DMG-PEG 2000

ChemicalBook > CAS DataBase List > DMG-PEG 2000

Product Name: DMG-PEG 2000
CAS No.: 160743-62-4
Chemical Name: DMG-PEG 2000
Synonyms: DMG-PEG;mPEG-DMG;DMG-PEG 2000;DMG-mPEG2000;DMG-PEG PEG5000;DMG-PEG PEG 2000;DMG-PEG PEG10000;DMG-PEG PEG40000;DMG-PEG PEG30000;DMG-PEG PEG200000
CBNumber: CB14740239
Formula Weight: 0
MOL File: Mol file

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DMG-PEG 2000 Property

storage temp.: -20°C, sealed storage, away from moisture and light
solubility: DMSO: 100 mg/mL
form: A crystalline solid
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-25496
Product name: DMG-PEG2000
Purity: 99%
Packaging: 1g
Price: $280
Updated: 2021/12/16

BroadPharm

Product number: BP-25496
Product name: DMG-PEG2000
Purity: 99%
Packaging: 2g
Price: $490
Updated: 2021/12/16

DC Chemicals

Product number: DC40169
Product name: DMG-PEG2000
Purity: >98%
Packaging: 1g
Price: $950
Updated: 2021/12/16

DC Chemicals

Product number: DC40169
Product name: DMG-PEG2000
Purity: >98%
Packaging: 2g
Price: $1600
Updated: 2021/12/16

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DMG-PEG 2000 Chemical Properties,Usage,Production

Description

DMG-PEG 2000, also called 1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000, is used for liposome preparation. DMG-PEG 2000 has become known for lipid nanoparticle (LNP) preparation for siRNA (small interfering RNA) delivery in the COVID-19 vaccine development. DMG-PEG 2000 has been used in studies for anticancer drug delivery studies for hepatocellular, gastrointestinal, neuroendocrine and adrenocortical carcinoma.

Uses

DMG-PEG2000 is used for the preparation of liposomes for siRNA delivery, which can improve the transfection efficiency. It can also be used for the preparation of lipid nanoparticles for in vivo delivery of orally administered plasmid DNA. DMG-PEG2000 can improve the mucus permeability and delivery efficiency of nanoparticles.

Chemical Properties

DMG-PEG 2000 is soluble in ethanol, DMSO and chloroform:methanol (9:1) at a concentration of 5 mg/mL; store at -20°C. Generally transported on dry ice.

Application

DMG-PEG 2000 is a lipid excipient that has been used in combination with other lipids to form lipid nanoparticles (LNPs) for delivery of COVID-19 mRNA vaccines.

in vitro

NP-3 (0.05-1.6 mg/mL; 24 hours) does not decrease the cytotoxicity of cells in 293T, HepG2, A549, and HeLa cell lines, but the DPPC and DMG-PEG coated nanoparticles reduce cell cytotoxicity. In addition, the transfection efficiency of DPPC/DMG-PEG/(lPEI/DNA) nanoparticles (NP-3) in 293 cells is improved, and the maximum transfection efficiency (～76% eGFP positive cells) is observed.

in vivo

NP-3 (oral administration; 150 μg DNA per mouse; single dose) at 12, 24, and 36 h postadministration, luciferin substrate is intraperitoneally injected to verify its permeability. NP-3 group maintains high luciferase expression in the liver, lung, and intestine areas 12-24 h post-treatment.Additionally, NP-3 exhibits 1.5 times higher signal intensity than that of NP-1 or NP-2 group from 12 to 24 h postoral administration.

DMG-PEG 2000 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from DMG-PEG 2000 manufacturers

XIAMEN SINOPEG BIOTECH CO., LTD.

Product: Methoxypoly(ethylene glycol) dimyristoyl glycerol 160743-62-4
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 98%
Supply Ability: 1
Release date: 2021-06-22

XIAMEN SINOPEG BIOTECH CO., LTD.

Product: DMG-PEG2000（mPEG-DMG） 160743-62-4
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 1g/bottle , 10g/bottle, 100g/bottle
Release date: 2024-07-26

160743-62-4, DMG-PEG 2000Related Search:

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DMG-PEG 2000

1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000

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1,2-Dimyristoyl-sn-glycero-3-methoxypolyethylene glycol 2000

mPEG-DMG

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DMG-PEG PEG 2000

DMG-PEG

1,2-dimyristoyl-rac-glycerol-3-methoxypolyethylene glycol-2000

MPEG-2000 glyceryl 1,2-dimyristate

DMG-PEG PEG10000

DMG-PEG PEG5000

DMG-PEG PEG40000

DMG-PEG PEG30000

DMG-PEG PEG200000

DMG-PEG2000(mPEG-DMG)

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160743-62-4

DMG