Germacrone

Product Name: Germacrone
CAS No.: 6902-91-6
Chemical Name: Germacrone
Synonyms: Germacron;3,7-Cyclodecadien-1-one, 3,7-dimethyl-10-(1-methylethylidene)-, (E,E)-;3,7-Cyclodecadien-1-one, 3,7-dimethyl-10-(1-methylethylidene)-, (3E,7E)-;GERMACRONE;Germacrone-RM;GERMACRONE(RG);GerMacrol (obsol;(E,E)-GerMacrone;GERMACRONE(RG) 1mg;(E,E)-Germacra-3,7(11),9-trien-6-one
CBNumber: CB1497650
Molecular Formula: C15H22O
Formula Weight: 218.33
MOL File: 6902-91-6.mol

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Germacrone Property

Melting point:: 55-58 °C
Boiling point:: 153-157 °C(Press: 13 Torr)
Density: 0.9908 g/cm3
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form: Solid
color: White to Off-White
λmax: 309nm(MeOH)(lit.)
BRN: 2047453
Stability:: Light Sensitive
LogP: 4.760 (est)
CAS DataBase Reference: 6902-91-6
NIST Chemistry Reference: 3,7-Cyclodecadien-1-one, 3,7-dimethyl-10-(1-methylethylidene)-, (e,e)-(6902-91-6)

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Safety

Safety Statements: 23-24/25
RTECS: GU2210000
HS Code: 29142990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL89677
Product name: Germacrone
Purity: phyproof? Reference Substance
Packaging: 10MG
Price: $522
Updated: 2024/03/01

Sigma-Aldrich

Product number: 42924
Product name: Germacrone
Purity: ≥95.0% (HPLC)
Packaging: 10mg
Price: $897
Updated: 2022/05/15

TCI Chemical

Product number: G0519
Product name: Germacrone
Purity: >98.0%(GC)
Packaging: 20mg
Price: $178
Updated: 2024/03/01

TCI Chemical

Product number: G0519
Product name: Germacrone
Purity: >98.0%(GC)
Packaging: 100mg
Price: $532
Updated: 2024/03/01

Cayman Chemical

Product number: 30111
Product name: Germacrone
Packaging: 5mg
Price: $68
Updated: 2024/03/01

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Germacrone Chemical Properties,Usage,Production

Description

Germacrone is a sesquiterpene that has been found in gingeraceae plants and has diverse biological activities. It inhibits pseudorabies virus (PRV) replication in Vero cells when used at concentrations ranging from 10 to 150 μM. Germacrone (50-250 μM) enhances cytotoxicity and apoptosis induced by doxorubicin in doxorubicin-resistant MCF-7/adr cells. In vivo, germacrone (5, 10, and 20 mg/kg) reduces body weight gain, visceral fat pad weight, serum insulin and plasma glucose levels, and hepatic lipid levels in a mouse model of high-fat diet-induced obesity. It decreases brain malondialdehyde (MDA) levels and activity of superoxide dismutase (SOD) and glutathione peroxidase (GPX), as well as reduces infarct volume in a rat model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).

Uses

Germacrone is an antiviral isolate of Geranium macrorrhizum which inhibits and prevents early stage influenza virus infection. It also inhibits the proliferation of glioma cells by promoting apoptosis.

Definition

ChEBI: (E,E)-germacrone is a germacrane sesquiterpenoid that has formula C15H22O. It is a natural product found in traditional medicinal plants of the family Zingiberaceae. The compound exhibits a range of pharmacological activities including anti-inflammatory, anticancer, antiviral, anti-androgenic, antioxidant, antimicrobial, antifungal, neuroprotective and insecticidal activities. It has a role as a volatile oil component, an antiviral agent, an insecticide, an anti-inflammatory agent, an antioxidant, an antineoplastic agent, an apoptosis inducer, an autophagy inducer, an antimicrobial agent, an androgen antagonist, a neuroprotective agent, a plant metabolite, an antifungal agent, an antitussive, an antifeedant and a hepatoprotective agent. It is a germacrane sesquiterpenoid and an olefinic compound.

