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Sodium thiomethoxide

Product Name
Sodium thiomethoxide
CAS No.
5188-07-8
Chemical Name
Sodium thiomethoxide
Synonyms
SODIUM METHANETHIOLATE;SODIUM METHYL MERCAPTIDE;METHYL MERCAPTAN SODIUM SALT;Sodium thiomethylate;Sodium methylthiolate;SODIUM METHYLMERCAPTAN;SODIUM THIOMETHOXIDE, 21 VOL. % SOLN IN WATER, A PRODUCT OF ELF ATOCHEM (SMM);Sodium me;thioformate;methanethiolate
CBNumber
CB1476576
Molecular Formula
CH3NaS
Formula Weight
70.09
MOL File
5188-07-8.mol
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Sodium thiomethoxide Property

Density 
1.12[at 20℃]
vapor pressure 
29hPa at 25℃
Flash point:
27°C
storage temp. 
Air and moisture sensitive. Store under inert gas. Sensitive to carbon dioxide Exposure to moisture.
solubility 
soluble in Water
form 
Powder
color 
White to off-white
Water Solubility 
soluble
Merck 
14,5956
BRN 
3592983
InChI
InChI=1S/CH4S.Na/c1-2;/h2H,1H3;/q;+1/p-1
InChIKey
RMBAVIFYHOYIFM-UHFFFAOYSA-M
SMILES
CS[Na]
LogP
-2.33 at 20℃
CAS DataBase Reference
5188-07-8(CAS DataBase Reference)
EPA Substance Registry System
Methanethiol, sodium salt (5188-07-8)
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Safety

Hazard Codes 
C,F
Risk Statements 
31-34-20/21/22-11-35-25-10
Safety Statements 
26-36/37/39-45-16
RIDADR 
UN 3263 8/PG 3
WGK Germany 
3
F 
1-34-10-13
HazardClass 
4.3
PackingGroup 
II
HS Code 
29309090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H226Flammable liquid and vapour

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
281018
Product name
Sodium thiomethoxide
Purity
95%
Packaging
1g
Price
$46.8
Updated
2024/03/01
Sigma-Aldrich
Product number
281018
Product name
Sodium thiomethoxide
Purity
95%
Packaging
5g
Price
$125
Updated
2024/03/01
TCI Chemical
Product number
M0096
Product name
Methyl Mercaptan Sodium Salt (ca. 15% in Water)
Packaging
25g
Price
$38
Updated
2024/03/01
TCI Chemical
Product number
M0096
Product name
Methyl Mercaptan Sodium Salt (ca. 15% in Water)
Packaging
500g
Price
$144
Updated
2024/03/01
Sigma-Aldrich
Product number
71742
Product name
Sodium methanethiolate
Purity
technical, ≥90% (RT)
Packaging
5g
Price
$122
Updated
2024/03/01
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Sodium thiomethoxide Chemical Properties,Usage,Production

Description

Sodium methanethiolate or sodium thiomethoxide (CH3SNa, MeSNa) is the sodium conjugate base of methanethiol. This compound is commercially available as a white solid. Sodium Methanethiolate is used as a nucleophile in organic synthesis. This compound is also being used as a reagent to synthesize thiol-based suberoylanilide hydroxamic acid (SAHA) analogues, compounds that act as potent histone deacetylase inhibitors. It reacts with trifluoroacetic acid and water to produce the active form of sodium trifluoroacetate. The reaction mechanism is likely due to the formation of a bicyclic heterocycle that has been shown to be effective against a number of bacteria.

Chemical Properties

Very faint yellowish red clear liquid

Uses

Used to prepare a C-21 thioether of methyl 16-prednisolonecarboxylate by mesylate displacement.

Uses

Sodium thiomethoxide is a strong nucleophile used for the synthesis of methyl aryl sulfides from halo-arenes. Alkanethiolates are efficient reagents for SN2 dealkylation of esters and aryl ethers.

Reactivity Profile

Sodium thiomethoxide is a powerful nucleophile that can be used to prepare methylthioether and other organic compounds like ethyl bromide. Its hydrolysis in moist air produces methanethiol, which has a low odor threshold and a noxious fecal smell.

Purification Methods

Dissolve the salt (10g) in EtOH (10mL) and add Et2O (100mL). Cool and collect the precipitate, wash it with Et2O and dry it in a vacuum. It is a white powder which is very soluble in EtOH and H2O. [Billmann & Jensen Bull Soc Chim Fr 3 2318 1936, Beilstein 1 III 1212.]

