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Fmoc-Tyr(Me)-OH

Product Name
Fmoc-Tyr(Me)-OH
CAS No.
77128-72-4
Chemical Name
Fmoc-Tyr(Me)-OH
Synonyms
Fmoc;FMOC-L-TYR(ME);FMOC-TYR(ME)-OH;FMOC-TYR(AL)-OH;FMOC-L-TYR(ME)-OH;Fmoc-4-Methoxy-Phe;FMOC-PHE(4-OME)-OH;FMOC-L-4-METHOXYPHE;Fmoc-L-4-MeO-Phe-OH;Methoxy phenylalanine
CBNumber
CB1468274
Molecular Formula
C25H23NO5
Formula Weight
417.45
MOL File
77128-72-4.mol
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Fmoc-Tyr(Me)-OH Property

Melting point:
161 °C
Boiling point:
647.8±55.0 °C(Predicted)
Density 
1.274±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
pka
2.97±0.10(Predicted)
form 
powder to crystal
color 
White to Almost white
InChIKey
JYQODLWFOPCSCS-QHCPKHFHSA-N
SMILES
C(O)(=O)[C@H](CC1=CC=C(OC)C=C1)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O
CAS DataBase Reference
77128-72-4(CAS DataBase Reference)
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Safety

WGK Germany 
WGK 2 water endangering
HazardClass 
IRRITANT
HS Code 
29242990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.52056
Product name
Fmoc-Tyr(Me)-OH
Purity
Novabiochem?
Packaging
5G
Price
$121
Updated
2024/03/01
Sigma-Aldrich
Product number
CDS006940
Product name
Fmoc-Tyr(Me)-OH
Purity
AldrichCPR
Packaging
10MG
Price
$68.1
Updated
2023/06/20
Sigma-Aldrich
Product number
8.52056
Product name
Fmoc-Tyr(Me)-OH
Purity
Novabiochem?
Packaging
1g
Price
$35.3
Updated
2023/01/07
Alfa Aesar
Product number
H52117
Product name
N-Fmoc-4-methoxy-L-phenylalanine, 95%
Packaging
1g
Price
$57.65
Updated
2024/03/01
Alfa Aesar
Product number
H52117
Product name
N-Fmoc-4-methoxy-L-phenylalanine, 95%
Packaging
5g
Price
$246.65
Updated
2024/03/01
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Fmoc-Tyr(Me)-OH Chemical Properties,Usage,Production

Description

Fmoc-Tyr(Me)-OH, also known as Fmoc-O-methyl-L-tyrosine, is an Fmoc protected tyrosine derivative that is potentially useful for proteomics studies and solid phase peptide synthesis techniques. Tyrosine is a important amino acid - one of the few amino acids which is phosphorylated to vary the physical properties of the peptides, and is a precursor for the formation of iodinated thyroid hormones. The Fmoc group is typically removed with a base such as pyridine - an orthogonal de-protection strategy to the acid labilie Boc group.

Chemical Properties

White to off-white powder

Synthesis

Fmoc-Tyr(Me)-OH, also known as Fmoc-Tyr(OMe)-OH, was obtained from Fmoc-Tyr(OMe)-OMe within 1h and was isolated following protocol 1 or 2 in 96% yield[1]. Under argon atmosphere, anhydrous THF (2.0 mL) was added to the protected amino acid  Fmoc-Tyr(OMe)-OMe (0.12 mmol) and to MgI2 * (1.2 mmol). The suspension was heated in a sealed reactor using microwave irradiation at 120°C. A Na2S2O3 aqueous solution (0.1 M) was then added and the resulting homogeneous mixture was directly analysed by analytical HPLC and LC/MS. To isolate the product, two protocols could be applied:
Protocol 1: The crude material was purified by preparative HPLC.
Protocol 2: The crude material was extracted with AcOEt (x3). The organic layer was washed with brine, dried over MgSO4, filtered and concentrated under reduced pressure. The residue was diluted in H2O/EtOH and lyophilized.

References

[1] Berthet M, et al. MgI2 -Mediated Chemoselective Cleavage of Protecting Groups: An Alternative to Conventional Deprotection Methodologies. Chemistry - A European Journal, 2015; 21: 11014-11016.

