Sodium thiomethoxide
- Product Name
- Sodium thiomethoxide
- CAS No.
- 5188-07-8
- Chemical Name
- Sodium thiomethoxide
- Synonyms
- SODIUM METHANETHIOLATE;SODIUM METHYL MERCAPTIDE;METHYL MERCAPTAN SODIUM SALT;Sodium thiomethylate;Sodium methylthiolate;SODIUM METHYLMERCAPTAN;SODIUM THIOMETHOXIDE, 21 VOL. % SOLN IN WATER, A PRODUCT OF ELF ATOCHEM (SMM);Sodium me;thioformate;methanethiolate
- CBNumber
- CB1476576
- Molecular Formula
- CH3NaS
- Formula Weight
- 70.09
- MOL File
- 5188-07-8.mol
Sodium thiomethoxide Property
- Density
- 1.12[at 20℃]
- vapor pressure
- 29hPa at 25℃
- Flash point:
- 27°C
- storage temp.
- Air and moisture sensitive. Store under inert gas. Sensitive to carbon dioxide Exposure to moisture.
- solubility
- soluble in Water
- form
- Powder
- color
- White to off-white
- Water Solubility
- soluble
- Merck
- 14,5956
- BRN
- 3592983
- InChI
- InChI=1S/CH4S.Na/c1-2;/h2H,1H3;/q;+1/p-1
- InChIKey
- RMBAVIFYHOYIFM-UHFFFAOYSA-M
- SMILES
- CS[Na]
- LogP
- -2.33 at 20℃
- CAS DataBase Reference
- 5188-07-8(CAS DataBase Reference)
- EPA Substance Registry System
- Methanethiol, sodium salt (5188-07-8)
Safety
- Hazard Codes
- C,F
- Risk Statements
- 31-34-20/21/22-11-35-25-10
- Safety Statements
- 26-36/37/39-45-16
- RIDADR
- UN 3263 8/PG 3
- WGK Germany
- 3
- F
- 1-34-10-13
- HazardClass
- 4.3
- PackingGroup
- II
- HS Code
- 29309090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H226Flammable liquid and vapour
H302Harmful if swallowed
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
N-Bromosuccinimide Price
- Product number
- 281018
- Product name
- Sodium thiomethoxide
- Purity
- 95%
- Packaging
- 1g
- Price
- $46.8
- Updated
- 2024/03/01
- Product number
- 281018
- Product name
- Sodium thiomethoxide
- Purity
- 95%
- Packaging
- 5g
- Price
- $125
- Updated
- 2024/03/01
- Product number
- M0096
- Product name
- Methyl Mercaptan Sodium Salt (ca. 15% in Water)
- Packaging
- 25g
- Price
- $38
- Updated
- 2024/03/01
- Product number
- M0096
- Product name
- Methyl Mercaptan Sodium Salt (ca. 15% in Water)
- Packaging
- 500g
- Price
- $144
- Updated
- 2024/03/01
- Product number
- 71742
- Product name
- Sodium methanethiolate
- Purity
- technical, ≥90% (RT)
- Packaging
- 5g
- Price
- $122
- Updated
- 2024/03/01
Sodium thiomethoxide Chemical Properties,Usage,Production
Description
Sodium methanethiolate or sodium thiomethoxide (CH3SNa, MeSNa) is the sodium conjugate base of methanethiol. This compound is commercially available as a white solid. Sodium Methanethiolate is used as a nucleophile in organic synthesis. This compound is also being used as a reagent to synthesize thiol-based suberoylanilide hydroxamic acid (SAHA) analogues, compounds that act as potent histone deacetylase inhibitors. It reacts with trifluoroacetic acid and water to produce the active form of sodium trifluoroacetate. The reaction mechanism is likely due to the formation of a bicyclic heterocycle that has been shown to be effective against a number of bacteria.
Chemical Properties
Very faint yellowish red clear liquid
Uses
Used to prepare a C-21 thioether of methyl 16-prednisolonecarboxylate by mesylate displacement.
Uses
Sodium thiomethoxide is a strong nucleophile used for the synthesis of methyl aryl sulfides from halo-arenes. Alkanethiolates are efficient reagents for SN2 dealkylation of esters and aryl ethers.
Reactivity Profile
Sodium thiomethoxide is a powerful nucleophile that can be used to prepare methylthioether and other organic compounds like ethyl bromide. Its hydrolysis in moist air produces methanethiol, which has a low odor threshold and a noxious fecal smell.
Purification Methods
Dissolve the salt (10g) in EtOH (10mL) and add Et2O (100mL). Cool and collect the precipitate, wash it with Et2O and dry it in a vacuum. It is a white powder which is very soluble in EtOH and H2O. [Billmann & Jensen Bull Soc Chim Fr 3 2318 1936, Beilstein 1 III 1212.]
Sodium thiomethoxide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Sodium thiomethoxide manufacturers
- Product
- Sodium thiomethoxide 5188-07-8
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99.5%
- Supply Ability
- 100
- Release date
- 2024-11-06
- Product
- Sodium thiomethoxide 5188-07-8
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-09-22
- Product
- Sodium thiomethoxide 5188-07-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-17