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Robenidine hydrochloride

Product Name
Robenidine hydrochloride
CAS No.
25875-50-7
Chemical Name
Robenidine hydrochloride
Synonyms
ROBENIDINE HCL;Robenz;Nugatex;cycostat;Toraxine;khimroside;khimcoccid;Rasexinium;CYCOSTAT66G;chimcoccide
CBNumber
CB1491966
Molecular Formula
C15H14Cl3N5
Formula Weight
370.66
MOL File
25875-50-7.mol
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Robenidine hydrochloride Property

Melting point:
252-254°C
storage temp. 
0-6°C
solubility 
Robenidine hydrochloride possesses a weak solubility in water (<1 mg/L), but is soluble in organic solvents: 94 mg/L in dimethylsulfoxide, 46 mg/L in dimethylformamide, 20 mg/L in pyridine and 6.3 mg/L in ethanol (95%). The Log Kow is 3.3 (EFSA, 2004a).
form 
Solid
color 
White to off-white
CAS DataBase Reference
25875-50-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
2
RTECS 
ME8651000
Toxicity
mouse,LD50,oral,390mg/kg (390mg/kg),Journal of Agricultural and Food Chemistry. Vol. 23, Pg. 724, 1975.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
33979
Product name
Robenidine hydrochloride
Purity
VETRANAL?,analyticalstandard
Packaging
100mg
Price
$119
Updated
2024/03/01
TRC
Product number
R639000
Product name
Robenidine hydrochloride
Packaging
100mg
Price
$80
Updated
2021/12/16
Biosynth Carbosynth
Product number
IB57827
Product name
1,3-Bis[(p-chlorobenzylidene)amino]guanidine hydrochloride
Packaging
5G
Price
$50
Updated
2021/12/16
ApexBio Technology
Product number
C6934
Product name
Robenidine hydrochloride
Packaging
100mg
Price
$50
Updated
2021/12/16
ChemScene
Product number
CS-8206
Product name
Robenidine hydrochloride
Purity
≥98.0%
Packaging
100mg
Price
$60
Updated
2021/12/16
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Robenidine hydrochloride Chemical Properties,Usage,Production

Description

Robenidine hydrochloride (Dexium, Nugatex, Rasexinium, Toraxine) is an antibiotic used as an effective anticoccidial. It does not affect the earliest stages in the coccidial life-cycle and its main activity is against the almost mature first generation schizont. It is used as an aid in the prevention of coccidiosis caused by Eimeria mivati, E. brunetti, E. tenella, E. acervulina, E. maxima and E. necatrix in broiler chickens.

Chemical Properties

white or slightly yellow crystalline powder, odorless, slightly bitter taste. Very slightly soluble in ether and water, easily soluble in dilute acid or dilute alkali solution, the color gradually darkens when exposed to light.

Uses

Robenidine hydrochloride is used as a coccidiostat for use in chickens for fattening and turkeys at a minimum-maximum concentration of 30-36 mg/kg complete feed, and in rabbits for fattening at a minimummaximum concentration of 50-66 mg/kg complete feed withdrawal period of 5 days for all target animals.

Preparation

thiosemicarbazide was formed by addition and rearrangement of sodium thiocyanate with water and hydrazine. Then methylation with dimethyl sulfate and hydrazinolysis to give N.N'-diaminoguanidine sulfate. Then replaced with calcium chloride to N.N'-diaminoguanidine hydrochloride. Finally, it was condensed with p-chlorobenzaldehyde in ethanol again to produce Robenidine hydrochloride with 94% yield.

Antimicrobial activity

Robenidine hydrochloride activity against Eimeria species results from a dual action exerted upon different stages of the parasite as it develops in the intestinal mucosa (Ryley and Wilson, 1971). Initially it acts as a coccidiostat and arrests the development of the first schizont generation. Secondly, robenidine hydrochloride is coccidiocidal, killing the second generation of schizonts and possibly the merozoites. An additional effect against the sexual stage of coccidia development has been observed as well. Robenidine hydrochloride has been shown to be an inhibitor of oxidative phosphorylation (Wong et al., 1972) and is reported to affect the protein metabolism and some other metabolic process of coccidia (Lee and Millard, 1972).

Biological Activity

Robenidine Hydrochloride is an anticoccidial agent mainly for poultry which is also active against MRSA and VRE with MIC50s of 8.1 and 4.7 μM, respectively. IC50 & Target: MIC50: 8.1 μM (MRSA), 4.7 μM (VRE).
In Vitro: Robenidine (compound 1) inhibits the growth of MRSA and VRE with MIC values of 8.1 and 4.7 μM, respectively. Robenidine is bactericidal against all of the S. aureus strains tested with MBC/MIC90 ratios ≤2. A profound and negative impact on the MIC values with a 4-fold decrease with Robenidine at 2% serum and no activity at 50% serum is observed.
In Vivo: The time that the mean plasma concentration exceeds the concentration of 1 μg/mL is approximately 6 h in the Florfenicol (FFC) alone group; however, it is lowered to 4 h by Robenidine (ROB) pretreatment. The terminal elimination half-life (t1/2z), area under the concentration-time curve (AUC), area under the first moment curve (AUMC), and mean residence time (MRT) significantly decreased, whereas the elimination rate constant (λz) and total body clearance (CLz) obviously increased in rabbits pretreated with Robenidine.

Robenidine hydrochloride Preparation Products And Raw materials

Raw materials

thiosemicarbazide Acetylacetone 4-Chlorobenzaldehyde Sodium thiocyanate Bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide hydrochloride Benzaldehyde Metaclazepam Sulfaguanidine Diaminoguanidine sulfate

Preparation Products

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Robenidine hydrochloride Suppliers

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Target molecule Corp.
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View Lastest Price from Robenidine hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Robenidine hydrochloride 25875-50-7
Price
US $0.00/KG
Min. Order
1KG
Purity
99%,USP
Supply Ability
500kg/month
Release date
2021-07-23
Hebei Zhuanglai Chemical Trading Co Ltd
Product
Robenidine hydrochloride 25875-50-7
Price
US $50.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-11-19
Hebei ZB Gamay Biological Technology Co.,Ltd
Product
Robenidine Hydrochloride 25875-50-7
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
99%
Supply Ability
1000
Release date
2024-07-17

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