Fmoc-Tyr(Me)-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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Fmoc-Tyr(Me)-OH Suppliers

China 129 Europe 1 Germany 5 India 5 Japan 3 Switzerland 3 United Kingdom 2 United States 32 Global 180
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28398
Advantage
80
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View Lastest Price from Fmoc-Tyr(Me)-OH manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Fmoc-L-Tyr(me) 77128-72-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T
Release date
2024-04-10
Career Henan Chemical Co
Product
FMOC-TYR(ME)-OH 77128-72-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20kg
Release date
2018-08-15

77128-72-4, Fmoc-Tyr(Me)-OHRelated Search:

FMOC-TYR(BZL)-OH 98%,FMOC-TYR(BZL)-OH N-Fmoc-O-Phenyl-L-Tyrosine Fmoc-Tyr(Ac)-OH FMOC-L-4-Fluorophe Fmoc-L-4-Iodophenylalanine (S)-N-FMOC-4-Chlorophenylalanine FMOC-L-9-ANTHRYLALANINE FMOC-D, L-PHE(4-C(O)NH2) FMOC-L-4-Methylphe Fmoc-4-nitro-L-phenylalanine (S)-N-Fmoc-Allylglycine FMOC-L-4-CYANOPHENYLALANINE FMOC-TYR(ET)-OH FMOC-TYR(ALL)-OH,FMOC-TYR(AL)-OH FMOC-TYR(2-BR-Z)-OH FMOC-TYR(MALONYL-DI-OTBU)-OH Fmoc-Tyr(tBu)-OH Fmoc-Tyr(Me)-OH

  • Fmoc-4-Methoxy-L-Phe-OH
  • Methoxy phenylalanine
  • N-FMoc-4-Methoxy-L-phenylalanine, 95%
  • FMoc-Tyr(Me)-OH FMoc-O-Methyl-L-tyrosine
  • FMOC-(S)-b-(p-Methoxyphenyl)alanine
  • (S)-2-((((9H-Fluoren-9-yl)Methoxy)carbonyl)aMino)-3-(4-Methoxyphenyl)propanoic acid
  • N-Fmoc-O-methyl-L-tyrosine, >=99%
  • Fmoc-4-Methoxy-Phe
  • N-ALPHA-FMOC-O-METHYL-L-TYROSINE
  • N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-O-METHYL-L-TYROSINE
  • N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-O-METHYL-L-TYROSINE
  • N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-methyl-L-tyrosine
  • Fmoc-O-methyl-L-tyrosine≥ 99% (HPLC)
  • Fmoc-Tyr(Me)-OH Novabiochem
  • N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-O-METHY-L-TYROSINE
  • N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-4-METHOXY-L-PHENYLALANINE
  • (S)-2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-3-(4-METHOXY-PHENYL)-PROPIONIC ACID
  • FMOC-4-METHOXY-PHE-OH
  • FMOC-4-METHOXY-L-PHENYLALANINE
  • FMOC-4-METHOXYPHENYLALANINE
  • FMOC-L-4-METHOXYPHE
  • FMOC-TYR(ME)-OH
  • FMOC-L-TYR(ME)
  • FMOC-L-TYR(ME)-OH
  • FMOC-L-TYROSINE(METHYL ETHER)
  • FMOC-P-METHOXY-PHE-OH
  • FMOC-PHE(4-OME)-OH
  • FMOC-O-METHYL-L-TYROSINE
  • FMOC-4-METHOXYPHENYLALANINE MIN 99%
  • Fmoc-L-4-MeO-Phe-OH
  • FMOC-TYR(AL)-OH
  • (9H-Fluoren-9-yl)MethOxy]Carbonyl Tyr(Me)-OH
  • (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(4-methoxyphenyl)propanoic acid
  • Fmoc-Tyr(Me)-OH(Fmoc-4-Methoxy-Phe)
  • N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-methyl-L-tyrosine&gt
  • Fmoc-Tyr(Me)-OH (N-Fmoc-O-methyl-L-tyrosine)
  • L-Tyrosine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-methyl-
  • N-Fmoc-4-methoxy-L-phenylalanine,95%
  • N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-methoxy-L-phenylalanine
  • N-Fmoc-O-methyl-L-tyrosine
  • FMOC-TYR(ME)-OH USP/EP/BP
  • Fmoc
  • 77128-72-4
  • Phenylalanine [Phe, F]
  • Unusual Amino Acids
  • Amino Acids
  • Fmoc-Amino acid series