pka
- 2.97±0.10(Predicted)
- form
- powder to crystal
- color
- White to Almost white
- InChIKey
- JYQODLWFOPCSCS-QHCPKHFHSA-N
- SMILES
- C(O)(=O)[C@H](CC1=CC=C(OC)C=C1)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O
- CAS DataBase Reference
- 77128-72-4(CAS DataBase Reference)
Safety
- WGK Germany
- WGK 2 water endangering
- HazardClass
- IRRITANT
- HS Code
- 29242990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 8.52056
- Product name
- Fmoc-Tyr(Me)-OH
- Purity
- Novabiochem?
- Packaging
- 5G
- Price
- $121
- Updated
- 2024/03/01
- Product number
- CDS006940
- Product name
- Fmoc-Tyr(Me)-OH
- Purity
- AldrichCPR
- Packaging
- 10MG
- Price
- $68.1
- Updated
- 2023/06/20
- Product number
- 8.52056
- Product name
- Fmoc-Tyr(Me)-OH
- Purity
- Novabiochem?
- Packaging
- 1g
- Price
- $35.3
- Updated
- 2023/01/07
- Product number
- H52117
- Product name
- N-Fmoc-4-methoxy-L-phenylalanine, 95%
- Packaging
- 1g
- Price
- $57.65
- Updated
- 2024/03/01
- Product number
- H52117
- Product name
- N-Fmoc-4-methoxy-L-phenylalanine, 95%
- Packaging
- 5g
- Price
- $246.65
- Updated
- 2024/03/01
Fmoc-Tyr(Me)-OH Chemical Properties,Usage,Production
Description
Fmoc-Tyr(Me)-OH, also known as Fmoc-O-methyl-L-tyrosine, is an Fmoc protected tyrosine derivative that is potentially useful for proteomics studies and solid phase peptide synthesis techniques. Tyrosine is a important amino acid - one of the few amino acids which is phosphorylated to vary the physical properties of the peptides, and is a precursor for the formation of iodinated thyroid hormones. The Fmoc group is typically removed with a base such as pyridine - an orthogonal de-protection strategy to the acid labilie Boc group.
Chemical Properties
White to off-white powder
Synthesis
Fmoc-Tyr(Me)-OH, also known as Fmoc-Tyr(OMe)-OH, was obtained from Fmoc-Tyr(OMe)-OMe within 1h and was isolated following protocol 1 or 2 in 96% yield[1]. Under argon atmosphere, anhydrous THF (2.0 mL) was added to the protected amino acid Fmoc-Tyr(OMe)-OMe (0.12 mmol) and to MgI2 * (1.2 mmol). The suspension was heated in a sealed reactor using microwave irradiation at 120°C. A Na2S2O3 aqueous solution (0.1 M) was then added and the resulting homogeneous mixture was directly analysed by analytical HPLC and LC/MS. To isolate the product, two protocols could be applied:
Protocol 1: The crude material was purified by preparative HPLC.
Protocol 2: The crude material was extracted with AcOEt (x3). The organic layer was washed with brine, dried over MgSO4, filtered and concentrated under reduced pressure. The residue was diluted in H2O/EtOH and lyophilized.
References
[1] Berthet M, et al. MgI2 -Mediated Chemoselective Cleavage of Protecting Groups: An Alternative to Conventional Deprotection Methodologies. Chemistry - A European Journal, 2015; 21: 11014-11016.
Fmoc-Tyr(Me)-OH Preparation Products And Raw materials
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View Lastest Price from Fmoc-Tyr(Me)-OH manufacturers
- Product
- Fmoc-L-Tyr(me) 77128-72-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T
- Release date
- 2024-04-10
- Product
- FMOC-TYR(ME)-OH 77128-72-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20kg
- Release date
- 2018-08-15