DMG-PEG 2000
- Product Name
- DMG-PEG 2000
- CAS No.
- 160743-62-4
- Chemical Name
- DMG-PEG 2000
- Synonyms
- DMG-PEG;mPEG-DMG;DMG-PEG 2000;DMG-mPEG2000;DMG-PEG PEG5000;DMG-PEG PEG 2000;DMG-PEG PEG10000;DMG-PEG PEG40000;DMG-PEG PEG30000;DMG-PEG PEG200000
- CBNumber
- CB14740239
- Formula Weight
- 0
- MOL File
- Mol file
DMG-PEG 2000 Property
- storage temp.
- -20°C, sealed storage, away from moisture and light
- solubility
- DMSO: 100 mg/mL
- form
- A crystalline solid
- color
- White to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- BP-25496
- Product name
- DMG-PEG2000
- Purity
- 99%
- Packaging
- 1g
- Price
- $280
- Updated
- 2021/12/16
- Product number
- BP-25496
- Product name
- DMG-PEG2000
- Purity
- 99%
- Packaging
- 2g
- Price
- $490
- Updated
- 2021/12/16
- Product number
- DC40169
- Product name
- DMG-PEG2000
- Purity
- >98%
- Packaging
- 1g
- Price
- $950
- Updated
- 2021/12/16
- Product number
- DC40169
- Product name
- DMG-PEG2000
- Purity
- >98%
- Packaging
- 2g
- Price
- $1600
- Updated
- 2021/12/16
DMG-PEG 2000 Chemical Properties,Usage,Production
Description
DMG-PEG 2000, also called 1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000, is used for liposome preparation. DMG-PEG 2000 has become known for lipid nanoparticle (LNP) preparation for siRNA (small interfering RNA) delivery in the COVID-19 vaccine development. DMG-PEG 2000 has been used in studies for anticancer drug delivery studies for hepatocellular, gastrointestinal, neuroendocrine and adrenocortical carcinoma.
Uses
DMG-PEG2000 is used for the preparation of liposomes for siRNA delivery, which can improve the transfection efficiency. It can also be used for the preparation of lipid nanoparticles for in vivo delivery of orally administered plasmid DNA. DMG-PEG2000 can improve the mucus permeability and delivery efficiency of nanoparticles.
Chemical Properties
DMG-PEG 2000 is soluble in ethanol, DMSO and chloroform:methanol (9:1) at a concentration of 5 mg/mL; store at -20°C. Generally transported on dry ice.
Application
DMG-PEG 2000 is a lipid excipient that has been used in combination with other lipids to form lipid nanoparticles (LNPs) for delivery of COVID-19 mRNA vaccines.
in vitro
NP-3 (0.05-1.6 mg/mL; 24 hours) does not decrease the cytotoxicity of cells in 293T, HepG2, A549, and HeLa cell lines, but the DPPC and DMG-PEG coated nanoparticles reduce cell cytotoxicity. In addition, the transfection efficiency of DPPC/DMG-PEG/(lPEI/DNA) nanoparticles (NP-3) in 293 cells is improved, and the maximum transfection efficiency (~76% eGFP positive cells) is observed.
in vivo
NP-3 (oral administration; 150 μg DNA per mouse; single dose) at 12, 24, and 36 h postadministration, luciferin substrate is intraperitoneally injected to verify its permeability. NP-3 group maintains high luciferase expression in the liver, lung, and intestine areas 12-24 h post-treatment.Additionally, NP-3 exhibits 1.5 times higher signal intensity than that of NP-1 or NP-2 group from 12 to 24 h postoral administration.
DMG-PEG 2000 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from DMG-PEG 2000 manufacturers
- Product
- Methoxypoly(ethylene glycol) dimyristoyl glycerol 160743-62-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 1
- Release date
- 2021-06-22
- Product
- DMG-PEG2000(mPEG-DMG) 160743-62-4
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 1g/bottle , 10g/bottle, 100g/bottle
- Release date
- 2024-07-26