Synthesis Reference(s)

Tetrahedron Letters, 24, p. 3489, 1983 DOI: 10.1016/S0040-4039(00)86020-7

Hazard

A poison by ingestion

Safety Profile

A poison by ingestion. When heated to decomposition it emits acrid smoke and irritating vapors.

Germacrone Preparation Products And Raw materials

Raw materials

Preparation Products

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Germacrone Suppliers

Americas 1 China 165 Europe 1 Germany 2 India 2 Japan 1 Switzerland 1 United Kingdom 1 United States 15 Global 189

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
Advantage: 61

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18738
Advantage: 57

Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11707
Advantage: 57

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 021-51613915-820 13611835272
Fax: 021 51613951
Email: mmwang@sunwaypharm.cn
Country: China
ProdList: 9734
Advantage: 57

Aktin Chemicals, Inc.

Tel: 86-28-85159085
Fax: 86-28-85152372
Email: info@aktinchem.com
Country: China
ProdList: 297
Advantage: 62

Shenzhen Sungening Bio-Tech Co., Ltd

Tel: +86-0755-89668383
Fax: +86-0755-89594066/4038
Email: sales@sungening.com
Country: China
ProdList: 1319
Advantage: 65

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 14055
Advantage: 65

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: meilunui@163.com
Country: China
ProdList: 4727
Advantage: 58

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View Lastest Price from Germacrone manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Gallium(Iii) 6902-91-6
Price: US $0.00-0.00/G
Min. Order: 1G
Purity: 99.0%
Supply Ability: 100KG
Release date: 2024-07-16

Shanghai Standard Technology Co., Ltd.

Product: Germacrone 6902-91-6
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-10-12

Career Henan Chemical Co

Product: (3Z,7Z)-3,7-Dimethyl-10-propan-2-ylidene-cyclodeca-3,7-dien-1-one 6902-91-6
Price: US $1.00/kg
Min. Order: 1g
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-24

6902-91-6, GermacroneRelated Search:

Curzerene Curzerenone Artemether Furanodienone alpha-Cyperone beta-Eudesmol Curcumenol Curcumol Erythritol ASTRAGALOSIDE I Musk ketone FORSYTHIN (-)-Huperzine A Neferine lithospermic acid B Catalpol ZEDOARY OIL Germacrone

(E,E)-Germacra-3,7(11),9-trien-6-one

(E,E)-3,7-Dimethyl-10-(1-methylethylidene)-3,7-cyclodecadien-1-one

3,7-Cyclodecadien-1-one, 3,7-dimethyl-10-(1-methylethylidene)-, (E,E)-

3,7-Dimethyl-10-(1-methylethylidene)-3,7-cyclodecadien-1-one

Germacra-3,7(11),9-trien-6-one, (E,E)-

Germacron

trans,trans-3,7-Dimethyl-10-isopropylidene-3,7-cyclodecadien-1-one

(3E,7E)-3,7-Dimethyl-10-isopropylidene-3,7-cyclodecadien-1-one

(3E,7E)-3,7-dimethyl-10-propan-2-ylidenecyclodeca-3,7-dien-1-one

Germacrone, 98%, from Curcuma zedoaria (Christm.) Rosc

GERMACRONE(RG)

GERMACRONE

(3E,7E)-10-Isopropylidene-3,7-diMethyl-3,7-cyclodecadien-1-one

(3E,7E)-3,7-DiMethyl-10-(propan-2-ylidene)cyclodeca-3,7-dienone

GerMacrol (obsol

(E,E)-GerMacrone

(3z,7z)-3,7-dimethyl-10-propan-2-ylidene-cyclodeca-3,7-dien-1-one

3,7-Cyclodecadien-1-one, 3,7-dimethyl-10-(1-methylethylidene)-, (3E,7E)-

(3E, 7E) -3,7-dimethyl-10- (propyl-2-ylidene) cyclodecane-3,7-dien-1-one

GERMACRONE(RG) 1mg

Germacrone-RM

6902-91-6

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Inhibitors