Sodium thiomethoxide Preparation Products And Raw materials

Raw materials

Carbon disulfide Methanol Sodium hydroxide

Preparation Products

2-Aminoethylmethylsulfone hydrochloride Simetryne Prometryn 2-(METHYLTHIO)ETHANOL 2-(Methylthio)pyrazine 4,6-DICHLORO-2-(TRIFLUOROMETHYL)QUINOLINE 2-(METHYLTHIO)THIOPHENE Ametryn Methylthio acetaldoxime 5-(METHYLSULFONYL)THIOPHENE-2-CARBOXYLIC ACID ETHYL METHANESULFONYLACETATE 4-Methylthio-2-butanone Dimethyl sulfide METHYL MERCAPTAN Prairie Net Wettable Powder ALDICARB-OXIME 2-Methyl-3-(methylthio)pyrazine 5-(METHYLTHIO)THIOPHENE-2-CARBOXYLIC ACID ALDICARB 6-(METHYLTHIO)PYRIDINE-3-CARBOXYLIC ACID Methylthioethane
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Sodium thiomethoxide Suppliers

Americas 1 Australia 1 Belgium 1 Canada 1 China 293 Europe 1 Germany 2 India 12 Japan 1 Slovakia 1 Switzerland 1 United Kingdom 4 United States 18 Global 337
Toronto Research Chemicals
Tel
--
Fax
--
Email
info@trc-canada.com
Country
Canada
ProdList
6038
Advantage
71
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View Lastest Price from Sodium thiomethoxide manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
Sodium thiomethoxide 5188-07-8
Price
US $10.00/kg
Min. Order
1kg
Purity
99.5%
Supply Ability
100
Release date
2024-11-06
Hebei Mojin Biotechnology Co., Ltd
Product
Sodium thiomethoxide 5188-07-8
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-22
Henan Aochuang Chemical Co.,Ltd.
Product
Sodium thiomethoxide 5188-07-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-17

5188-07-8, Sodium thiomethoxideRelated Search:

SODIUM TETRATHIONATE DIHYDRATE Sodium tetraborate decahydrate Sodium triacetoxyborohydride Sodium sulfide Sodium thiocyanate Sodium sulfate Sodium sulfite Sodium thiosulfate Sulfamic acid monosodium salt Sodium trimetaphosphate Sodium xylenesulfonate Sodium tetrafluoroborate Sodium tungstate Sodium stearate Sodium tert-pentoxide Sodium tripolyphosphate Sodium taurocholate Sodium thiosulfate pentahydrate Methyl Mercaptan Sodium Salt Sodium Methyl Mercaptide

  • Sodium thiomethoxide solution
  • METHANETHIOL SODIUM SALT
  • METHYL MERCAPTAN SODIUM SALT
  • SODIUM METHANETHIOLATE
  • SODIUM METHYL MERCAPTIDE
  • SODIUM METHYL SULFIDE
  • SODIUM THIOMETHOXIDE
  • Sodium thiomethoxyde
  • SODIUM THIOMETHOXIDE, 21 VOL. % SOLN IN WATER, A PRODUCT OF ELF ATOCHEM (SMM)
  • 1-Methanethiolsodiumsalt
  • Sodium methanethiol
  • Sodium methylthiolate
  • Sodium thiomethylate
  • Sodium thiomethoxide, pure, 95%
  • Sodium thiomethoxide, Methanethiol sodium salt
  • SODIUM METHYLMERCAPTAN
  • METHYL MERCAPTAN SODIUM SALT: 15% IN WATER
  • Methyl Mercaptan Sodium Salt (ca. 15% in Water)
  • Methanethiol sodium salt, Sodium methanethiolate, Sodium thiomethoxide
  • Sodium thiomethoxide, 95%, pure
  • Sodiothiomethane
  • Sodium Methanethiolate Solution
  • Sodium methanethiolate, 21% aq. soln.
  • Sodium methanethiolate ,95%
  • thioformate
  • Methanethiol, sodiuMsalt (1:1)
  • SodiuM Methanethiolate technical, >=90% (RT)
  • SodiuM thioMethoxide 95%
  • SodiuM thioMethoxide solution 21% in H2O
  • SodiuM thioMethoxide, 20% in water
  • Sodium Methanethiolate (~20% in Water)
  • sodiuM Methylsulfanide
  • SodiuM Methanethiolate, 15 wt.% solution in H2O
  • Sodium methanethiolate, 21% aqueous solution
  • Sodium me
  • Sodium methionine
  • Sodium thiomethoxide, 15% in water
  • methanethiolate
  • High purity Sodium thiomethoxide
  • 5188-07-8
  • 5188-7-8
  • 1201108
  • 1201-10-8
  • CH3NaS
  • CH3SNa
  • Building Blocks
  • Na (Sodium) Compounds (excluding simple sodium salts)
  • Typical Metal Compounds
  • Classes of Metal Compounds
  • Sulfur Compounds
  • Thiol/Mercaptan Salts
  • Organic Building Blocks
  • Classes of Metal Compounds
  • Na (Sodium) Compounds (excluding simple sodium salts)
  • Typical Metal Compounds
  • API
  • Aliphatics
  • Sulfur & Selenium Compounds